Injectable expansion type bone cement and preparation method thereof

A bone cement and expansion technology, which is applied in the field of medical biomaterial preparation, can solve the problems of water absorption and swelling, easy to fall off, weak bonding, high elastic modulus, etc., and achieve the effects of avoiding friction and wear, considerable volume expansion ratio, and good strength

Active Publication Date: 2015-09-23
XIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to provide an injectable expandable bone cement, which solves the problem that the existing PMMA bone cement causes different degrees of wear and tear on the joints in the human body due to volume shrinkage, weak combination, excessive strength, and high elastic modulus. ; At the same time, it can also solve the problem that only the surface can absorb water and expand easily when adding water-swellable components to the existing bone cement.

Method used

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  • Injectable expansion type bone cement and preparation method thereof
  • Injectable expansion type bone cement and preparation method thereof

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preparation example Construction

[0034] The present invention also provides a preparation method for the above-mentioned injectable expansive bone cement, comprising the following steps:

[0035] Step 1, preparation of solid phase components

[0036] Methyl methacrylate (MMA) and acrylic acid (AA) are used as reactive monomers, and under the action of an initiator and a crosslinking agent, a polymerization reaction occurs to form a methyl methacrylate-acrylic acid copolymer.

[0037] Step 2, Preparation of Liquid Phase Components

[0038] Mix methyl methacrylate, N,N-dimethyl-p-toluidine and hydroquinone evenly, to liquid phase components.

[0039] Step 3, Preparation of Injectable Expandable Bone Cement

[0040] Mix the solid phase components prepared in step 1 with the liquid phase components prepared in step 2 at a mass ratio of 1.5:1 to 3:1, and stir uniformly for 1 min to 3 min to obtain bone cement fluid. Quickly inject into a syringe and self-cure for 10 minutes to 30 minutes in an environment with ...

Embodiment 1

[0050] A kind of injectable expansible bone cement, its preparation method comprises the following steps:

[0051] Step 1, preparation of solid phase components

[0052] Methyl methacrylate-acrylic acid copolymer was prepared by dispersion polymerization. The MMA and AA monomers were distilled under reduced pressure before use respectively to remove the polymerization inhibitor therein. Dissolve 0.2g of dispersant PVP in 50ml of water, put it into a three-necked flask equipped with a condenser, a mechanical stirrer and a nitrogen conduit, raise the temperature to 60°C, blow nitrogen for 0.5h, slowly add the dissolved initiator potassium persulfate, crosslinking MMA and AA monomers of N-N methylene bisacrylamide, wherein, 0.04 g of initiator potassium persulfate, 0.07 g of cross-linking agent N-N methylene bis acrylamide, 18 g of monomer MMA, and 1.44 g of AA. A constant temperature reaction was carried out at 60° C. for 6 hours to obtain an emulsion sample. Centrifuge the e...

Embodiment 2

[0058] A kind of injectable expansible bone cement, its preparation method comprises the following steps:

[0059] Step 1, preparation of solid phase components

[0060] Methyl methacrylate-acrylic acid copolymer was prepared by dispersion polymerization. The MMA and AA monomers were distilled under reduced pressure before use respectively to remove the polymerization inhibitor therein. Dissolve 0.18g of dispersant PVP in 60ml of water, put it into a three-necked flask equipped with a condenser, a mechanical stirrer and a nitrogen conduit, raise the temperature to 60°C, blow nitrogen for 0.5h, slowly add the dissolved initiator potassium persulfate, cross-linking Agent N-N methylenebisacrylamide MMA, AA monomer. Among them, the initiator potassium persulfate is 0.03g, the crosslinking agent N-N methylenebisacrylamide is 0.056g, the monomer MMA is 16g, and the AA is 2.88g. A constant temperature reaction was carried out at 80° C. for 12 hours to obtain an emulsion sample. C...

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Abstract

The invention discloses injectable expansion type bone cement. The injectable expansion type bone cement is made by mixing a solid phase composition and a liquid phase composition according to the mass ratio of 1.5:1-3:1, wherein the solid phase composition is a methyl methacrylate-acrylic acid copolymer while the liquid phase composition is a mixture of methyl methacrylate, N,N-dimethyl toluidine and hydroquinone. The preparation method includes: taking the methyl methacrylate and the crylic acid as reactive monomers generating polymerization reaction under the action of an initiator and a cross-linking agent to generate the methyl methacrylate-acrylic acid copolymer; evenly mixing the methyl methacrylate, the N,N-dimethyl toluidine and the hydroquinone to the liquid phase composition; mixing the solid phase composition with the liquid phase composition according to the mass ratio of 1.5:1-3:1 in proportion, stirring to obtain bone cement fluid, and obtaining the injectable expansion type bone cement after self-setting.

Description

technical field [0001] The invention belongs to the technical field of medical biomaterial preparation, relates to an injectable expansive bone cement, and also relates to a preparation method of the injectable expansive bone cement. Background technique [0002] Bone cement is a medical material used in orthopedic surgery, mainly used in artificial joint replacement surgery. Because of its physical properties and its appearance and properties after solidification, it is quite similar to white cement for building decoration, so it has such a name. Bone cement has been widely used in clinical orthopedics since 1958 when bone cement was first applied to fix the femoral prosthesis for successful total hip arthroplasty. Bone cement is currently widely used in the fields of spinal repair molding and facial cosmetic repair, and has important medical value. [0003] Bone cement mainly includes polymethyl methacrylate bone cement (PMMA), calcium phosphate bone cement (CPC) and magn...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/48A61L27/50
Inventor 汤玉斐陈磊赵康吴子祥谭权昌
Owner XIAN UNIV OF TECH
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