Zinc oxide-gadolinium-drug composite nanoparticle, and preparation method and application thereof

A composite nanoparticle and zinc oxide nanotechnology, applied in the field of nanomaterials, can solve the problems of large volume, difficult to degrade and excrete, cumulative poisoning, etc.

Inactive Publication Date: 2015-12-09
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, commonly used nano-platforms such as polymer microspheres and mesoporous silica are too large to be degraded and excreted. Nano-particles containing heavy metal components such as rare earth compounds have the risk of cumulative poisoning. The development and utilization of high biological safety Nano drug loading platform has great value for practical application

Method used

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  • Zinc oxide-gadolinium-drug composite nanoparticle, and preparation method and application thereof
  • Zinc oxide-gadolinium-drug composite nanoparticle, and preparation method and application thereof
  • Zinc oxide-gadolinium-drug composite nanoparticle, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Synthesis of zinc oxide (ZnO) quantum dots

[0025] Weigh 0.47 g of zinc methacrylate powder into a three-necked flask, add 25 ml of absolute ethanol, and heat to 72° C. until it is completely dissolved. After cooling to room temperature, add 0.06 g of azoisobutyronitrile (AIBN) and 3.75 ml of polyethylene glycol monomethyl ether methacrylate (PEGMEMA), and heat to 72 ° C under the action of magnetic stirring; 10 min Afterwards, 25 ml of lithium hydroxide solution (0.14 mol / L) and 0.06 g of azoisobutyronitrile (AIBN) were added. Stir magnetically at 72°C for 1 hour. After it was cooled to room temperature, it was put into a dialysis bag and dialyzed in deionized water for 3 days to obtain polymer-modified ZnO quantum dots.

[0026] (2) Synthesis of zinc oxide-gadolinium nanoparticles

[0027] Add 2.35 ml of gadolinium chloride aqueous solution (10 mmol / l) to 10 ml of polymethacrylate-modified zinc oxide quantum dots (0.941 mg / ml) in water, stir overnight at room ...

Embodiment 2

[0031] The preparation method was the same as in Example 1, but the gadolinium chloride (10 mmol / L) used in step (2) was 2.35 ml, the stirring time was changed to 15 days, and other conditions remained unchanged. Under this condition, gadolinium (III) ions can fully coordinate with the carboxyl groups on the surface of zinc oxide, and its longitudinal relaxation rate is 55.3 per millimole per second.

Embodiment 3

[0033] The preparation method was the same as in Example 1, but the gadolinium chloride (10 mmol / L) used in step (2) was 1 ml, and other conditions remained unchanged. Under this condition, there are fewer Gd ions on the ZnO surface, and its longitudinal relaxation rate is 47.2 per millimole per second.

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Abstract

The invention belongs to the technical field of nanometer materials, and particularly relates to a zinc oxide-gadolinium-drug composite nanoparticle, and a preparation method and application thereof. The composite nanoparticle comprises a zinc oxide nanocrystal core, a polymer shell, gadolinium (III) ions modified by coordinate bonds and surface-loaded anti-cancer drug molecules, has high stability, luminescence property and magnetic relaxation rate and can be applied to cell and small animal fluorescence imaging, magnetic resonance imaging, mouse tumor treatment and the like. The preparation method includes coating a zinc oxide nanoparticle with a polymer through two copolymerization reactions, coordinating a large quantity of carboxyl groups carried by the polymer with the gadolinium (III) ions to magnetize the nanoparticle, and loading the drug molecules onto the surface of the nanoparticle. A nanoparticle drug loading platform has a good fluorescence-magnetic resonance imaging function, high drug loading rate and high release rate, is low in toxicity and is completely degraded in mouse bodies without residues, thereby having better biosecurity and medication specificity than anti-cancer drugs.

Description

technical field [0001] The invention belongs to the technical field of nanomaterials, and in particular relates to a zinc oxide-gadolinium-drug composite nanoparticle which integrates multiple functions of fluorescence imaging, magnetic resonance imaging, anticancer drug loading and release, and its preparation method and application. Background technique [0002] Cancer has become a frequently-occurring and common disease in the 21st century, seriously threatening human health and life. Although the commonly used chemotherapy methods for cancer can inhibit the deterioration of cancer to a certain extent, they will inevitably damage normal cells and healthy tissues during the treatment process, and will eventually destroy the patient's immune system. The combination of nanotechnology and biomedicine has produced nano-drug carriers, which can efficiently load anti-cancer drugs, and use the microenvironment of the tissue around the tumor or the micro-environment inside the can...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/06A61K49/00A61K47/48A61K9/14A61K31/704A61K31/4545A61K31/496A61P35/00
Inventor 熊焕明马莹莹王天伊
Owner FUDAN UNIV
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