A composite bone cement with reduced thermal necrosis effect

Abstract

The invention relates to a low-heat type composite bone cement and a preparation method thereof. The raw material of the bone cement includes a solid phase component and a liquid phase component, and the solid phase component includes an acrylic ester polymer and a phase change microcapsule material (PCM). The preparation method of the bone cement includes stirring and mixing the solid phase component and the liquid phase component in a certain proportion, pouring it into a mold, and obtaining a low-heat type composite bone cement after curing. The composite bone cement is non-toxic, has injectability, curing rate and mechanical properties suitable for clinical use, and the maximum temperature during the curing process is greatly reduced, which can reduce thermal necrosis and increase the safety of acrylate polymer bone cement in the human body sex.

Description

technical field [0001] The invention belongs to the field of materials, in particular to an acrylate-based composite bone cement with the effect of reducing thermal necrosis. Background technique [0002] As the aging population continues to intensify, osteoporotic fractures have become a difficult problem for researchers and clinicians to face. According to EU statistics in 2013, there are 3.5 million new osteoporotic fractures in the EU every year, and medical expenses are about 37 billion euros. In 2010, the National Bureau of Statistics of my country estimated that there were 80 million patients with osteoporosis in China, and about 8 million new osteoporotic fractures occurred each year. Osteoporotic fractures often require surgical treatment, and the current problems are: fractures are often comminuted, and local bone defects are easy to form; poor bone mass, internal fixation or low holding force of the prosthesis can easily lead to the loosening of the implant, and ...

AI Technical Summary

Problems solved by technology

[0004] However, in clinical practice, the most prominent shortcoming of PMMA is that a large amount of heat is released during the polymerization process, and its maximum temperature exceeds the range that the human body can tolerate, thus causing necrosis of its surrounding tissues.

Non-physiological thermal effects will bring about many deficiencies, and ultimately lead to treatment failure: (1) During joint replacement surgery, the surrounding bone tissue is necrotic, making it impossible for PMMA to form a stable interlocking structure with the bone structure. PMMA and bone There are micro-movements between the structures, which produce a large number of PMMA particles, and long-term accumulation will form aseptic loosening; (2) During KP surgery, cancellous osteonecrosis in the vertebral body is caused, and a ring-shaped necrosis zone appears around the PMMA. The mechanical strength of this area Poor, not only easy to cause re-collapse after fracture reduction, but also a corresponding increase in the incidence of re-fracture of the same vertebral body; (3) The catastrophic complication of KP is that PMMA enters the spinal canal and damages the nerves, and the pathogenic factors of the injury are other than In addition to mechanical extrusion, thermal burns play an important role; (4) When cement augmentation is used in fracture surgery, it will cause periosteal necrosis on the outer surface of the cortical bone, and the outer callus cannot be formed, eventually resulting in delayed union or nonunion of the fracture

Therefore, there is an urgent need to solve the problem of thermal necrosis caused by PMMA in clinical practice.

[0005] Phase change materials have the characteristics of absorbing a large amount of heat without increasing the temperature during the phase change process. As cooling energy storage materials, they have been widely used in construction and military fields, but there are no relevant reports in medical materials.

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