Preparation method for Mongolian four-species elecampane inula root decoction superfine powder tablets, granules and capsules

An ultra-fine powder and ultra-fine pulverization technology, which is applied in the preparation of granules, capsules, and ultra-fine powder tablets of Mongolian Medicine Chagan Decoction, can solve the problems of inconvenience to take, the taste of Siwei Tu Muxiang powder is bitter, and it will stimulate the sense of taste, etc. To achieve the effect of convenient taking, promoting the dissolution rate and dissolution rate, and solving the poor taste

Inactive Publication Date: 2016-04-20
包保全
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since Siwei Tumuxiang Powder contains Sophora flavescens, the alkaloids in Sophora flavescens will stimulate the taste when decocted, making Siwei Tumuxiang Powder taste extremely bitter and inconvenient to take, especially for children

Method used

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  • Preparation method for Mongolian four-species elecampane inula root decoction superfine powder tablets, granules and capsules
  • Preparation method for Mongolian four-species elecampane inula root decoction superfine powder tablets, granules and capsules
  • Preparation method for Mongolian four-species elecampane inula root decoction superfine powder tablets, granules and capsules

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] This specific implementation adopts wet granulation and tabletting, and the disintegrating agent is added by internal addition.

[0030] Filler type and dosage selection

[0031] On the basis of the preliminary experiment, the fixed disintegrant was 5% carboxymethyl starch sodium (CMS-Na), the binder was 80% ethanol solution, the lubricant was 1.0% magnesium stearate, 0.5% micropowder silica gel and different Proportion Microcrystalline cellulose (MCC) is the filler. The optimal filler ratio was screened out based on the core appearance, hardness and disintegration time limit.

[0032] Take the prescription ratio of Siwei Tumuxiang superfine powder, filler and disintegrant, mix evenly, add an appropriate amount of binder to make a soft material, pass through a 20-mesh sieve to granulate, dry the wet granules in an oven at 60°C for 40 minutes, take them out, and use a 20-mesh sieve. After sieving and sizing, mix evenly with lubricant, and finally use a shallow round di...

Embodiment 2

[0055] Extraction process optimization research

[0056] In the process of raw material extraction process research, literature research was carried out on the four traditional Chinese medicinal materials of the prescription. According to the different physical and chemical properties of the active ingredients of the medicinal materials, the ethanol reflux extraction method and the steam distillation method, which are easy to mass-produce, were respectively adopted, and the optimal method was optimized by using an orthogonal design. craft.

[0057] Extraction of volatile oil by steam distillation

[0058] Orthogonal table design: choose to use water as the solvent for extraction, and screen the factors that affect the water extraction process, the amount of water added, the immersion time (normal temperature, normal pressure), and the number of times of decoction. The following 3 levels are designed for each factor, according to L9(34) conducted an orthogonal test (see Table ...

Embodiment 3

[0119] Extraction of volatile oil by steam distillation

[0120] Orthogonal table design: choose to use water as the solvent for extraction, and screen the factors that affect the water extraction process, the amount of water added, the immersion time (normal temperature, normal pressure), and the number of times of decoction. The following 3 levels are designed for each factor, according to L9(34) carried out an orthogonal test (see Table 16), and at the same time clarified the active ingredients and physical and chemical properties of each herbal medicine, and selected the best extraction conditions with the amount of volatile oil as the evaluation index.

[0121] Table 16 Orthogonal table

[0122]

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Abstract

The invention discloses a preparation method for Mongolian four-species elecampane inula root decoction superfine powder tablets, granules and capsules. A superfine grinding technology adopted the four-species elecampane inula root decoction superfine powder is based on the theory of breaking plant medicine cell walls and promoting dissolution and dispersion of ingredients in cells, and the dissolving-out quantity and speed of the ingredients in the plant cells in vivo or a solvent are increased to achieve the aims of improving the bioavailability of medicine, reducing the taking amount and improving preparation quality. Processes adopted in the four-species elecampane inula root decoction granules comprise the freeze-drying process, the beta-cyclodextrin inclusion process and the coating process. Effective ingredients are fully kept, and meanwhile the problems that the taste is poor, carrying is inconvenient, and taking is inconvenient are solved. Processes adopted in the four-species elecampane inula root decoction capsules comprise the freeze-drying process, the beta-cyclodextrin inclusion process and the capsule preparation process. The effective ingredients are fully kept, the defects of solid dosage forms are overcome, the bioavailability is improved, and meanwhile the problem that the taste is poor and other problems are solved.

Description

technical field [0001] The invention relates to the field of medicine preparation, in particular to a method for preparing Mongolian medicine Chagan Decoction superfine powder tablets, granules and capsules. Background technique [0002] The currently commercially available Siwei Tumuxiang powder is prepared by pulverizing the four medicinal materials of Tumuxiang, Sophora flavescens, Rubus chinensis and Shannai into coarse powder, sieving and mixing. The method of taking is decoction in water. Since Siwei Tumuxiang Powder contains Sophora flavescens, the alkaloids in Sophora flavescens will stimulate the sense of taste when decocted, making Siwei Tumuxiang Powder extremely bitter in taste and inconvenient to take, especially for children. Contents of the invention [0003] In order to solve the above problems, the invention provides a method for preparing Mongolian medicine Chagan Decoction superfine powder tablets, granules and capsules. [0004] In order to achieve th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/906A61K9/20A61K47/48A61K9/48A61K9/50A61K47/69
CPCA61K36/28A61K9/2009A61K9/2013A61K9/2054A61K9/2059A61K9/2893A61K9/4866A61K9/5042A61K36/489A61K36/73A61K36/906A61K2236/15A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 包保全张屏李玉棠陈建平宋宏春杭凌宇
Owner 包保全
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