Preparation method of chelidonine compound chlorotetracycline slow-release premix

Abstract

The invention discloses a preparation method of a chelidonine compound chlorotetracycline slow-release premix, belonging to the technical field of chlorotetracycline premix preparation. The preparation method comprises the following steps: grinding and sieving the medicinal material herba chelidonii and mixing with absolute ethyl alcohol; heating in water bath; performing reflux extraction and filtering to obtain filtrate; concentrating to obtain chelidonine paste; adding the substances such as chlortetracycline hydrochloride and starch, mixing and performing activation treatment; performing tableting treatment and grinding and sieving to obtain a chlorotetracycline granule intermediate; mixing polyvinyl alcohol with the chelidonine paste to obtain a wet material; mixing the wet material with the obtained chlorotetracycline granule intermediate and rounding; and drying to obtain the chlorotetracycline slow-release premix. The preparation method disclosed by the invention has the following beneficial effects: the preparation steps are simple, and the product is hard to hydrolyze and has good stability in an acid condition; and after the application, the effect lasts long, and the utilization rate is more than or equal to 24.5% higher than that of other products.

Description

technical field [0001] The invention relates to a method for preparing chlortetracycline sustained-release premix by compounding chelidonine, and belongs to the technical field of preparation of chlortetracycline premix. Background technique [0002] Chlortetracycline is a tetracycline drug with a broad antibacterial spectrum. It has inhibitory effects on Gram-positive bacteria, negative bacteria, spirochetes, rickettsia, mycoplasma, chlamydia, and some protozoa. It mainly inhibits the protein synthesis of sensitive microorganisms. Feed aureomycin is recognized as an effective feed additive, which can promote growth, improve feeding efficiency, reduce and avoid the occurrence of livestock and poultry diseases, and has certain effects on respiratory and intestinal pathogens when used in pig production. Premix refers to a powder or granular preparation prepared by uniformly mixing a drug with a suitable base. The premix is ​​administered with a certain drug concentration thro...

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved by the present invention: Aiming at the drawbacks that the currently prepared chlortetracycline premix has poor stability under acidic conditions, is easy to hydrolyze, has fast release speed after use, short duration of action, and low utilization rate, a After the celandine medicinal material is milled and sieved, mixed with absolute ethanol, heated in a water bath, extracted by reflux, filtered to obtain a filtrate, concentrated to obtain a chelidonine paste, and mixed with aureomycin hydrochloride, starch and other substances for activation treatment Finally, tableting treatment, milling and sieving to obtain aureomycin granule intermediate, polyvinyl alcohol and chelidonine paste were mixed to obtain a wet material, and then mixed with the obtained chlortetracycline granule intermediate for throwing After rounding, dry the method of making aureomycin slow-release premix, in order to achieve the purpose of reducing its release rate