Midwifery gel preparation method

A gel and reactor technology, applied in the field of midwifery gel preparation, can solve the problems of increasing local and systemic infections, weakening the lubricating effect of lubricant compositions, and unfavorable babies

Active Publication Date: 2015-07-15
成都英诺新科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] However, the disadvantage is that, on the one hand, because the puerpera will have physiological fluids such as amniotic fluid and blood to flow out from the birth canal during childbirth, the lubricating effect of the lubricant composition will often be weakened. It is easy to clean, but has a better affinity for natural ingredients with lubricating properties, and will not weaken its lubricating effect with physiological body fluids. Therefore, the lubricating effect of the composition provided by the above technical solution is not good; and on the

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Recipe 1

[0063] Propylene glycol: 200g / L

[0064] Hydroxyethyl cellulose: 45g / L

[0065] Carbomer 940: 2g / L

[0066] Hyaluronic acid: 3g / L (molecular weight about 50w)

[0067] Purified water: make up 1L

[0068] NaOH: 10% (mass concentration) to adjust the pH to 5.5‐5.6

[0069] Acetic acid buffer salt: 1.6% acetic acid buffer solution (4.8ml 0.2mol / l acetic acid plus 45.2ml 0.2mol / l sodium acetate), pH about 5.6

[0070] Preparation Process:

[0071] Slime configuration:

[0072] A drawing slime configuration: Add 5L of 10% Nacl solution to Reactor 1. Sprinkle 300g of hyaluronic acid slowly, stir at 100rpm for 10min, turn on the vacuum, add 20L of purified water while stirring, increase the speed to 200rpm after 5min and continue stirring for 15min to defoam. Store at room temperature for later use (keep stirring at 50rpm without stopping)

[0073] B configuration of water-based thickener: Sprinkle 200g of carbomer slowly into the reaction kettle 1, stir at...

Embodiment 2

[0089] Recipe 2

[0090] Propylene glycol: 200g / L

[0091] Hydroxyethyl cellulose: 45g / L

[0092] Carbomer 980: 2g / L

[0093] Hyaluronic acid: 3g / L (molecular weight about 15w)

[0094] Purified water: make up 1L

[0095] NaOH: 10% (mass concentration) to adjust the pH to 5.5‐5.6

[0096] Acetic acid buffer salt: 1.6% acetic acid buffer solution (4.8ml 0.2mol / l acetic acid plus 45.2ml 0.2mol / l sodium acetate), pH about 5.6

[0097] Refer to Example 1 for the preparation process.

experiment example 1

[0098] Experimental Example 1 Determination of microsphere particle size

[0099] Using Malvern ZS90, software: Zetasizer Software7.02, measurement conditions: dilution solvent: water, Material RI: 1.59, solvent refractive index: 1.330, number of cycles: 3 times, viscosity (cP): 0.8872, material absorption value: 0.010, temperature (°C): 25.0, cycle duration (s): 80, sampling rate (kcaps): 149.2, measurement position (mm): 4.65, cell: glass cuvette, attenuator: 6. The measurement results are shown in Table 1 and the measurement result curves are shown in figure 1 ; figure 1 The abscissa is the particle size (exponential distribution), and the ordinate is the light intensity.

[0100] Table 1 Particle size distribution of calcium alginate microspheres

[0101]

Diameter (d.nm)

% light intensity

Standard deviation (d.nm)

Average particle size: 63.78

Peak 1:

65.99

100.0

13.83

Particle size distribution: 0.002

Peak 2...

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Abstract

The present invention discloses a new midwifery gel preparation method, which is designed by referring bionics and comprises three parts such as a drawing mucilage, a gel skeleton, and gel microspheres. According to the present invention, the drawing mucilage refers a organism lubricating liquid, adopts sodium hyaluronate as a main component, is added with carbopol so as to increase skin affinity, and is added with hydroxyethyl cellulose so as to adjust viscosity; the whole formula is similar to the formula of the lubricating liquid in the human body, and the same viscosity, the same drawing ability and the same skin affinity are provided; the network skeleton gel provides strong compressibility and strong film-forming property for the system, such that about 30 kPa pressure is generated to squeeze the gel so as to form the flowing elastic viscous film with a thickness of about 0.24 [mu]m when the fetus enters the birth canal; and the system is added with 50-100 nm sodium alginate gel microspheres, such that the original interlayer sliding friction of the gel is changed into the rolling friction so as to reduce the sliding friction, effectively reduce the static friction, such that the residence time is reduced, the injury and the pain during parturient uterine contraction are reduced, and the delivery time is shortened.

Description

technical field [0001] The invention relates to a preparation method of midwifery gel, which belongs to the field of biochemical medicine. Background technique [0002] Vaginal delivery of a baby is a complicated process. Obstetrics and gynecology studies have proved that delivery is determined by three factors: the delivery product (fetus, amnion, placenta), birth canal (composed of bone and soft tissue ducts), and labor force. Obstetrics and Gynecology Studies have shown that the force that promotes childbirth is uterine contraction and gravity, while the force that inhibits childbirth is the tension of the cervix and birth canal. [0003] The birth of a human baby is divided into three stages: the opening period, the delivery period and the postpartum period. Normal labor lasts an average of 12 hours for primiparas and 8 hours for multiparas. The reason for the shorter duration of labor on average in multiparas compared with primiparous women is that the tension of the ...

Claims

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Application Information

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IPC IPC(8): A61L31/04A61L31/00A61L31/14
CPCA61L31/00A61L31/042A61L31/048A61L31/145C08L1/284C08L5/08C08L33/02
Inventor 刘成祝国华丁多浩王楠李克江吴晓波
Owner 成都英诺新科技有限公司
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