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Detecting method for medicinal preparation for treating gynecological inflammation

A technology of pharmaceutical preparations and detection methods, which is applied in the detection field of pharmaceutical preparations for treating gynecological inflammation, can solve the problems of chromatographic peak interference, repeated operations or complex index selection, and poor pertinence.

Active Publication Date: 2016-02-03
贵州远程制药有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although the above literatures report the single detection method of Sophora flavescens and other medicinal materials and the quality standard research method of Kangfuyan Tablets and Soft Capsules, but according to the above method, first of all, there are many identification or content determination methods and types of single medicinal materials, which are targeted. Not strong, it will cause repeated operations or complex selection of indicators, and the mutual interference factors of compound preparations are not considered; In addition, when the method is verified, the resolution is not good, or the analysis time is long, and there are other phenomena such as interference of chromatographic peaks, and the content determination of the important components of Phellodendron Phellodendron is not reflected in the research on the quality standards of the preparation. , so the existing detection of pharmaceutical preparations for the treatment of gynecological inflammation can not meet the requirements

Method used

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  • Detecting method for medicinal preparation for treating gynecological inflammation
  • Detecting method for medicinal preparation for treating gynecological inflammation
  • Detecting method for medicinal preparation for treating gynecological inflammation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0184] The detection method of Kangfuyan Capsules, the steps are as follows:

[0185] Properties: This product is a hard capsule, the contents are brown granules and powder; taste bitter;

[0186] Identification: (1) Take the contents of this product and observe under a microscope: the fibers are bright yellow, often in bundles, and the surrounding cells contain square crystals of calcium oxalate, forming crystal fibers; the cell walls containing crystals are lignified and thickened; the cells of corkstone are bright yellow, round-like Shaped or spindle-shaped, 35-128 μm in diameter, some are branched, with sharp ends and thick walls; cork cells of Sophora flavescens are polygonal, with intermittent pits on the anticlinal wall, and vessels with bordered pits;

[0187] (2) Take 2g of the content of this product, add 0.3ml of concentrated ammonia test solution, add 25ml of dichloromethane, heat and reflux for 30 minutes, let cool, filter, evaporate the filtrate to dryness, add 2...

Embodiment 2

[0204] The detection method of Kangfuyan Capsules, the steps are as follows:

[0205] Properties: This product is a hard capsule, the contents are brown granules and powder; taste bitter;

[0206] Identification: (1) Take the contents of this product and observe under a microscope: the fibers are bright yellow, often in bundles, and the surrounding cells contain square crystals of calcium oxalate, forming crystal fibers; the cell walls containing crystals are lignified and thickened; the cells of corkstone are bright yellow, round-like Shaped or spindle-shaped, 35-128 μm in diameter, some are branched, with sharp ends and thick walls; cork cells of Sophora flavescens are polygonal, with intermittent pits on the anticlinal wall, and vessels with bordered pits;

[0207](2) Take 2g of the content of this product, add 0.3ml of concentrated ammonia test solution, add 25ml of dichloromethane, heat and reflux for 35 minutes, let cool, filter, evaporate the filtrate to dryness, add 2m...

Embodiment 3

[0224] The detection method of the pharmaceutical preparation for treating gynecological inflammation, the steps are as follows:

[0225] Properties: When this product is a sugar-coated tablet, the content will be brown to tan after removing the coating; the taste is bitter;

[0226] When this product is a film-coated tablet, the content will be brown to tan after removing the coating; the taste is bitter;

[0227] When this product is a soft capsule, the content is a brown liquid; the taste is bitter;

[0228] When this product is in the form of granules, it is brown granules; the taste is slightly sweet;

[0229] When this product is taken as an oral liquid, it is a brown liquid; the taste is slightly sweet;

[0230] When this product is a suppository, it is a brown suppository.

[0231] This product is vaginal effervescent tablet, which is brown to tan tablet.

[0232] Identification: (1) Take the pharmaceutical preparation of the present invention, grind the solid dosa...

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Abstract

The invention discloses a detecting method for a medicinal preparation for treating gynecological inflammation. The detecting method comprises trait identification and detection as well as content detection. Cortex phellodendri amurensis and radix sophorae flavescentis are subjected to microscopic identification, and radix sophorae flavescentis, matrine, oxymatrine, ferulic acid, cortex phellodendri amurensis and fructus forsythiae are used as references to respectively conduct thin-layer identification on radix sophorae flavescentis, Chinese angelica, cortex phellodendri amurensis and fructus forsythiae in the medicinal preparation; the content detection is used for detecting matrine and oxymatrine in radix sophorae flavescentis as well as berberine hydrochloride in cortex phellodendri amurensis according to a high performance liquid chromatography. Compared with the prior art, according to the established detecting method for the medicinal preparation for treating gynecological inflammation, the adopted method is scientific and reasonable, high in accuracy and good in reproducibility, can comprehensively and effectively control the quality of the medicinal preparation for treating gynecological inflammation, and can better ensure the clinical efficacy and the safety of the preparation.

Description

technical field [0001] The invention relates to a detection method of medicines, in particular to a detection method of pharmaceutical preparations for treating gynecological inflammation, and belongs to the technical field of medicines. Background technique [0002] Gynecological inflammation is a common disease of women, mainly refers to the inflammation of female reproductive organs, specifically including female vulvitis, vaginitis, cervicitis, and pelvic inflammatory disease. The common symptoms of gynecological inflammation are mainly vulva and vaginal itching, and some local erosions, accompanied by burning pain, dysuria, frequent urination, increased vaginal secretions, redness and swelling, etc. Inflammation is not treated in time, in addition to causing inflammation to spread and cross-infection in various physiological parts, it will also bring many complications, even lead to malignant lesions in some parts, and make the body in the environment of inflammation fo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/84G01N30/90G01N30/02
Inventor 程吉祥
Owner 贵州远程制药有限责任公司