Monoacylglycerols and fat-soluble nutrients for use in the treatment of maldigestion

A monoacylglycerol, nutrient technology, applied in the field of health and nutrition, can solve problems such as deficiency, and achieve the effect of enhancing absorption

Inactive Publication Date: 2016-06-08
NESTEC SA
View PDF1 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, despite the availability of dietary supplements, patients with malabsorption disorders often suffer from deficiencies in fat-soluble micronutrients such as fat-soluble vitamins

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Monoacylglycerols and fat-soluble nutrients for use in the treatment of maldigestion
  • Monoacylglycerols and fat-soluble nutrients for use in the treatment of maldigestion
  • Monoacylglycerols and fat-soluble nutrients for use in the treatment of maldigestion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0106] The concept was tested in a rat model of lipid maldigestion or malabsorption. use (ORLISTAT) to obtain dyspepsia or malabsorption conditions, is an inhibitor of pancreatic lipase and gastric lipase (lipostatin; see Figure 7 ). For 21 days, rats were fed with a long-chain polyunsaturated fatty acid (LC-PUFA) supplement consisting mainly of eicosapentaenoic acid (EPA). Fish oil was used as a source of triacylglycerols and different EPA glycerides were evaluated. Supplied at levels sufficient to reduce lipid absorption by 40% (ORLISTAT). will accept without (ORLISTAT) fish oil group was used as a positive control. Fatty acid profiles of erythrocyte lipids and plasma lipids were determined at different time intervals (D3, D7, D14 and D21). At the end of the experiment, the fatty acid profiles of the different tissues were determined.

[0107] The primary objective is to track EPA levels in red blood cell lipids and plasma lipids. The main comparisons evaluate...

Embodiment 2

[0111] This clinical study compared patients with Efficacy of sn-1(3) MAG and fish oil (TAG) to deliver EPA in humans with (ORLISTAT)-induced lipid dyspepsia disorder. Test and compare volunteers whose BMI is 37-40kg / m 2 And by (ORLISTAT) treatment to induce lipid dyspepsia or without (ORLISTAT) processing. The primary objective was to assess the accumulation of EPA in erythrocytes during a 21-day period of consumption as fish oil (TAG) or sn-1(3) MAG. Secondary objectives were to assess the accumulation of EPA in plasma over a 21-day period and to assess the pharmacokinetics of EPA after acute administration in the form of sn-1(3)MAG or TAG (AUC of chylomicrons at 10 hours postprandial ). see image 3 .

[0112] Table 1 Experimental group

[0113]

[0114] Pharmacokinetic results ( Figure 4 ) shows that, compared to fish oil and (ORLISTAT) treatment with sn-1(3)MAG and (ORLISTAT) treatment produced an acute effect that was statistically significant (p=0.0...

Embodiment 3

[0117] In vitro digestion to assess bioaccessibility of lipid fractions . Mock, or in vitro digestion, is a method used to assess the stability of lipid components such as fat-soluble vitamins and carotenoids and the partitioning of lipid components to form mixed bile salts during the stages of digestion (oral, gastric, and small intestinal stages). Modeling of the extent of the micellar fraction, a key step in the uptake of lipophilic substances. Partitioning of lipid components to form mixed bile salt micelles is also referred to as "bioaccessibility" and is expressed as the efficiency of micellization. Adjust the type of enzyme at each step as needed (eg, malabsorbed versus control) and as appropriate for the purpose (eg, TAG, MAG, vitamin, carotenoid).

[0118] In the procedure, fish oil was used as a source of triacylglycerol (TAG). Monoacylglycerol (MAG) was purchased from Cognis GmbH, Germany and mixed with sunflower oil at a ratio of 1:0.8 (w / w).

[0119] Triacylg...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

Compositions comprising monoacylglycerols (MAG), such as sn-1(3) MAG, and further comprising fat-soluble nutrients, such as fat-soluble vitamins and carotenoids, are administered to an individual having or at risk of maldigestion, such as maldigestion associated with chronic pancreatitis, cystic fibrosis, diabetes, pancreatic duct obstruction, a pancreatic tumor, or Shwachman-Diamondsyndrome (SDS). The compositions and the methods of using the compositions enhance absorption of fatty acids and the fat-soluble nutrients to address nutritional deficiencies due to maldigestion.

Description

Background technique [0001] The present invention generally relates to health and nutrition. More particularly, the present invention relates to nutritional compositions that promote the improvement of the nutritional status of patients with dyspepsia, such as those associated with chronic pancreatitis, cystic fibrosis, diabetes, pancreatic duct obstruction, pancreatic neoplasms, and Shue-Day syndrome. (SDS)-related dyspepsia) or absorption of fatty acids and fat-soluble nutrients in individuals at risk for dyspepsia. [0002] Lipids are normally consumed as triacylglycerols (TAGs). During digestion, pancreatic lipase is secreted from the pancreas. Pancreatic triglyceride lipase (PTL) is the main lipase in the human digestive system to hydrolyze dietary TAG molecules, converting TAG to diacylglycerol (DAG) and finally to monoacylglycerol (MAG) and free fatty acids. [0003] Bile salts secreted from the liver and stored in the gallbladder are released into the duodenum, wher...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/232A61P3/02A61K31/07A61K31/355A61K31/593
CPCA61K31/07A61K31/355A61K31/593A23L33/40A23L33/10A61K31/232A61K31/015A61P1/14A61P11/00A61P3/02A61P3/10A61K2300/00A23V2002/00
Inventor C·勒斯勒C·克鲁兹-赫尔南德斯
Owner NESTEC SA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap