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53 results about "Nanocontainer" patented technology

Nanoscale hollow polymeric vessels that have the potential to be utilized to selectively deliver hydrophobic drugs to specific sites within individual cells.

Preparation method and application of intelligent anti-corrosion coating capable of being automatically repaired

The invention discloses a preparation method and application of an intelligent anti-corrosion coating capable of being automatically repaired, and belongs to the field of metal corrosion prevention. The method comprises: firstly, preparing silicon dioxide mesoporous microspheres as nano containers; secondly, adsorbing L-histidine as a corrosion inhibitor into the silicon dioxide mesoporous microspheres; and finally, doping the silicon dioxide mesoporous microspheres adsorbing the inhibitor L-histidine into a mixture of epoxy resin and an epoxy curing agent, and coating a metal surface with the mixture to form an anti-corrosion coating. Stimulated by external acid or alkali, the corrosion inhibitor, namely L-histidine molecules, is quickly released from the silicon dioxide mesoporous microspheres and enters the coating, thereby effectively inhibiting corrosion. The silicon oxide mesoporous microspheres are used as the nano containers to pack the corrosion inhibitor, and are then added to the coating; in this way, the problem of compatibility of the corrosion inhibitor and the coating is solved, and uniform dispersion of the corrosion inhibitor in the coating is realized. The invention further discloses application of the anti-corrosion coating, prepared by using the method, in guardrails.
Owner:JIANGSU GUGELANSHAN PROTECTIVE FACILITIES CO LTD +2

Acid-base dual-response hollow mesoporous silica composite nano container, self-repairing anticorrosive coating and preparation method thereof

The invention discloses an acid-base dual-response hollow mesoporous silica composite nano container. The nano container comprises a hollow mesoporous silica sphere core, a corrosion inhibitor and a ZIF-8 nano valve, the corrosion inhibitor is loaded in the hollow mesoporous silica sphere core, and the ZIF-8 nanometer valve coats the outer surface of the hollow mesoporous silicon dioxide sphere core. The invention also discloses self-repairing anticorrosive paint and a preparation method thereof, the hollow mesoporous silica nano-container has acid-base dual response-release functions, the compatibility and dispersibility of the nano container in a coating can be effectively improved, and the performance of the coating is prevented from being damaged by agglomeration of the nano container.
Owner:HUNAN UNIV

Method for preparing self-healing coating based on environment-friendly nanometer container

The invention design a self-healing coating based on an environment-friendly nanometer container, and belongs to the field of metal corrosion-resistant coatings. A method for preparing the self-healing coating is characterized by comprising the following steps: alternately depositing chitosan and polyaspartic acid on the surface of a nanosilicon dioxide material by adopting a layer-by-layer self-assembly method, preparing the layer-by-layer self-assembled nanosilicon dioxide material into the environment-friendly nanometer container through centrifugation, deionized water washing and drying, mixing the environment-friendly nanometer container and a diluent according to a certain proportion, and conducting ultrasonic dispersion to obtain a component I; adding epoxy resin, a dispersing agent and a flatting agent into the component I, uniformly mixing, and adding a curing agent so as to obtain the uniformly dispersed self-healing coating. Raw materials used by the self-healing coating prepared by adopting the method is environment-friendly, cheap and easy to obtain; the capacity of a corrosion inhibitor in the nanometer container is large; in the micro broken area of the coating, the nanometer container loaded with the corrosion inhibitor can release corrosion inhibitor molecules to be adsorbed on the surface of metal to form a protecting film, so as to play a certain self-healing role.
Owner:QINGDAO AGRI UNIV

Acid/base double stimulation responsive nanometer container and preparation method thereof

The invention discloses an acid / base double stimulation responsive nanometer container and a preparation method thereof. According to the nanometer container, mesoporous nanometer silicon dioxide is adopted as a framework; a host-guest compound is formed based on host pillar[5]arene and a guest molecular chain 1,6-(1-(1-methyl)imida zolehexyl)hexamethylene diamine; a supramolecular valve is formed on the surface of a microsphere through modification; a metal corrosion inhibitor is loaded in the microsphere; under the action of pH stimulation, macrocyclic pillar[5]arene in the nanometer container can move, thereby achieving controllable release of the metal corrosion inhibitor; and after the metal corrosion inhibitor enters a coating, metal corrosion can be effectively inhibited. The nanometer container disclosed by the invention has the advantages that the function of response to various external stimuluses can be achieved; double response to acid / base stimulation can be achieved; and the prospect of application to the fields of drug delivery, intelligent anti-corrosive coating and the like is broad.
Owner:NANJING UNIV OF SCI & TECH

