Roxatidine acetate hydrochloride tablets and preparation method thereof

The technology of roxatidine hydrochloride acetate and filler is applied in the field of rosatidine hydrochloride acetate tablets and preparation thereof, which can solve the problems of drugs containing toxins, poor stability, side effects and the like, and achieve good tolerance , The preparation method is simple and easy, and the effect of preventing aspiration pneumonia

Inactive Publication Date: 2016-06-01
HEILONGJIANG ZHICHENG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] At present, there are various medicines for the treatment of gastric acid in the market, but most of them are slow...

Method used

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  • Roxatidine acetate hydrochloride tablets and preparation method thereof

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Comparison scheme
Effect test

Embodiment 1

[0032] A kind of roxatidine acetate hydrochloride tablet and preparation method thereof, main ingredient is roxatidine acetate hydrochloride 75mg, auxiliary material comprises filler, disintegrating agent, binding agent, lubricant composition, wherein the weight of various raw materials The percentages are 20-50% of the main material, 15-60% of the filler, 5-30% of the disintegrant, 0.1-20% of the binder and 0.01-3% of the lubricant.

[0033] The filler is one or a combination of microcrystalline cellulose, starch, pregelatinized starch, lactose, dextrin, and sucrose.

[0034] The disintegrating agent is one or more of low-substituted hydroxypropyl cellulose, sodium starch glycolate and croscarmellose sodium.

[0035] The binder is starch slurry or povidone k30 or hypromellose.

[0036] Described lubricant is the mixing of one or two in magnesium stearate, sodium lauryl sulfate.

Embodiment 2

[0038] A kind of roxatidine hydrochloride acetate tablet and preparation method thereof, the concrete steps of its preparation method are:

[0039] Step 1, select roxatidine hydrochloride acetate, filler, disintegrant, binding agent, lubricant by weight percentage, cross 80 mesh sieves respectively, for subsequent use;

[0040] Step 2. Mix the screened roxatidine hydrochloride acetate, filler and disintegrant evenly, put the mixed raw and auxiliary materials into the wet granulator, put the binder into the liquid supply tank, and turn on the Machine, adjust the parameters, open the shear flying knife at the same time, 2-5 minutes, discharge, use the swing granulator, pass through the 18-mesh nylon screen to granulate;

[0041] Step 3, place the wet granules in a fluidized bed coating machine, and dry at an inlet air temperature of 50°C;

[0042] Step 4, sizing the dry particles with a 16-mesh steel sieve;

[0043] Step 5, add lubricant, place in a three-dimension...

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Abstract

The invention relates to roxatidine acetate hydrochloride tablets and a preparation method thereof. A main material comprises roxatidine acetate hydrochloride, and an auxiliary material comprises a filler, a disintegrating agent, an adhesive and a lubricant, wherein the raw materials in weight percentage are 20-50% of the main material, 15-60% of the filler, 5-30% of the disintegrating agent, 0.1-20% of the adhesive, and 0.01-3% of the lubricant. A roxatidine acetate hydrochloride tablets histamine H2 acceptor antagonist has the advantages of long-acting, good tolerance, and no anti-male hormone effect, has no harm to drug metabolism for liver, can be used for treating gastric ulcer, duodenal ulcer, marginal ulcer, zollinger-ellison syndrome, and reflux esophagitis, and can be used for administration before anaesthesia so as to prevent aspiration pneumonia, the tablets are prepared, the preparation method is easy and simple to be carried out, and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a roxatidine hydrochloride acetate tablet and a preparation method thereof. Background technique [0002] Peptic ulcer (peptic ulcer) mainly refers to chronic ulcers that occur in the stomach and duodenum. It is a frequently-occurring disease and a common disease. There are various factors in the formation of ulcers, among which the digestion of mucous membrane by acidic gastric juice is the basic factor in the formation of ulcers, hence the name. Any site in contact with acidic gastric juice, such as the lower esophagus, anastomosis after gastrointestinal anastomosis, jejunum, and Meckel's diverticulum with ectopic gastric mucosa. The vast majority of ulcers occur in the duodenum and stomach, so they are also called gastric and duodenal ulcers. [0003] (1) Characteristics of peptic ulcer pain [0004] 1. Long-term because the ulcer can heal itself after the occu...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/4453A61K47/38A61K47/36A61P1/04A61P11/00
Inventor 张昕
Owner HEILONGJIANG ZHICHENG MEDICAL TECH
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