Pentacyclic triterpene compound and its preparation method, its pharmaceutical composition and purpose thereof

A compound, C1-C6 technology, applied in the direction of drug combination, steroids, organic chemistry, etc., can solve problems such as preparation difficulties
CN104910239AActive Publication Date: 2015-09-16SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
Publication Date
2015-09-16

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Abstract

The present invention relates to a pentacyclic triterpenoid compound represented by general formula (I) and preparation method thereof, pharmaceutical composition comprising the compound, uses of the compound in preparation of drugs for treating type 2 diebetes, and uses of the compound in treating type 2 diebetes.
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Description

technical field

[0001] The present invention relates to a class of TGR5 (G protein-coupled bile acid membrane receptor) agonists, in particular to a class of pentacyclic triterpenoids, a preparation method thereof, and a pharmaceutical composition comprising the compound, and Said compounds can act as TGR5 agonists. Background technique

[0002] Diabetes is caused by different etiologies (such as genetic factors, immune dysfunction, microbial infection and its toxins, free radicals, mental factors, etc.) that lead to hypofunction of pancreatic β cells and / or resistance of body cells to insulin. A characteristic metabolic disorder syndrome. According to the statistics of the International Diabetes Federation (IDF), in 2010, there were more than 43 million people with diabetes among the people aged 20-79 in China, and the prevalence rate reached 4.5%. Diabetes has become a disease that endangers human safety and health.

[0003] At present, the drugs for the treatment of di...

Claims

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