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Tea-seed oil fat emulsion injection and preparing method and application thereof

An injection and a technology for injection, applied in the direction of oil/fat/wax non-active ingredients, emulsion delivery, pharmaceutical formulations, etc., to increase stability and resist lipid peroxidation, accelerate lipid metabolism, and oleic acid content high effect

Inactive Publication Date: 2016-06-01
GUANGZHOU HANFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are currently no relevant patents and literature reports about the preparation method and use of tea seed oil fat emulsion injection

Method used

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  • Tea-seed oil fat emulsion injection and preparing method and application thereof
  • Tea-seed oil fat emulsion injection and preparing method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Weigh 160g of tea seed oil and 40g of refined soybean oil for injection, add 12g of egg yolk lecithin, heat to 75°C and stir to dissolve the emulsifier, stir to obtain an oil phase; take 860ml of water for injection, add 22.5g of glycerin, stir and heat to 75°C to dissolve , to get the water phase. Then heat the oil phase and the water phase to 75°C and mix them, emulsify with a shear emulsifier for 5 minutes (1600 rpm) to obtain colostrum, and homogenize the colostrum with a micro-jet high-pressure homogenizer (pressure 5000 psi) three times, Adjust its pH to 8.0 with sodium hydroxide solution or hydrochloric acid solution, add water for injection to 1000ml, subpackage, fill with nitrogen, and sterilize at 115°C for 30 minutes to obtain tea seed oil fat emulsion. The average particle size of the emulsion is 345.3nm, the pH is 7.90, the ratio of oleic acid to the total fatty acid is about 60%, and other indexes meet the requirements of intravenous emulsion.

Embodiment 2

[0025] Weigh 140g of tea seed oil and 60g of refined corn oil, add 12g of soybean lecithin, heat to 75°C and stir to dissolve the emulsifier, add 0.05g of tocopherol, stir to obtain the oil phase; take 860ml of water for injection, add 17.6g of sorbitol, stir Heated to 75°C to dissolve to obtain an aqueous phase. Then heat the oil phase and the water phase to 75°C and mix them, emulsify with a shear emulsifier for 5 minutes (1600 rpm) to obtain colostrum, and homogenize the colostrum with a micro-jet high-pressure homogenizer (pressure 5000 psi) three times, Adjust its pH to 8.5 with sodium hydroxide solution or hydrochloric acid solution, add water for injection to 1000 ml, subpackage, fill with nitrogen, and sterilize at 115° C. for 30 minutes to obtain tea seed oil fat emulsion. The average particle size of the emulsion is 420.1nm, the pH is 8.90, the ratio of oleic acid to the total fatty acid is about 60%, and other indexes meet the requirements of intravenous emulsion. ...

Embodiment 3

[0027] Weigh 100g of tea seed oil and 100g of refined safflower oil, add 12g of soybean lecithin, heat to 65°C and stir to dissolve the emulsifier, add 1g of tocopherol, stir to obtain the oil phase; take 860ml of water for injection, add 22.5g of sorbitol, Stir and heat to 65°C to dissolve and obtain an aqueous phase. Then heat the oil phase and the water phase to 65°C and mix them, emulsify with a shear emulsifier for 5 minutes (1600 rpm) to obtain colostrum, homogenize the colostrum with a micro-jet high-pressure homogenizer (pressure 5000 psi) three times, Adjust its pH to 9.0 with sodium hydroxide solution or hydrochloric acid solution, add water for injection to 1000ml, subpackage, fill with nitrogen, and sterilize at 115°C for 30 minutes to obtain tea seed oil fat emulsion. The average particle size of the emulsion is 230.0nm, the pH is 8.50, the ratio of oleic acid to the total fatty acid is about 60%, and other indexes meet the requirements of intravenous emulsion.

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Abstract

The invention discloses tea-seed oil fat emulsion injection and a preparing method and application thereof. Each liter of injection water of the tea-seed oil fat emulsion injection is prepared from following components: 0.01-30kg of tea-seed oil, 0.01-20kg of injection long chain oil, 0.5-10kg of emulsifier, 0.1-15kg of isoosmotic adjusting agent and 0-0.50kg of antioxygen and an adjusted pH is 5.5-9.50. By reducing the proportion of omega-6 polyunsaturated fatty acids while increasing the proportion of omega-3 polyunsaturated fatty acids, compatibility of various fats is optimized, a lipid metabolism level is accelerated, and organism material metabolism and synthesis of protein are helped. The injection can be widely used for various patients of parenteral nutrition treatment and particularly suitable for the low-immunity and various infected patients.

Description

technical field [0001] The invention relates to a tea seed oil fat emulsion preparation technology and its application, in particular to a tea seed oil fat emulsion injection and its preparation method and application. Background technique [0002] Camellia seed oil, also known as tea oil, tea tree oil or camellia oil, is a vegetable oil obtained by pressing or extracting fat-rich seeds produced by Camellia oleifera or small-leaf camellia. Camellia seed oil is mainly composed of oleic acid, linoleic acid, linolenic acid and partially saturated fatty acids. The content of oleic acid in tea oil can reach more than 75%, polyunsaturated fatty acids such as linoleic acid and linolenic acid account for about 10%, and oleic acid is A safe fatty acid, which is extremely beneficial to the health of the human body, has the functions of lowering blood cholesterol, preventing cardiovascular diseases and inhibiting tumors. Linoleic acid, linolenic acid and other polyunsaturated fatty ac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/82A61K9/107A61K47/44A61P3/02A61P37/04
CPCA61K36/82A61K9/0019A61K9/107A61K47/44
Inventor 许文东蔡鸿飞袁诚关伟键刘菊妍李金华唐顺之牟肖男杨玉琼李继荣熊淑娴
Owner GUANGZHOU HANFANG PHARMA
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