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High-capacity boron affinity separation material and preparation method and application thereof

A separation material, high capacity technology, applied in separation methods, chemical instruments and methods, preparation of samples for testing, etc. Unsatisfactory and other problems, to achieve good application prospects, improved sensitivity and accuracy, and high recovery rates

Inactive Publication Date: 2015-08-19
NORTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the surface binding sites of the adsorbent obtained in this way are limited, and the adsorption capacity is mostly unsatisfactory, which cannot meet the requirements of high-throughput processing samples, and the amount of adsorbent is relatively large, which may lead to low recovery.

Method used

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  • High-capacity boron affinity separation material and preparation method and application thereof
  • High-capacity boron affinity separation material and preparation method and application thereof
  • High-capacity boron affinity separation material and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1: Preparation of high-capacity boron affinity material based on silica gel

[0027] (1) Weigh 5.0 g of activated silica gel, then disperse it in 100 mL of redistilled toluene, 2.0 mL of 82.5 mM 4-chloromethylphenyltrimethoxysilane (4-CPTS), and react at 110°C After 12 h, the product was washed with toluene, methanol, and acetone for 3-4 times in sequence, and dried in vacuum at 50°C to obtain silica gel (silica-Cl for short) with surface-bonded initiator;

[0028] (2) Weigh 1.0 g of the above silica-Cl, ultrasonically disperse it in N,N-dimethylformamide, add 1.6 g of 3-acrylamidophenylboronic acid and 0.20 g of 2, 2'-bipyridine; the mixture is frozen repeatedly - Vacuum-thawing cycle, quickly add 0.10 g cuprous bromide under nitrogen protection; keep stirring, react at 90 °C for 8-16 hours, then wash with methanol and water in sequence. In order to thoroughly clean the residual catalyst, the obtained silica particles were dispersed in 60 mL methanol / 0.25 M ED...

Embodiment 2

[0033] Example 2: Preparation of high-capacity boron affinity separation material based on silica gel-coated magnetic nanoparticles

[0034] (1) Weigh 2.0 g of ferroferric oxide magnetic nanoparticles coated with silica gel by hydrolysis of ethyl orthosilicate, and then disperse them in 100 mL of double-distilled toluene, 2.0 mL of 120.2 mM 4-chloromethylbenzene Trimethoxysilane (4-CPTS) was reacted at 110°C for 12 h. After the reaction, the product was washed with toluene, methanol and acetone for 3-4 times, and dried in vacuum at 50°C to obtain magnetic nanoparticles with surface-bonded initiators. ;

[0035] (2) Weigh 1.0 g of the above-mentioned magnetic particles, ultrasonically disperse them in N,N-dimethylformamide, add 1.6 g of 3-acrylamidophenylboronic acid and 0.20 g of 2, 2'-bipyridyl; the mixture is repeatedly frozen- Vacuum-thawing cycle, quickly add 0.10 g cuprous bromide under nitrogen protection; keep stirring, react at 90 °C for a certain period of time, then...

Embodiment 3

[0038] Example 3: Adsorption of catechol by a high-capacity boron affinity separation material based on silica gel

[0039] Weigh a series of 20 mg of the silica gel-based high-capacity boron affinity material prepared in Example 1, add 5 mL of catechol solutions of different concentrations, ultrasonically disperse, and shake at 25°C with a constant temperature oscillator (150 r / min) Shake for 10 min to reach adsorption equilibrium, centrifuge, collect the supernatant, and carry out chromatographic analysis. The maximum adsorption capacity of the boron affinity material for catechol was 513.6 μmol / g.

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PUM

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Abstract

The invention discloses a high-capacity boron affinity separation material. According to the material, surface-initiated atom transfer radical polymerization and terminal modification technologies are combined, alkene compounds containing phenylboronic acid serve as monomers to be polymerized on solid matrix surfaces, and phenylboronic acid containing alkynyl is used for polymer chain end functionalization through click chemistry, and accordingly, the separation materials containing high-density phenylboronic acid groups are obtained. The separation material is high in absorption capacity and specificity and has the advantages of being few in use material and high in recovery rate and sensitivity when being used for separating and gathering cis dihydroxylation substances. (img file= 'dest_path_image001. TIF' wi= '468' he= '224' / ).

Description

technical field [0001] The invention relates to a high-capacity boron affinity separation material modified by a phenylboronic acid functionalized polymer and a preparation method thereof, belonging to the technical field of novel separation material synthesis. Background technique [0002] Boronic acid can form reversible, pH-regulated cyclic esters with cis-ortho-hydroxyl. Based on such a high specificity, boron affinity materials have been widely used for the selective separation and enrichment of substances containing cis-ortho-dihydroxyl. Set, such as nucleosides, sugars, glycoproteins and catecholamines and other substances. It can be seen that substances containing cis-ortho-dihydroxyl are mostly related to the research of hot fields in life sciences such as proteomics, metabolomics, and glycomics. The development of boron affinity materials is of great significance to the field of life sciences . [0003] At present, boron affinity materials mainly select suitable ...

Claims

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Application Information

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IPC IPC(8): B01J20/286B01J20/30B01D15/38G01N1/34G01N1/40
Inventor 王薇卫引茂
Owner NORTHWEST UNIV
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