Compound bone cement with function of reducing thermal necrosis effect

Abstract

The invention relates to low-heat type compound bone cement and a preparation method thereof. Raw materials of the bone cement include a solid-phase component and a liquid-phase component; the solid-phase component comprises an acrylic polymer and a phase-change microcapsule material (PCM). The preparation method of the bone cement comprises the following steps: uniformly stirring and mixing the solid-phase component and the liquid-phase component at a certain ratio, injecting a mixture into a mould, and performing curing to obtain the low-heat type compound bone cement. The compound bone cement is nontoxic and has injectable property, curing rate and mechanical property suitable for clinic; the highest temperature in a curing process is greatly reduced, so that a thermal necrosis effect can be reduced and the use safety of the acrylic polymer bone cement in a human body is improved.

Description

technical field [0001] The invention belongs to the field of materials, in particular to an acrylate-based composite bone cement with the effect of reducing thermal necrosis. Background technique [0002] As the aging population continues to intensify, osteoporotic fractures have become a difficult problem for researchers and clinicians to face. According to EU statistics in 2013, there are 3.5 million new osteoporotic fractures in the EU every year, and medical expenses are about 37 billion euros. In 2010, the National Bureau of Statistics of my country estimated that there were 80 million patients with osteoporosis in China, and about 8 million new osteoporotic fractures occurred each year. Osteoporotic fractures often require surgical treatment, and the current problems are: fractures are often comminuted, and local bone defects are easy to form; poor bone mass, internal fixation or low holding force of the prosthesis can easily lead to the loosening of the implant, and ...

AI Technical Summary

Problems solved by technology

[0004] However, in clinical practice, the most prominent shortcoming of PMMA is that a large amount of heat is released during the polymerization process, and its maximum temperature exceeds the range that the human body can tolerate, thus causing necrosis of its surrounding tissues.

Non-physiological thermal effects will bring about many deficiencies, and ultimately lead to treatment failure: (1) During joint replacement surgery, the surrounding bone tissue is necrotic, making it impossible for PMMA to form a stable interlocking structure with the bone structure. PMMA and bone There are micro-movements between the structures, which produce a large number of PMMA particles, and long-term accumulation will form aseptic loosening; (2) During KP surgery, cancellous osteonecrosis in the vertebral body is caused, and a ring-shaped necrosis zone appears around the PMMA. The mechanical strength of this area Poor, not only easy to cause re-collapse after fracture reduction, but also a corresponding increase in the incidence of re-fracture of the same vertebral body; (3) The catastrophic complication of KP is that PMMA enters the spinal canal and damages the nerves, and the pathogenic factors of the injury are other than In addition to mechanical extrusion, thermal burns play an important role; (4) When cement augmentation is used in fracture surgery, it will cause periosteal necrosis on the outer surface of the cortical bone, and the outer callus cannot be formed, eventually resulting in delayed union or nonunion of the fracture

Therefore, there is an urgent need to solve the problem of thermal necrosis caused by PMMA in clinical practice.

[0005] Phase change materials have the characteristics of absorbing a large amount of heat without increasing the temperature during the phase change process. As cooling energy storage materials, they have been widely used in construction and military fields, but there are no relevant reports in medical materials.

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