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Bioartificial blood vessels capable of self-remodeling in vivo

A bioartificial and vascular technology, applied in the field of bioartificial blood vessels, can solve the problems of lack, hypoxia and nutrition, and unfavorable remodeling of bioartificial blood vessels, and achieve the effect of extensive sources, simple production, and optimized gradual remodeling of blood vessels

Active Publication Date: 2018-05-22
广州宏畅生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the local microenvironment of tissue engineered blood vessels is a microenvironment of severe hypoxia and nutrient deficiency before the outer capillaries grow in, which is not conducive to the remodeling of bioartificial blood vessels.
How to optimize the local microenvironment and realize the remodeling of bioartificial blood vessels is a difficult problem in current research, and there is no bioartificial blood vessel that can achieve self-remodeling in vivo

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025]Example 1. Preparation of a Klotho protein-modified bioartificial blood vessel capable of regulating phosphorus metabolism and converting it into adenosine in vivo to achieve remodeling. The vascular matrix material was prepared according to the above-mentioned step 1, and after surface modification was carried out according to step 2, animal experiments were carried out.

[0026] The obtained bioartificial blood vessels were transplanted into animals. After 14 days of light and electron microscopy inspection, it can be seen that the endothelial cells in the vascular lumen are normal in shape, densely arranged, and distributed along the long axis of the blood vessels, indicating that under the above conditions, the blood vessels have successfully formed autologous endothelialization. , liquid chromatographic detection bioartificial blood vessels can release adenosine molecules continuously. One month later, HE staining, immunofluorescence staining, and electron microscope...

Embodiment 2

[0027] Example 2. Preparation of a GDNF-modified bioartificial blood vessel capable of enhancing autophagy-induced adenosine release in vivo. The vascular matrix material was prepared according to the above-mentioned step 1, and the surface modification was carried out according to step 2, followed by animal experiments.

[0028] The obtained bioartificial blood vessels were transplanted into animals. After 14 days of light and electron microscopy inspection, it can be seen that the endothelial cells in the vascular lumen are normal in shape, densely arranged, and distributed along the long axis of the blood vessels, indicating that under the above conditions, the blood vessels have successfully formed autologous endothelialization. , liquid chromatographic detection bioartificial blood vessels can release adenosine molecules continuously. One month later, HE staining, immunofluorescence staining, and electron microscope examination showed that the vascular endothelialization w...

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Abstract

The invention relates to a biological artificial blood vessel able to realize in vivo self-reconstruction. The artificial blood vessel is prepared by the method of: 1. weaving a natural biological material or artificial synthetic material into a blood vessel scaffold by electrospinning or 3D printing, or using antigen removed decellularized homologous and heterologous blood vessel; and 2. representing Klotho protein or GDNF on the blood vessel scaffold. The biological artificial blood vessel obtained in the invention has excellent mechanical performance, anticoagulation performance and biodegradability. The biological artificial blood vessel can be constructed into artificial biological blood vessels with arbitrary caliber, induces circulating endothelial progenitor cell homing in vivo, at the same time converts the blood vessel to a bioreactor sustainedly releasing adenosine, optimizes local microenvironment, achieves artificial blood vessel self-reconstruction, and ultimately forms a completely self-replaced mature blood vessel.

Description

technical field [0001] The invention relates to bioengineering technology, in particular to a bioartificial blood vessel capable of self-remodeling in vivo. Background technique [0002] At present, most of the artificial blood vessels used clinically are non-degradable polymer materials such as polyester products and polytetrafluoroethylene (PTFE). For the replacement of large blood vessels, these artificial blood vessels meet the clinical needs to a certain extent. However, for the replacement of small blood vessels with a diameter of less than 6 mm, the artificial blood vessels of this material can achieve a better patency effect in the early stage by coating the inner surface with anticoagulant or antithrombotic drugs, but the drugs are gradually released in the later stage of transplantation. After the end, it is easy to form a thrombus and eventually lead to the failure of the graft of the blood vessel. As the age of onset of coronary heart disease and diabetes advan...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/26A61L27/24A61L27/50A61L27/52A61L27/54
Inventor 朱楚洪陈文曾文
Owner 广州宏畅生物科技有限公司
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