Chtiosnaoligosaccharide (COS) capsule and preparation method thereof

A technology of chitosan oligosaccharides and capsules, applied in the field of chitosan oligosaccharides capsules and its preparation, can solve the problems of easy moisture absorption, low molecular weight, easy oxidation, etc., and achieve high solubility, high oxidation resistance, and good sealing performance Effect

Active Publication Date: 2016-03-09
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the defects of low molecular weight, easy moisture absorption and easy oxidation in the prior art, the object of the present invention is to provide a kind of chitosan capsule and preparation method thereof, to solve the above-mentioned defects

Method used

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  • Chtiosnaoligosaccharide (COS) capsule and preparation method thereof
  • Chtiosnaoligosaccharide (COS) capsule and preparation method thereof
  • Chtiosnaoligosaccharide (COS) capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1, A kind of chitosan oligosaccharide capsule

[0035] The content is 100% chitosan oligosaccharide;

[0036] The capsule shell comprises the following components and parts by weight thereof:

[0037] 8 parts of hydroxypropyl starch, 4 parts of xanthan gum, 5 parts of thickener, 4 parts of plasticizer and 16 parts of water; Described thickener is made of guar gum and propylene glycol alginate by weight ratio 1.2:3.5 Composition, described plasticizer is made up of glycerin and triethyl citrate by weight ratio 3.5:2.

[0038] Preparation:

[0039] S1 Grind the chitosan oligosaccharide into a fine powder, pass through a 20-mesh sieve to obtain a fine powder;

[0040] S2 performs wet granulation on the fine powder obtained in step S1, the temperature of the wet granulation is 25° C., the humidity is 40%, and after granulation, dry until the water content is less than 10%, to obtain the content;

[0041] S3 Grind hydroxypropyl starch into fine powder, add xa...

Embodiment 2

[0043] Embodiment 2, A kind of chitosan oligosaccharide capsule

[0044] Described content comprises following component and weight percentage thereof:

[0045] Chitooligosaccharide 92%, microcrystalline cellulose 2%, 5% povidone solution 2%, calcium stearate 1%, absolute ethanol 2% and micropowder silica gel 1%;

[0046] The capsule shell comprises the following components and parts by weight thereof:

[0047] 4 parts of hydroxypropyl starch, 2 parts of xanthan gum, 4 parts of thickener, 3 parts of plasticizer and 10 parts of water; the thickener is made of guar gum and propylene glycol alginate in a weight ratio of 1:4 Composition, described plasticizer is made up of glycerin and triethyl citrate by weight 2:3.

[0048] Preparation:

[0049] S1 Grind chitosan oligosaccharide, microcrystalline cellulose, calcium stearate and micropowdered silica gel into fine powder, add 5% povidone solution and absolute ethanol, mix evenly, and pass through a 20-mesh sieve to obtain fin...

Embodiment 3

[0053] Embodiment 3, A kind of chitosan oligosaccharide capsule

[0054] Described content comprises following component and weight percentage thereof:

[0055] Chitooligosaccharide 85.5%, microcrystalline cellulose 4%, 5% povidone solution 4%, calcium stearate 2%, absolute ethanol 3% and micropowder silica gel 1.5%;

[0056] The capsule shell comprises the following components and parts by weight thereof:

[0057] 8 parts of hydroxypropyl starch, 4 parts of xanthan gum, 5 parts of thickener, 4 parts of plasticizer and 16 parts of water; Described thickener is made of guar gum and propylene glycol alginate by weight ratio 1.2:3.5 Composition, described plasticizer is made up of glycerin and triethyl citrate by weight ratio 3.5:2.

[0058] The preparation method is similar to Example 2.

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Abstract

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a chtiosnaoligosaccharide (COS) capsule and a preparation method thereof. The COS capsule comprises a content and a capsule shell. The content is mainly prepared from COS, microcrystalline cellulose, adhesive, calcium stearate, ethyl alcohol and superfine silica powder. The capsule shell is mainly prepared from hydroxypropyl starch, xanthan gum, a thickening agent, a plasticizer and water. The COS capsule is free from extraneous odor, and clean, tidy and smooth in appearance; both the weight deviation and the solubility of the COS capsule meet the related stipulations of Chinese pharmacopoeia. In addition, the capsule has good leakproofness and oxidation resistance, the problem that oxidation and moisture absorption can happen to COS easily is effectively solved, and long-term storage of the COS is facilitated.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a chitosan oligosaccharide capsule and a preparation method thereof. Background technique [0002] Chitooligosaccharide (chtiosnaoligosaccharide, COS) is a homopolymer or heteropolymer of glucosamine and N-acetylglucosamine linked by β-1,4 glycosidic bonds. COS is the only alkaline polysaccharide that exists in large quantities in natural sugars. In addition to the properties similar to chitosan, it also has the advantages of low viscosity, good water solubility, small molecular weight, easy absorption and utilization, and degradability. Its biological activity and function Properties are more superior than chitosan. A large number of studies have shown that COS has the functions of regulating blood sugar and blood lipids, anti-oxidation, anti-infection, enhancing immunity and anti-tumor. It is an ideal bioactive substance and has broad medical ap...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/722A61K47/36A61K47/38A61P3/06A61P3/10A61P3/04A61P39/06A61P31/00A61P37/04A61P35/00
CPCA61K9/48A61K31/722A61K47/36A61K47/38A61K9/4866A61K9/4816
Inventor 苏政权郭姣黄兰兰
Owner GUANGDONG PHARMA UNIV
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