Collagen aggregate composite medical fiber with antibacterial/antibacterial function

Abstract

The invention discloses a collagen aggregate compound medical fiber with an antibacterial / bacteriostatic function. The collagen aggregate compound medical fiber is characterized in that collagen aggregate is taken as a raw material, supercritical CO2 is taken as a medium, and epoxy sodium propyl sulfonate or anhydride is taken as a modifying agent, so that acid-soluble collagen aggregate can be obtained; carboxymethyl cellulose is taken as a raw material, and sodium periodate is taken as an oxidizing agent, so that dialdehyde carboxymethyl cellulose can be obtained; the acid-soluble collagen aggregate, the dialdehyde carboxymethyl cellulose and chitin are organically mixed, and the collagen aggregate compound medical fiber can be finally prepared by the technological processes of stirring, standing and defoaming, spinning and the like. The fiber material has good biological performance, biodegradability and biodegradability of the collagen aggregate as well as excellent antibacterial / bacteriostatic activity and anti-inflammation / wound healing promotion function of the chitin; all the performances of the collagen aggregate compound medical fiber are obviously superior to those of the collagen matrix composite fiber material prepared by taking common collagen as a raw material; the collagen aggregate compound medical fiber can be taken as a biological dressing, a hemostatic material, an absorbable suture, a medical face-lifting material, and the like.

Description

technical field [0001] The invention relates to a collagen aggregate composite medical fiber with antibacterial / antibacterial functions, belonging to the field of biomedical materials. Background technique [0002] Collagen has been proven to be a biomedical material with excellent comprehensive performance. Collagen-based composite materials prepared by organically compounding it with other natural / synthetic polymer biomedical materials have always been a hot spot and difficulty in the field of collagen research. Collagen and Its composite materials have been made into different dosage forms such as gel, solution, sponge, granule, fiber and biofilm, and are widely used in biomedical fields such as tissue engineering scaffolds, biological dressings, hemostatic materials, and medical sutures. In particular, the preparation of collagen or its composite materials into medical functional fibers by wet spinning has attracted extensive attention from researchers, and some medical ...

AI Technical Summary

Problems solved by technology

[0003] 1. Collagen itself has poor spinnability and is not easy to spin;

[0004] 2. The mechanical strength of collagen-based composite fibers is generally poor, and the biodegradation performance is too fast to meet the metabolic needs of the body. At the same time, its structural stability is also poor, and it is easily affected by the external environment

[0005] In order to make up for the above shortcomings, researchers generally immerse the composite fibers prepared by wet spinning in an acetalization bath (mainly composed of formaldehyde and glutaraldehyde) to modify them, resulting in a significant decline in the biocompatibility of the material. And has potential toxicity, which directly affects the application of materials