PH-stimulation responsive intelligent nano container and preparation method thereof

The invention discloses a pH-stimulation responsive intelligent nano container and a preparation method thereof. Compared with other stimulation response, the pH-stimulation responsive intelligent nano container is simple in operation, is high in sensitivity and is wide in application. The nano container can be used in the field of biology. Gemcitabine and other medicine molecules can be adsorbed in hollow mesoporous silicon dioxide spheres, and can be carried to a special pathological cell for being released, thereby reducing toxicity on healthy cells due to the medicine. The nano container also can be used in the field of anti-corrosion coatings, wherein a corrosion inhibitor molecule can be adsorbed in a cavity in the hollow mesoporous sphere and the nano container is doped with the coating, so that when pH of external environment is changed to cause corrosion on the coating, the corrosion inhibitor molecules are automatically released for self-repairing damaged coating, thereby greatly reducing corrosion on metal, such as steel, and reducing unnecessary waste.
Owner:NANJING UNIV OF SCI & TECH

PH/zinc ion and redox quadruple stimuli responsive nanocontainer and preparation method thereof

The invention discloses a pH / zinc ion and redox quadruple stimuli responsive nanocontainer and a preparation method thereof. The nanocontainer adopts silica nanoparticles as the skeleton, then a host-guest compound can be formed based on a host molecule pillar[5]arene and a guest molecule chain 2-[(2-aminoethyl)dithio]-N-phenoxybutane-ethylamine, the microsphere surface is modified with a supramolecular valve, and the microsphere is internally loaded with rhodamine B. PH / Zn<2+> can stimulate the movement of the macrocyclic molecule pillar[5]arene in the nanocontainer, when a reducing substance cuts off a disulfide bond, combination between the macrocyclic molecule and guest molecule can fail, thus realizing controlled release of RhB. The intelligent nanocontainer provided by the invention can realize the function of response to a variety of external stimuli, and can achieve response to pH / Zn<2+> and redox quadruple stimuli, thus having broad application prospects in drug delivery, intelligent anticorrosive coatings and other fields.
Owner:NANJING UNIV OF SCI & TECH

Preparation method of ion response type antibacterial and anticorrosive coating

The invention discloses a preparation method of an ion response type antibacterial and anticorrosive coating, which comprises the steps of firstly, preparing a SiO2 nano container through liquid phase mixing and reflux condensation, then mixing the nano material with an antibacterial agent, carrying out ultrasonic treatment to obtain a nano container loaded with the antibacterial agent, then packaging the nano container by adopting a FeIII-TA complex molecular film, finally, according to a basic method for preparing the coating, adding the functional filler into the matrix coating, then adding a coating additive, and stirring at a high speed to obtain the ion response type antibacterial and anticorrosive coating. The selected coating is a water-based coating, the antibacterial agent is triclosan (TCS), and the coating and the antibacterial agent have the characteristics of being green and environment-friendly and do not contain harmful components. In the using process, harm to the human body and the environment is avoided, and the coating has the characteristics of self-repairing, long antibacterial aging and excellent corrosion resistance.
Owner:XIAN UNIV OF TECH

1-hydroxyethylidene-1,1-diphosphonic acid intercalated zinc-aluminum hydrotalcite corrosion inhibitor and preparation method thereof

