Amphotericin B nano composite, and preparation method thereof

Abstract

The invention relates to an amphotericin B nano composite containing amphotericin B, cholesteryl sodium sulfate, and cholesterol-PEG. According to the amphotericin B nano composite, cholesterol-PEG is used for modifying a nano composite containing amphotericin B and cholesteryl sodium sulfate, so that particle size and encapsulation efficiency are desirable, and excellent long circulation properties are achieved.

Description

technical field

[0001] The invention relates to an amphotericin B nanocomposite and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background technique

[0002] Amphotericin B (AMB) is a polyene antifungal drug isolated from the culture fluid of Streptomyces. Its antifungal mechanism is to combine with sterols (mainly ergosterol) on the fungal cell membrane, change the membrane permeability, and the cell contents flow out, thereby causing fungal cell death. It is clinically used to treat serious visceral or systemic infections caused by deep fungi.

[0003] Amphotericin B is insoluble in water. In order to improve its solubility, sodium deoxycholate was first used to solubilize it. The trade name of the marketed product is Fungizone®. However, Fungizone® has strong nephrotoxicity, and almost all patients may experience varying degrees of renal dysfunction, proteinuria, casturia, elevated blood urea nitrogen and creatinine, de...

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