Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

PH-stimulation responsive intelligent nano container and preparation method thereof

A nano-container and stimuli-response technology, applied in the field of material science, can solve the problems of supramolecular valve organism toxicity, inability to apply organisms, narrow application range, etc., achieve high sensitivity, wide application, and reduce corrosion effects

Inactive Publication Date: 2016-07-06
NANJING UNIV OF SCI & TECH
View PDF1 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, in the original assembly system, the assembled supramolecular valve is insoluble in water, so it can only play its response role by doping it in an environment containing organic solvents. Most organic solvents are harmful to organisms and the environment. It limits its application; in the original assembly system, some supramolecular valves have biological toxicity and cannot be applied to the living body, which limits the application of smart containers in the biomedical field; the reported controllable release The smart container is capable of responding to external stimuli including: photoirradiation, enzyme activity, specific binding, redox reactions, and pH
The first few stimulus response methods have long response time, cumbersome response process, narrow application range, sensitivity and other shortcomings

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • PH-stimulation responsive intelligent nano container and preparation method thereof
  • PH-stimulation responsive intelligent nano container and preparation method thereof
  • PH-stimulation responsive intelligent nano container and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 1. Preparation of Hollow Mesoporous Silica Microspheres

[0031] Dissolve 1.0g of acryloyloxyethyltrimethylammonium chloride (AETAC) in 390ml of deionized water, add 40g of styrene, stir mechanically at room temperature for 30min, then raise the temperature to 90°C, N 2 After degassing for 30min, add 2,2'-azobisisobutylamidine dihydrochloride (V-50, 10wt%, 10ml), under N 2 Protected and reacted at 90°C for 24h to obtain PS spheres.

[0032] With 0.8g cetyltrimethylammonium bromide (CTAB), 29gH 2 O, 12 g of ethanol, and 1 ml of ammonia water were mixed to form a homogeneous solution, and 10 g of PS (~9%) was added dropwise under vigorous stirring at room temperature. After the dropwise addition, oscillate ultrasonically for 15 minutes, then add 4.0 g of tetraethylorthosilicate (TEOS) dropwise into the mixture with a syringe pump, and react at room temperature for 48 hours after the dropwise addition. After the reaction, the solid was collected by centrifugation, washe...

Embodiment 2

[0041] 1. Preparation of Hollow Mesoporous Silica Microspheres

[0042] 0.1g hematite particle is dispersed in the mixed solution that comprises 200ml isopropanol, 40ml deionized water, 6ml ammonia water, mechanical stirring 30min, then add dropwise the (tetraethyl orthosilicate) TEOS of 143ul and the ( Octadecyltrimethoxysilane) C18TMS, it takes about 1h to add dropwise, and the above mixture is continuously stirred for 8h. The obtained solid was separated by centrifugation, washed several times with ethanol, and calcined at 550°C for 6h. Disperse the solid obtained above in aqueous HCl solution and react at 80°C for 20 h to remove the template Fe 2 o 3 . The resulting solid HMSs were washed and dried.

[0043] 2. Surface modification of hollow mesoporous silica microspheres

[0044] 200mg of HMSs was dispersed in 15ml of anhydrous toluene, and ultrasonically oscillated to maximize dispersion. Magnetic stirring, N 2 Exhaust for 1h, then dropwise add 400ul 3-chloropropy...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
concentrationaaaaaaaaaa
Login to View More

Abstract

The invention discloses a pH-stimulation responsive intelligent nano container and a preparation method thereof. Compared with other stimulation response, the pH-stimulation responsive intelligent nano container is simple in operation, is high in sensitivity and is wide in application. The nano container can be used in the field of biology. Gemcitabine and other medicine molecules can be adsorbed in hollow mesoporous silicon dioxide spheres, and can be carried to a special pathological cell for being released, thereby reducing toxicity on healthy cells due to the medicine. The nano container also can be used in the field of anti-corrosion coatings, wherein a corrosion inhibitor molecule can be adsorbed in a cavity in the hollow mesoporous sphere and the nano container is doped with the coating, so that when pH of external environment is changed to cause corrosion on the coating, the corrosion inhibitor molecules are automatically released for self-repairing damaged coating, thereby greatly reducing corrosion on metal, such as steel, and reducing unnecessary waste.

Description

technical field [0001] The invention belongs to the field of material science, in particular to a method for preparing a PH-stimulus responsive intelligent nano container. Background technique [0002] In the field of coatings, anti-corrosion coatings can reduce or prevent the chemical reaction caused by slight changes between the metal surface and its surrounding environment, and hinder the corrosion of metals. Most effective anti-corrosion coatings are organic substances, which contain oxygen, nitrogen, and sulfur. , phosphorus and aromatic compounds, these substances can promote the adsorption and film formation on the metal surface. However, anti-corrosion coatings containing these organic substances have many disadvantages, such as: containing organic substances such as sulfur, phosphorus, and aromatic compounds, which contain certain toxicity; long-term use will cause toxic effects on the human body, which is not conducive to human health and environmental protection. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/04A61K31/7068C09D5/08
Inventor 傅佳骏刘影刘梦阳王明东孙广平
Owner NANJING UNIV OF SCI & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com