InactiveCN110760854AHas controlled release propertiesGood corrosion inhibitionZinc nitrateNanocontainer
The invention discloses a 1-hydroxyethylidene-1,1-diphosphonic acid intercalated zinc-aluminum hydrotalcite corrosion inhibitor and a preparation method thereof. The preparation method comprises the steps that a mixed salt solution of zinc nitrate and aluminum nitrate is prepared, a sodium hydroxide solution is prepared, the two type of solutions are added into 1-hydroxyethylidene-1,1-diphosphonicacid liquid dropwise, stirring while dropwise adding and water-bath heating are conducted, after dropwise adding is completed, reaction liquid is poured into a high-pressure reaction kettle, the high-pressure reaction kettle is placed in a vacuum drying oven for heat-preservation aging, the high-pressure reaction kettle is taken out of the vacuum drying oven and cooled to the room temperature, after centrifugal washing is conducted, centrifuged solid is placed in a vacuum drying box to be dried, and thus the 1-hydroxyethylidene-1,1-diphosphonic acid intercalated zinc-aluminum hydrotalcite corrosion inhibitor can be obtained. Hydrotalcite is taken as a nanotainer, thus the 1-hydroxyethylidene-1,1-diphosphonic acid intercalated zinc-aluminum hydrotalcite corrosion inhibitor has the sustained-and-controlled release characteristic, and the problem that the loss amount of medicament of the corrosion inhibitor is solved; and meanwhile, by utilizing the synergistic corrosion-inhibiting effect of the corrosion inhibitors such as zinc salt and 1-hydroxyethylidene-1,1-diphosphonic acid on a seawater medium, the good corrosion-inhibiting effect on the corrosion behavior of carbon steel in seawater is achieved.
Owner:TIANJIN UNIV

Nano container loaded with corrosion response agent, preparation method and application thereof

InactiveCN111218144APlay a corrosion self-warning effectPlay self-healing functionAnti-corrosive paintsEpoxy resin coatingsSodium phosphatesMesoporous silica
The invention discloses a nano container loaded with a corrosion response agent, a preparation method and application thereof. The preparation method of the nano container loaded with the corrosion response agent comprises the following steps of: mixing mesoporous silica with a dispersing solvent uniformly to form a silica dispersion liquid; then adding a corrosion response agent solution into thesilica dispersion liquid, mixing the substances uniformly, and carrying out post-treatment to obtain silica loaded with the corrosion response agent; and finally, uniformly mixing the silica loaded with the corrosion response agent with a chitosan solution, adding a sodium tripolyphosphate solution into the mixed solution, mixing the substances uniformly, and carrying out post-treatment to obtainthe nano container loaded with the corrosion response agent. A prepared bifunctional anticorrosive coating with corrosion self-early-warning and self-repairing functions is high in sensitivity, localcorrosion of a metal surface can be rapidly detected, and a corrosion inhibition film is formed at a corrosion interface to play a self-repairing role, therefore the nano container loaded with the corrosion response agent has good application prospects in material corrosion protection evaluation and detection.
Owner:NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI

Controlled-release magnetic ZnAlCe hydrotalcite loaded 2-mercaptobenzothiazole corrosion inhibitor and preparation method thereof

The invention provides a controlled-release magnetic ZnAlCe hydrotalcite loaded 2-mercaptobenzothiazole corrosion inhibitor and a preparation method thereof. With FeCl3.6H2O, crystalline sodium acetate, ethylene glycol, Zn(NO3)2.6H2O, Al(NO3)3.9H2O, Ce(NO3)3.9H2O, 2-mercaptobenzothiazole, NaOH and methyl alcohol as raw materials, an MBT-intercalated magnetic ZnAlCe hydrotalcite (Fe3O4@ZnAlCe-MBT LDH) corrosion inhibitor material is prepared through an ion exchange method. Through the nanocontainer effect of hydrotalcite and superparamagnetism of Fe3O4, by means of the ion exchange method, a 2-mercaptobenzothiazole-intercalated magnetic ZnAlCe hydrotalcite corrosion inhibitor material is synthesized; and meanwhile, by means of an applied magnetic field, the release behavior of the corrosioninhibitor is controlled, thereby improving the corrosion resistance of carbon steel and prolonging the service life of the carbon steel in a seawater cycle cooling system through the magnetic-controlled release behavior of the corrosion inhibitor.
Owner:TIANJIN UNIV

Hydrophobin mimics: process for preparation thereof

The present invention discloses hydrophobin mimics of formula (I) comprising a protein head group, hydrophilic linker and hydrophobic tail and to a process for synthesis of library of hydrophobin mimics thereof. The hydrophobin mimics of the present invention self-assemble to form protein nanoparticles / nanocontainer either alone or in a specified chemical environment. The hydrophobin mimics (I) of the present invention find application in area of bio-nanotechnology.
Owner:INDIAN INST OF SCI EDUCATION & RES

