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Method for preparing Glechoma hedracea volatile oil microcapsule and application thereof

A technology of volatile oil and scutellaria, which is applied in the field of preparation of microcapsules of volatile oil of stalks, can solve the problems such as no public literature reports, and achieve the effect of simple and feasible technical route, good reactivity, and avoiding oxidation and volatilization

Inactive Publication Date: 2015-09-16
NANJING ZELANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Through literature search, do not see the public literature report identical with the present invention

Method used

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  • Method for preparing Glechoma hedracea volatile oil microcapsule and application thereof

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Experimental program
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Effect test

Embodiment 1

[0024] Dissolve 30g of zein in water to prepare an aqueous solution of zein with a mass volume ratio of 5%, adjust the pH to 10.0 with sodium bicarbonate, and then adjust the solution to pH 8.0 with acetic acid; dissolve 50g of gelatin in water to prepare a mass volume The colloidal solution with a ratio of 6% was adjusted to pH 4.0 with acetic acid; 20g of Liscarina volatile oil was added to the zein aqueous solution, after stirring evenly, the obtained colloidal solution was added, and after stirring at a high speed of 15000r / min for 10min, the High-pressure homogenizer, homogenize three times under the conditions of temperature 80°C and pressure 50MPa to form a mixture with uniform particle size; after cooling the mixture at 0°C for 24 hours, the condensation temperature is -60°C, the pressure is 0.5KPa, and the final temperature is 20 Freeze-drying under the condition of ℃ to obtain the microcapsules of the volatile oil of Lismodium chinensis in powder form.

Embodiment 2

[0026] Dissolve 35g of zein in water to prepare an aqueous zein solution with a mass volume ratio of 8%, adjust the pH to 10.0 with sodium bicarbonate, and then adjust the solution to pH 8.0 with acetic acid; dissolve 40g of gelatin in water to prepare a mass volume The colloidal solution with a ratio of 3% was adjusted to pH 4.0 with acetic acid; 25g of Lisium saliva volatile oil was added to the zein aqueous solution, after stirring evenly, the obtained colloidal solution was added, and after stirring at a high speed of 10000r / min for 10min, the High-pressure homogenizer, homogenize three times under the conditions of temperature 70°C and pressure 30MPa to form a mixture with uniform particle size; after cooling the mixture at 0°C for 24 hours, the condensation temperature is -50°C, the pressure is 0.4KPa, and the final temperature is 15 Freeze-drying under the condition of ℃ to obtain the microcapsules of the volatile oil of Lismodium chinensis in powder form.

Embodiment 3

[0028] Dissolve 40g of zein in water to prepare an aqueous zein solution with a mass volume ratio of 6%, adjust the pH to 10.0 with sodium bicarbonate, and then adjust the solution to pH 8.0 with acetic acid; dissolve 30g of gelatin in water to prepare a mass volume The colloidal solution with a ratio of 4% was adjusted to pH 4.0 with acetic acid; 30g of Lisalis volatile oil was added to the zein aqueous solution, and after stirring evenly, the obtained colloidal solution was added, and after 10min high-speed stirring at 12000r / min, it was passed into High-pressure homogenizer, homogenize three times under the conditions of temperature 75°C and pressure 40MPa to form a mixture with uniform particle size; after cooling the mixture at 0°C for 24 hours, the condensation temperature is -55°C, the pressure is 0.2KPa, and the final temperature is 10 Freeze-drying under the condition of ℃ to obtain the microcapsules of the volatile oil of Lismodium chinensis in powder form.

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Abstract

The invention discloses a method for preparing a glechoma hedracea volatile oil microcapsule and an application thereof. Corn protein and gelatin serve as wall materials, glechoma hedracea volatile oil serves as a core material, and then a glechoma hedracea volatile oil microcapsule is prepared and obtained through high-pressure homogenization, freezing and drying. The obtained glechoma hedracea volatile oil microcapsule is in a powder shape and good in water solubility and stability, the defects that glechoma hedracea volatile oil is not dissolved in water and volatile components are likely to be lost are overcome, and original active components of the glechoma hedracea volatile oil are not prone to being damaged and are slowly released. The method for preparing the glechoma hedracea volatile oil microcapsule is simple, the yield of the microcapsule is high, entrapment efficiency and the drug-loading rate are high, remarkable anti-bacterial activity is achieved, and the method can be applied to air conditioner formulas.

Description

Technical field [0001] The present invention involves a preparation method and application of Qiancao's oil micro -capsule. Background technique [0002] Lian Qiancao is a lip -shaped promoter -shaped plant promoted blood dan dry all grass.Dry or use it fresh.Lian Qiancao is used in Jiangsu folk to diuretic stones, also known as "Jiangsu Money Cao", which treats thermal dumpling, humid and humid jaundice, swelling and pain, and falling damage.Clinically, it is mainly used for urination, treating bladder stones, renal stones, ureter, nephritis edema, cholecystitis, gallstone, mumps, burns, etc.According to bacteriostatic experiments, Liancao extract is extremely sensitive to Golden Bacizol, and is moderate sensitive to dysentery, Greenland, and typhoid bacteria.At present, the chemical research of Qiancao is limited to volatile components, and has less research on its volatile pharmacological effects. [0003] Volatal oil is a type of effective ingredient in Chinese medicine. It i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K36/53A61K47/42A61P31/04
Inventor 刘东锋杨成东
Owner NANJING ZELANG MEDICAL TECH
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