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A kind of pharmaceutical composition preparation containing piracetam and preparation method thereof

A technology of piracetam and its composition, which is applied in the field of pharmaceutical composition injection containing piracetam and itacidate sodium and its preparation, which can solve the problems of medical personnel's operation, secondary pollution, and errors, etc. Problems, to achieve the effect that is conducive to protection, reduce damage, and avoid the trouble of preparation

Active Publication Date: 2017-10-03
SHANDONG LUOXIN PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Since ethacrynic acid is insoluble in water, its sodium salt is required for clinical injection, and it needs to be diluted with 5% glucose injection or 50ml of normal saline before use and then slowly drip or intravenously injected. The prepared solution must be used within 24 hours After all, it brings operational troubles and the possibility of errors to medical staff, and it is easy to cause secondary pollution during operation

Method used

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  • A kind of pharmaceutical composition preparation containing piracetam and preparation method thereof
  • A kind of pharmaceutical composition preparation containing piracetam and preparation method thereof
  • A kind of pharmaceutical composition preparation containing piracetam and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] prescription:

[0036]

[0037] Preparation Process:

[0038] (1) Add glucose and citric acid into water for injection prepared with a total amount of 30%, and stir until completely dissolved.

[0039] (2) Add the prescribed amount of piracetam and sodium itacidate to it, stir until it is completely dissolved, adjust the pH value to 6.0, and add water for injection to the full amount.

[0040] (3) Add 0.01-0.05% (w / v) activated carbon, heat and stir for 20 minutes, and filter to remove carbon.

[0041] (4) Fine filter with a 0.22um microporous membrane.

[0042] (5) Fill and seal in a glass ampoule, and seal.

[0043] (6) Autoclave at 121°C for 15 minutes.

[0044] (7) Light inspection and packaging.

Embodiment 2

[0046] prescription:

[0047]

[0048] Preparation Process:

[0049] (1) Add glucose and malic acid into water for injection prepared with a total amount of 30%, and stir until completely dissolved.

[0050] (2) Add the prescribed amount of piracetam and sodium itacidate to it, stir until it is completely dissolved, adjust the pH value to 6.0, and add water for injection to the full amount.

[0051] (3) Add 0.01-0.05% (w / v) activated carbon, heat and stir for 20 minutes, and filter to remove carbon.

[0052](4) Fine filter with a 0.22um microporous membrane.

[0053] (5) Fill and seal in a glass ampoule, and seal.

[0054] (6) Autoclave at 121°C for 15 minutes.

[0055] (7) Light inspection and packaging.

Embodiment 3

[0057] prescription:

[0058]

[0059] Preparation Process:

[0060] (1) Add glucose and glycine to water for injection prepared with a total amount of 30%, and stir until completely dissolved.

[0061] (2) Add the prescribed amount of piracetam and sodium itacidate to it, stir until it is completely dissolved, adjust the pH value to 6.0, and add water for injection to the full amount.

[0062] (3) Add 0.01-0.05% (w / v) activated carbon, heat and stir for 20 minutes, and filter to remove carbon.

[0063] (4) Fine filter with a 0.22um microporous membrane.

[0064] (5) Fill and seal in a glass ampoule, and seal.

[0065] (6) Autoclave at 121°C for 15 minutes.

[0066] (7) Light inspection and packaging.

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Abstract

The invention belongs to the field of pharmaceutical preparations and relates to a pharmaceutical composition preparation containing piracetam and a preparing method thereof, in particular to a pharmaceutical composition injection containing piracetam and sodium etacrynate and a preparing method thereof. The injection contains an effective quantity of piracetam and sodium etacrynate and can coordinately act on cerebral edema to enhance resistance to cerebral edema, thus better lowering water content of cerebral tissues, raising MOD and lowering MDA.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a pharmaceutical composition preparation containing piracetam and a preparation method thereof, in particular to a pharmaceutical composition injection containing piracetam and sodium ethyrenate and a preparation method thereof. Background technique [0002] Cerebral edema refers to the pathological phenomenon that the increase of water in the brain leads to the increase of brain volume, and it is the response of brain tissue to various pathogenic factors. It can cause intracranial hypertension and damage brain tissue. Clinically, it is common in neurological diseases, such as craniocerebral trauma, intracranial infection (encephalitis, meningitis, etc.), cerebrovascular disease, intracranial space-occupying disease (such as tumor), Seizures and systemic diseases such as toxic dysentery and severe pneumonia. The pathogenesis of cerebral edema is very complicated, and there are many related...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4015A61K9/08A61P7/10A61P9/10A61K31/192
Inventor 蒋燕杰高菲菲李华靳志秀
Owner SHANDONG LUOXIN PHARMA GRP CO LTD
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