Purification method of acetonitrile for liquid chromatography-mass spectrometer

Abstract

The invention discloses a purification method of acetonitrile for a liquid chromatography-mass spectrometer. The method is characterized in that impurities in a raw material acetonitrile are removed through processes such as modified activated carbon adsorption and the like so as to obtain acetonitrile for a liquid chromatography-mass spectrometer. By the purification method of acetonitrile for a liquid chromatography-mass spectrometer, acetonitrile with its purity being greater than or equal to 99.99 wt% can be obtained, thus meeting the high-purity requirement of a liquid chromatography-mass spectrometer. The acetonitrile obtained after purification can be applied in the field of liquid chromatography-mass spectrometers, and the application range of acetonitrile is broadened.

Description

technical field [0001] The invention relates to the field of solvent purification, in particular to a method for purifying acetonitrile for liquid chromatography-mass spectrometry. Background technique [0002] The online coupling of chromatography-mass spectrometry combines the separation ability of chromatography with the qualitative function of mass spectrometry to achieve more accurate quantitative and qualitative analysis of complex mixtures. It also simplifies the pretreatment process of the sample and makes the sample analysis easier. Chromatography-mass spectrometry includes gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry. Liquid chromatography-mass spectrometry and gas chromatography-mass spectrometry complement each other to analyze compounds of different properties. [0003] Liquid Chromatography Mass Spectrometer (LC-MS for short) is a high-end instrument in the organic analysis market. Liquid chromatography (LC) can effectively...

AI Technical Summary

Problems solved by technology

As a mobile phase solvent, the higher the purity, the better the separation effect of organic matter in the sample, and the high-purity solvent can avoid the phenomenon of insufficient ionization of the analyte caused by the existence of impurities, especially metal ions. In the mass spectrometry analysis, it complexes with the measured substance and produces interference peaks in the mass spectrometer, which leads to misjudgment of the determination of molecular weight and other parameters, and greatly reduces the accuracy of the liquid chromatography-mass spectrometry measurement results

[0004] As a solvent with excellent performance, acetonitrile can dissolve various organic, inorganic and gaseous substances, but its purification is very difficult

Because industrial acetonitrile is made from petrochemical products, the product contains many organic impurities such as heterocyclic aromatic hydrocarbons containing carbon-carbon double bonds. Their boiling range is only a few degrees different from that of acetonitrile. , such as high solubility and the ability to form an azeotropic system with many organic substances, although the impurities are very small, because there are many azeotropic systems, it is difficult to remove the above impurities even with very good rectification equipment

On the other hand, the traditional acetonitrile purification process does not have a special process for removing metal ions, so that the content of metal ion impurities in acetonitrile is relatively high

Therefore, it is difficult to achieve acetonitrile that meets the high purity requirements of liquid chromatography-mass spectrometry through existing purification techniques.

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