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A growth factor composite dressing capable of bonding tissue fissures and its preparation method

A technology of growth factors and slits, applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, medical science, etc., can solve the problems of complex preparation process, painless patients, multiple drug components, etc., and achieve good biocompatibility , reduce pain, improve the effect of the microenvironment

Inactive Publication Date: 2017-12-29
GUANGDONG TAIBAO MEDICAL SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent CN 10302788 A reports a kind of absorbable medical dressing and its preparation method, and growth factors are added in its drug components, but its preparation process is relatively complicated; Patent CN 10267 1231A reports a preparation method of a marine source composite dressing, A dressing prepared by extracting collagen from marine fish epidermis and adding growth factors and related functional components, but the dressing contains many medicinal ingredients and has certain toxic and side effects; similar patent reports on growth factors include CN 102078636 A , CN 103007339 A, CN 102397585 A and CN104288828 A, etc.
However, for operations or deep wounds with fissures, it is still necessary to rely on sutures, which brings unconsciousness and pain to patients.

Method used

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  • A growth factor composite dressing capable of bonding tissue fissures and its preparation method

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Experimental program
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Embodiment 1

[0037] A growth factor composite dressing capable of bonding tissue fissures, comprising an alginate gel layer and a non-woven fabric layer, the main components of the alginate gel layer include: sodium alginate, calcium carbonate, gluconolactone, Glycerin, sodium carboxymethylcellulose, allantoin, alpha-cyanoacrylate, cell growth factor, protective agent.

[0038] A preparation method of a growth factor composite dressing capable of bonding tissue fissures is as follows:

[0039] (1) Add 40 parts of sodium alginate, 12.5 parts of calcium carbonate, 20 parts of gluconolactone, 6 parts of glycerin, and 3 parts of sodium carboxymethylcellulose into 75 parts of deionized water and stir evenly to form a mixed solution A;

[0040] (2) Add 0.05 parts of allantoin, 4 parts of α-cyanoacrylate, 0.1 part of cell growth factor and 0.2 part of protective agent into 100 parts of deionized water and stir evenly to form a mixed solution B. The cell growth factor is epidermal growth factor, ...

Embodiment 2

[0045] A growth factor composite dressing capable of bonding tissue fissures, comprising an alginate gel layer and a non-woven fabric layer, the main components of the alginate gel layer include: sodium alginate, calcium carbonate, gluconolactone, Glycerin, sodium carboxymethylcellulose, allantoin, alpha-cyanoacrylate, cell growth factor, protective agent.

[0046] A preparation method of a growth factor composite dressing capable of bonding tissue fissures is as follows:

[0047] (1) Add 50 parts of sodium alginate, 20 parts of calcium carbonate, 30 parts of gluconolactone, 2 parts of glycerin, and 1 part of sodium carboxymethylcellulose into 50 parts of deionized water and stir evenly to form a mixed solution A;

[0048] (2) Add 0.2 part of allantoin, 1 part of α-cyanoacrylate, 0.08 part of cell growth factor and 0.1 part of protective agent into 70 parts of deionized water and stir evenly to form a mixed solution B. The cell growth factor is Epidermal growth factor and fib...

Embodiment 3

[0053] A growth factor composite dressing capable of bonding tissue fissures, comprising an alginate gel layer and a non-woven fabric layer, the main components of the alginate gel layer include: sodium alginate, calcium carbonate, gluconolactone, Glycerin, sodium carboxymethylcellulose, allantoin, alpha-cyanoacrylate, cell growth factor, protective agent.

[0054] A preparation method of a growth factor composite dressing capable of bonding tissue fissures is as follows:

[0055] (1) Add 30 parts of sodium alginate, 5 parts of calcium carbonate, 10 parts of gluconolactone, 10 parts of glycerin, and 5 parts of sodium carboxymethylcellulose into 100 parts of deionized water and stir evenly to form a mixed solution A;

[0056] (2) Add 0.1 part of allantoin, 5 parts of α-cyanoacrylate, 0.05 part of cell growth factor and 0.05 part of protective agent into 50 parts of deionized water and stir evenly to form a mixed solution B. The cell growth factor is Epidermal growth factor and...

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Abstract

The invention discloses a growth factor composite dressing capable of bonding tissue fissures and a preparation method thereof. The growth factor composite dressing capable of bonding tissue fissures includes an alginate gel layer and a non-woven fabric layer , the alginate gel layer includes: sodium alginate, calcium carbonate, gluconolactone, glycerin, sodium carboxymethylcellulose, allantoin, α-cyanoacrylate, cell growth factor, protective agent. The dressing can replace sutures to a certain extent, and fundamentally effectively promote wound healing, save patients with deep wounds from the pain of surgical sutures, and effectively reduce the generation of scars.

Description

technical field [0001] The invention belongs to the field of medical dressings, in particular to a growth factor composite dressing capable of bonding tissue fissures and a preparation method thereof. Background technique [0002] After the skin has been damaged or cut, the normal healing response leads to the formation of scars. The healing process of damaged skin consists of three phases—an inflammatory phase, a granulation phase, and a remodeling phase of the matrix. In the phase of inflammatory response, a series of biochemical reactions such as changes in vascular dynamics, increased vascular permeability, and swelling at the injured site appear. Local tissue degeneration, exudation, and proliferation are used to eliminate and repel foreign lethal cells, laying the foundation for the mission. During the granulation stage, fibroblasts secrete a large amount of collagen, elastin and fibronectin, etc., and form a large number of collagen fibers, but collagenase continues ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/18A61L15/28A61L15/18A61L15/20A61L15/44C08J3/075
Inventor 韦加娜陈锦涛熊亮何立彬
Owner GUANGDONG TAIBAO MEDICAL SCI TECH