Intestinal disease treatment pharmaceutical composition and preparation method thereof

A technology of composition and prescription, which is applied in the field of pharmaceutical composition for treating intestinal diseases and its preparation, can solve problems such as incomplete disintegration of polycarbophil calcium, and achieve improved disintegration performance, good disintegration effect, and void space uniform effect

Active Publication Date: 2015-11-04
SUZHOU CHUNGHWA CHEM & PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to solve the problem of incomplete disintegration of polycarbophil calcium in the prior art, and provide a polycarbophil calcium composition and a preparation method thereof

Method used

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  • Intestinal disease treatment pharmaceutical composition and preparation method thereof
  • Intestinal disease treatment pharmaceutical composition and preparation method thereof
  • Intestinal disease treatment pharmaceutical composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] The formulation of polycarbophil calcium composition:

[0047] calcium polycarbophil

100g

Croscarmellose Sodium

16g

[0048] microcrystalline cellulose

33g

Magnesium stearate

1g

Propylene Glycol

6g

[0049] The preparation method of polycarbophil calcium composition tablet is:

[0050] The croscarmellose sodium and polycarbophil calcium of 50% recipe quantity are mixed at room temperature by equal volume increasing method; the preparation mass concentration is 10% propylene glycol aqueous solution, standby, and 10% propylene glycol aqueous solution is added to the above-mentioned mixture Medium granulation, drying and sizing at 60°C, then adding the remaining amount of croscarmellose sodium, prescription amount of microcrystalline cellulose, and magnesium stearate to it, and finally compressing into tablets to obtain tablets .

Embodiment 2

[0052] The prescription is the same as in Example 1, and the preparation method is: the croscarmellose sodium and polycarbophil calcium of 50% recipe quantity are mixed at room temperature by an equal increase method; the preparation mass concentration is 10% propylene glycol aqueous solution, Standby, add 10% propylene glycol aqueous solution to the above mixture to granulate, dry and granulate at 60°C, then add the remaining amount of croscarmellose sodium and the prescribed amount of microcrystalline cellulose, hard Magnesium steatate, filled capsules, to obtain calcium polycarbophil capsules.

Embodiment 3

[0054] The prescription is the same as in Example 1, and the preparation method is: the croscarmellose sodium and polycarbophil calcium of 50% recipe quantity are mixed at room temperature by an equal increase method; the preparation mass concentration is 10% propylene glycol aqueous solution, Standby, add 10% propylene glycol aqueous solution to the above mixture to granulate, dry and granulate at 60°C, then add the remaining amount of croscarmellose sodium and the prescribed amount of microcrystalline cellulose, hard Magnesium fatty acid, finally divided into granules.

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PUM

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Abstract

The invention discloses an intestinal disease treatment pharmaceutical composition and a preparation method thereof. The intestinal disease treatment pharmaceutical composition comprises, by weight, 100 parts of calcium polycarbophil, 7.5-30 parts of disintegrant, 19-48 parts of stuffing, 0.5-4 parts of lubricant and 2.5-8 parts of propylene glycol. The propylene glycol added into the intestinal disease treatment pharmaceutical composition has function of improving tissue structure of the composition and making gaps among particles more uniform so as to quicken disintegration of the particles in an acid environment. As the intestinal disease treatment pharmaceutical composition is prepared by a way of adding the disintegrant in granulation and mixing the disintegrant after granulation, the intestinal disease treatment pharmaceutical composition tablet has good disintegration effect.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to a pharmaceutical composition for treating intestinal diseases and a preparation method thereof. Background technique [0002] Irritable bowel syndrome, constipation, and diarrhea are one of intestinal diseases that seriously plague people's life and health. [0003] Calcium polycarbophil (Calcium polycarbophil) is a hydrophilic polyacrylic resin, which has water absorption and has a significant binding ability to water. It can absorb water more than 60 times its own weight. Because it expands after absorbing water, it is especially suitable for Intestinal water-absorbing agent, when it is used clinically to treat diarrhea, it can be used to absorb free water in excrement, make it into jelly, and produce shaped stool. It is a new drug for treating constipation and diarrhea. Patients with sodium, such as edema, high blood pressure, and chronic constipation patients with heart ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/48A61K9/16A61K31/78A61K47/10A61P1/00A61P1/12A61P1/10
Inventor 李远福马晓华周渭铭
Owner SUZHOU CHUNGHWA CHEM & PHARMA IND
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