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Artichoke extract dispersible tablets and preparing method thereof

A technology of artichoke extract and dispersible tablets, which is applied in the field of traditional Chinese medicine tablets, can solve the problems of low dissolution rate, poor dispersibility, and difficult absorption, and achieve the effects of controlling hygroscopicity, less loss, and fast disintegration speed

Active Publication Date: 2015-11-04
XIAMEN TASMAN BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because artichoke contains more carbohydrates and has a higher viscosity, it will have disadvantages such as poor dispersibility, low dissolution rate, and difficult absorption when it is made into ordinary tablets, capsules, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] An artichoke extract dispersible tablet. Each 1000 artichoke extract dispersible tablets includes 100g of artichoke freeze-dried powder and a drug carrier. The drug carrier includes: 200g of filler, microcrystalline cellulose, 100g of lactose, and crosslinking of disintegrant 30 g of polyvinylpyrrolidone, 5 g of sodium alginate as a swelling auxiliary material, 50-250 mL of ethanol solution of 5% polyvinylpyrrolidone as a binder, 3 g of stevia as a corrective agent, and 10 g of talc as a lubricant. The preparation method is as follows:

[0027] 1) Take the artichoke flower buds into slices with a thickness of 1 cm, pre-freeze them in a refrigerator at -20°C for 24 hours, then place them in a freeze dryer at a vacuum of 40 Pa for 24 hours, make powder, and pass through a 40-50 mesh sieve. Add 5 times the amount (mass to volume ratio, the same below) of 50% ethanol, reflux extraction 2 times, 1h each time, the extracts are filtered separately, the filtrate is combined, and t...

Embodiment 2

[0031] An artichoke extract dispersible tablet. Each 1000 artichoke extract dispersible tablets includes 150g of artichoke freeze-dried powder and a drug carrier. The drug carrier includes: a filler 100g of microcrystalline cellulose, 100g of mannitol, and a disintegrant. 35 g of polyvinylpyrrolidone, 5 g of sodium alginate as a swelling adjuvant, 50-250 mL of ethanol solution of 5% polyvinylpyrrolidone as a binder, 3 g of stevia as a corrective agent, and 5 g of magnesium stearate as a lubricant. The preparation method is as follows:

[0032] 1) Take the artichoke flower buds into slices with a thickness of 1 cm, pre-freeze them in a refrigerator at -20°C for 24 hours, then place them in a freeze dryer at a vacuum of 40 Pa for 24 hours, make powder, and pass through a 40-50 mesh sieve. Add 10 times the amount of 60% ethanol, reflux and extract 2 times, each 1h, the extracts are filtered separately, the filtrates are combined, and the ethanol is recovered under reduced pressure t...

Embodiment 3

[0036] An artichoke extract dispersible tablet, each 1000 artichoke extract dispersible tablets includes 200g artichoke freeze-dried powder and a drug carrier, the drug carrier includes: filler 80g microcrystalline cellulose, lactose 60g, mannitol 60g, disintegrating Antilytic agent cross-linked polyvinylpyrrolidone 35g, swelling auxiliary material pregelatinized starch 5g, binder 6% polyvinylpyrrolidone ethanol solution 50-250mL, corrective agent acesulfame K 4g, lubricant micro powder silica gel 10g. The preparation method is as follows:

[0037] 1) Take the artichoke flower buds into slices with a thickness of 1 cm, pre-freeze them in a refrigerator at -20°C for 24 hours, then place them in a freeze dryer at a vacuum of 40 Pa for 24 hours, make powder, and pass through a 40-50 mesh sieve. Add 20 times the amount of 80% ethanol, reflux and extract 3 times, each 4h, the extracts are filtered separately, the filtrates are combined, and the ethanol is recovered under reduced press...

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PUM

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Abstract

The invention discloses artichoke extract dispersible tablets and a preparing method thereof. The preparing method includes the steps that artichoke flower buds are taken, freezed and dried, ethanol extraction is conducted, ultrafiltration membrane processing is conducted, clear paste is formed in a concentration mode, and artichoke free-dried powder is obtained through freeze-drying; the artichoke free-dried powder, filling agents, part of disintegrating agents, swelling auxiliary materials and corrigent are evenly mixed, bonding agents are added, granulation is conducted in a wet mode, drying and granulating are conducted, the disintegrating agents and lubricating agents are added and evenly mixed, tabletting is conducted, and artichoke extract dispersible tablets are obtained. The artichoke extract dispersible tablets have the advantages of being high in disintegration and dissolution speed, high in bioavailability and simple in preparing process and is especially suitable for industrial production.

Description

Technical field [0001] The invention relates to the field of traditional Chinese medicine tablets, in particular to an artichoke extract dispersible tablet and a preparation method thereof. Background technique [0002] Artichoke, also known as chrysanthemum thistle, cardoon, French lily, and lotus lily, is scientifically named Cynara scolymus L., and is Artichoke in Italian. It is a perennial herb belonging to the genus of Compositae and is native to the Mediterranean coast. The main edible parts are the torus without buds and the plump bracts, which are rich in polyphenols (chlorogenic acid, cynic acid, caffeic acid) and flavonoids (rutin, luteolin, naringenin) The main functional chemical components such as, terpenes, etc., have significant physiological functions. They can be used as raw materials for medicines and health products, and can also be used as medicines to prevent insufficient bile secretion and protect the liver and protect the liver. In recent years, research h...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K36/28A61K47/38A61P1/16A61P39/06A61P3/06A61P1/14A61P9/12
Inventor 汤须崇邓爱华蔡婀娜
Owner XIAMEN TASMAN BIO TECH
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