Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Postoperative antiemetic medicine of tropisetron hydrochloride composition

A technology of tropisetron hydrochloride and its composition, which is applied in the field of medicine, and can solve problems such as difficulties in preparing preparations, unsatisfactory hygroscopicity of impurity content crystal forms, and affecting stability, etc.

Inactive Publication Date: 2015-12-09
QINGDAO HUAZHICAO PHARMA CO LTD
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there have been many studies on the crystal form of tropisetron hydrochloride, but the impurity content, stability and hygroscopicity of the crystal form are still not ideal, which affects its own stability and also brings problems to the preparation of the preparation. here comes the difficulty

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Postoperative antiemetic medicine of tropisetron hydrochloride composition
  • Postoperative antiemetic medicine of tropisetron hydrochloride composition
  • Postoperative antiemetic medicine of tropisetron hydrochloride composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1: Preparation of Tropisetron Hydrochloride Crystals

[0020] Dissolve tropisetron hydrochloride in a mixed solvent of methanol and acetonitrile whose volume is 10 times the weight of tropisetron hydrochloride at 35°C. The volume ratio of methanol and acetonitrile is 3:1. After the dissolution is completed, add a volume of hydrochloric acid Dichloromethane solvent 6 times the weight of tropisetron, lower the temperature to room temperature within 1-2 hours, keep at room temperature for 3 hours, then further lower the temperature to 0-5°C, and then, at 0-5°C After standing for 2-3 hours, crystals are precipitated to obtain tropisetron hydrochloride crystals.

[0021] The prepared tropisetron hydrochloride crystals use Cu-Kα ray to measure the X-ray powder diffraction pattern obtained as figure 1 Shown, its purity as determined by high performance liquid chromatography is 99.9%.

Embodiment 2

[0022] Example 2: Preparation of tropisetron hydrochloride composition

[0023] The composition is: 1 part by weight of tropisetron hydrochloride crystal prepared by the present invention, and 0.01 part by weight of arginine.

[0024] The preparation method is:

[0025] (1) Weigh tropisetron hydrochloride crystals and arginine in proportion and mix them thoroughly;

[0026] (2) Dispense into sterilized vials and stopper them.

Embodiment 3

[0027] Example 3: Preparation of tropisetron hydrochloride composition

[0028] The composition is: 1 part by weight of tropisetron hydrochloride crystal prepared by the present invention, and 0.02 part by weight of arginine.

[0029] The preparation method is:

[0030] (1) Weigh tropisetron hydrochloride crystals and arginine in proportion and mix them thoroughly;

[0031] (2) Dispense into sterilized vials and stopper them.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses postoperative antiemetic medicine of a tropisetron hydrochloride composition, and belongs to the technical field of medicine. The composition consists of tropisetron hydrochloride and arginine, wherein the tropisetron hydrochloride is a crystal; an X-ray powder diffraction figure obtained through Cu-K alpha ray measurement is shown as the Figure 1. The novel crystal form of the tropisetron hydrochloride provided by the invention is different from the crystal form structure in the prior art; experimental verification pleasantly shows that the purity of the novel crystal compound is high; the liquidity is good; the stability is good; the impurity content is low; moisture cannot be absorbed; the clinical application is safe and reliable; powder injection prepared from the novel crystal form compounds has high stability; the stability is high after the composition is matched with solvents; the content of insoluble micro particles is very low; the lansoprazole composition is very suitable for clinic application.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a postoperative antiemetic drug tropisetron hydrochloride composition. Background technique [0002] Tropisetron hydrochloride is a selective peripheral neuron and central nervous system 5-hydroxytryptamine receptor antagonist, which can selectively block the vomiting reflex center, the excitation of peripheral neuron presynaptic 5-hydroxytryptamine receptors, and act on afferent The 5-hydroxytryptamine receptor active in the vagus nerve in the postrema area of ​​the central nervous system can prevent and treat nausea and vomiting caused by chemotherapy without causing extrapyramidal adverse reactions. [0003] In the prior art, there have been many studies on the crystal form of tropisetron hydrochloride, but the impurity content, stability and hygroscopicity of the crystal form are still not ideal, which affects its own stability and also brings problems to the preparation of th...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/46A61K47/18A61P1/08C07D451/12
Inventor 刘学键
Owner QINGDAO HUAZHICAO PHARMA CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com