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Absorbable lumen stent and preparing method and application thereof

An absorption tube and tube wall technology, applied in medical science, surgery, etc., can solve problems such as technical difficulties, and achieve wide application prospects, good biocompatibility, and good compression-grip resilience.

Active Publication Date: 2015-12-16
QINGDAO HUISHENG HUIZHONG BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the limitation of solubility, it has technical difficulties in practical application

Method used

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  • Absorbable lumen stent and preparing method and application thereof
  • Absorbable lumen stent and preparing method and application thereof
  • Absorbable lumen stent and preparing method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] An absorbable lumen stent is characterized by a hollow tubular structure made of acylated aminopolysaccharide as a material, and the tube wall has or does not have a permeable hole structure or pattern structure.

[0028] The acylated amino polysaccharide is a polyacylated glucosamine polysaccharide, the total acylation degree in its molecular structure is greater than or equal to 70%, and the acyl group is acetyl, propionyl, butyryl, hexanoyl, octanoyl, One or more of decanoyl, lauroyl, palmitoyl and other aliphatic or aromatic acyl groups, the molecular structure of acylated aminopolysaccharide is:

[0029]

[0030] In the formula, R 1 , R 2 or R 3 is H, acetyl (-C 2 H 3 O), propionyl (-C 3 H 5 O), butyryl (-C 4 H 7 O), hexanoyl (-C 6 H 11 O), octanoyl (-C 8 H 15 O) or one or more of decanoyl, lauroyl, palmitoyl and other aliphatic or aromatic acyl groups, the degree of acylation is greater than or equal to 70%.

Embodiment 2

[0031] Example 2 Screening of absorbable lumen stent tubing:

[0032] (1) Preparation of diaphragm:

[0033] Preparation of chitosan film: Weigh 2 g of chitosan powder (degree of deacetylation 92.5%), add 100 ml of 2% acetic acid aqueous solution (volume fraction), stir and dissolve, and prepare a weight-to-volume ratio (w / v) of 2 % chitosan glue. Measure 15ml of chitosan glue and place it in a PP square plate with a side length of 50mm×50mm, and let it dry in a fume hood. The dried film is placed in a 2% NaOH aqueous solution (weight percent concentration, the same below) for acid-base neutralization, washed with water until pH is neutral, and dried to obtain a chitosan film.

[0034] Preparation of chitin film: Weigh 2 g of chitin powder, add 100 ml of hexafluoroisopropanol solution, stir to dissolve, and prepare 2% chitin glue (w / v). Measure 15ml of chitin glue solution and place it in a stainless steel square plate with a side length of 50mm×50mm, and let it stand and d...

Embodiment 3

[0043] Example 3 Preparation of absorbable lumen stent tubing 1:

[0044] Weigh 20 g of chitosan powder (degree of deacetylation 92%), put it into a glass reaction vessel, add 50 mL of acylating reagent acetic anhydride solution, add 100 mL of methanol, control the temperature to 10°C, and add 70% perchloric acid solution under stirring 1ml was used as a catalyst, and the reaction was stirred for 36h. After the reaction is completed, filter, solid-liquid separation, put the solid into a 5% NaOH aqueous solution, neutralize acid-base, centrifuge, solid-liquid separation, elute the solid with water, dehydrate with 95% ethanol, heat and dry at 60 °C to obtain acylation Acylated aminopolysaccharide 1 with a degree of 74.5%. Acylated aminopolysaccharide 1 has an acetyl group structure with an acetyl group content of 74.5%.

[0045] Weigh 2.5g above-mentioned acylated aminopolysaccharide 1, add 61ml of hexafluoroisopropanol solution (specific gravity 1.60) as solvent, stir and dis...

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Abstract

The invention discloses an absorbable lumen stent which is characterized in that the absorbable lumen stent is of a hollow tubular structure and made of acyl amino polysaccharide, and the tube wall is provided with or not provided with a transparent hole structure or pattern structure. The lumen stent can serve as a blood vessel stent, a biliary stent or a urethral stent, is used for treating narrowing of the blood vessel, the bile duct and the urine tube cavity and can be degraded and absorbed in a human body, the situation that the lumen stent stays in the body for a long time can be avoided, and the absorbable lumen stent has wide market prospect.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to a lumen stent material, in particular to an absorbable lumen stent material and a preparation method and application thereof. Background technique [0002] Lumen stents have a wide range of clinical uses, and can be used for esophageal stents, bile duct stents, urethral stents, artificial blood vessels, and the like. The bile duct stent is used for the treatment of pancreaticobiliary duct obstruction and cholestasis caused by pancreatic cancer. Urethral stents are used to treat urethral strictures that make it difficult to urinate due to an enlarged prostate compressing the urethra. Artificial blood vessels, especially small-diameter artificial blood vessels (diameter ≤ 6 mm), are used to replace small peripheral blood vessels in patients or defects in the body to improve the blood supply of peripheral tissues of the body. Small-bore artificial blood vessels, bile duct stents ...

Claims

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Application Information

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IPC IPC(8): A61L31/04A61L31/14C08B37/08
Inventor 刘万顺
Owner QINGDAO HUISHENG HUIZHONG BIOLOGICAL TECH CO LTD
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