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Capsule for treating peptic ulcer

A peptic ulcer and capsule technology, which is applied in the field of capsules for the treatment of peptic ulcer, can solve the problems of difficult solubility and loss of active ingredients in water, achieve good analgesic effect, improve drug efficacy and activity, and have good gastric mucosa repair effect Effect

Inactive Publication Date: 2016-02-03
门源县雪草木生物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, traditional Chinese medicinal materials are mostly decocted in water, but some active ingredients are not easily soluble in water, or are lost during the decoction process. Therefore, in order to make better use of medicinal material resources, it is necessary to prepare pharmaceutical compositions method for research

Method used

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  • Capsule for treating peptic ulcer
  • Capsule for treating peptic ulcer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The preparation of embodiment 1 capsule of the present invention

[0025] (1) Preparation of drug granules

[0026] 3 parts of zushima, 0.5 part of anisodina, 9 parts of dried ginger, 10 parts of seabuckthorn; first add 10 times the amount of 80% v / v ethanol solution to reflux for extraction once, extract for 1 hour, filter, the filtrate is set aside, and the filter residue is decocted with water 2 times, add 8 times of water each time, decoct for 30 minutes each time, combine the ethanol extract and water decoction, concentrate to a thick paste with a relative density of 1.22-1.25 (60°C), add dextrin, dextrin The total dosage is 1.5 times of the dry weight of the extract, wet granulated, and dried to obtain the pharmaceutical granules of the present invention.

[0027] (2) Preparation of capsules

[0028] Get 1000g of prepared drug granules, add 30g of magnesium stearate, mix evenly, and pack into capsules to obtain capsules.

Embodiment 2

[0029] The preparation of embodiment 2 capsules of the present invention

[0030] (1) Preparation of drug granules

[0031] 1 part of zushima, 0.6 part of anisodina, 6 parts of dried ginger, 10 parts of seabuckthorn; add 10 times the amount of 70% ethanol solution to reflux and extract once, extract for 1 hour, filter, and the filtrate is set aside, and the filter residue is decocted twice with water. Add 8 times the amount of water each time, decoct for 30 minutes each time, combine the ethanol extract and water decoction, concentrate to a thick paste with a relative density of 1.22-1.25 (60°C), add dextrin, the total amount of dextrin is 3.0 times the dry weight of the extract, wet granulation, and drying to obtain the drug granules of the present invention.

[0032] (2) Preparation of capsules

[0033] Get 1000g of prepared drug granules, add 40g of magnesium stearate, mix evenly, and pack into capsules to obtain capsules.

[0034] The beneficial effects of the present i...

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Abstract

The invention discloses a capsule for treating peptic ulcer. The capsule is prepared by the following steps: evenly mixing 100 parts by weight of medicinal particle and 1 to 5 parts by weight of lubricant, and then filling the mixture into capsules; wherein the medicinal particle comprises the following components in parts by weight: 1 to 3 parts of daphne giraldii, 0.3 to 0.6 part of anisodus tanguticus, 6 to 10 parts of dry ginger, and 6 to 10 parts of sea-buckthorn. Through the specific formula mentioned above, the capsule does not have strong medicinal odor, and is capable of effectively treating gastric ulcer, duodenal ulcer and erosive gastritis. A novel drug is provided for the peptic ulcer treatment in clinic. At the same time, through the pharmacodynamic tests, people find that the pharmacodynamic activity can be improved through the alcohol-water extraction mode, and the traditional Chinese herbals are saved.

Description

technical field [0001] The invention relates to a capsule for treating peptic ulcer. Background technique [0002] Peptic ulcer mainly refers to chronic ulcers that occur in the stomach and duodenum. Among them, gastric and duodenal ulcers refer to localized circular or oval full-thickness defects of the gastric and duodenal mucosa, the muscularis mucosa is penetrated, and fibrous scars are inevitably left after healing. Covered by epithelium, the muscularis mucosa cannot regenerate. The etiology can be summed up as the self-digestion of gastric mucosa by gastric acid and pepsin or the destruction of gastric mucosal barrier due to various reasons. In recent years, it has been considered that the formation of ulcers has an important relationship with Helicobacter pylori infection in the stomach. [0003] Chronic erosive gastritis, also known as verrucous gastritis or pimple-like gastritis, generally only sees dyspepsia symptoms such as fullness after meals, pantothenic aci...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/48A61P1/04
Inventor 徐继锋卞海军许婧
Owner 门源县雪草木生物药业有限公司
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