Method for preparing LDHs/GO-MA self-repairing anti-corrosion coating

The invention discloses a method for preparing an LDHs / GO-MA self-repairing anti-corrosion coating, which comprises the following steps of preparing magnesium-aluminum layered double hydroxides with a self-repairing function, modifying chitosan through thiocarbohydrazide, preparing a green and environment-friendly corrosion inhibitor, modifying graphene oxide by using maleic anhydride to obtain carboxylated graphene oxide, and finally, by utilizing esterification reaction, mixing liquid obtained by the esterification reaction with polyurethane to obtain a coating, and spraying the coating on the surface of a substrate. The magnesium-aluminum layered double-metal hydroxide is used as a nano container loaded modified chitosan corrosion inhibitor, the carboxyl content of the modified graphene oxide is increased, the modified graphene oxide is more easily subjected to esterification reaction with the modified chitosan and the magnesium-aluminum layered double-metal hydroxide, and the combination of self-repairing and the corrosion inhibitor enables a coating to have a stronger anti-corrosion effect; and the damaged surface can be quickly repaired after the coating is damaged due to the film-forming property of the phosphate ions, so that the self-repairing effect is achieved, and the service life of the coating is prolonged.
Owner:NANCHANG HANGKONG UNIVERSITY

Nanometer container and sol-gel coating based on ZIF-8 structure and preparation method of nanometer container and sol-gel coating

The invention relates to the technical field of high polymer materials, in particular to a nano container and a sol-gel coating based on a ZIF-8 structure and a preparation method of the nano container and the sol-gel coating. According to the invention, ZIF-8 nano-particles are used as a self-sacrifice template of HMSN, a pH response type'gate valve 'and an interface compatibility auxiliary agent, and a novel pH response type HMSN-BTA-ZIF-8 nano-container is designed. The HMSN-BTA-coated ZIF-8 is used as a substrate to prepare a sol-gel coating, and then the sol-gel coating is applied, so that metal corrosion can be effectively delayed. The obtained sol-gel coating (intelligent anticorrosive coating) has a potential self-healing effect, and compared with a traditional metal anticorrosive agent, the sol-gel coating is low in toxicity, small in pollution in the production process and environmentally friendly.
Owner:SHANGHAI INST OF TECH

Preparation method of hollow mesoporous silica\APS\graphene oxide nano container

ActiveCN111057442AWork around the limitation of only providing passive protectionGood dispersionAnti-corrosive paintsEpoxy resin coatingsEpoxyMesoporous silica
The invention provides a preparation method of a hollow mesoporous silica\APS\graphene oxide nano container. According to the invention, hollow mesoporous silica and aminopropyltrimethoxysilane are mixed for modification, then the modified hollow mesoporous silica is grafted to the surface of graphene oxide, and the hollow mesoporous silica\APS\graphene oxide nano container which has good dispersity in an epoxy coating and can load a corrosion inhibitor is prepared. According to the preparation method, the dispersity of the graphene oxide in the epoxy coating is improved, so that the service life of the graphene oxide epoxy coating is greatly prolonged. The limitation that graphene oxide can only provide a passive protection function in an epoxy coating is also solved, the graphene oxide is prepared into a nano container capable of loading a corrosion inhibitor, and the active corrosion protection function can provide long-acting corrosion protection for a metal substrate.
Owner:HARBIN ENG UNIV

Magnetic halloysite nanotube as well as preparation method and application thereof

The invention discloses a preparation method of a magnetic halloysite nanotube, which comprises the following steps: dispersing halloysite nanotubes used as a nano container in an organic iron solution by an organic iron method, conducting reacting in an oxygen-free environment, and carrying out in-situ synthesis on ferroferric oxide nanoparticles in the halloysite nanotubes, thereby forming magnetic halloysite. The magnetic halloysite is simple in preparation method, rich in raw material source and low in cost; and meanwhile, the surface property of the magnetic halloysite is not changed, andthe magnetic halloysite can be subjected to various surface modifications and is applied to the fields of biomedicine, chemistry, environmental science and the like.
Owner:深圳市犀锐生物科技有限公司

Layer-by-layer self-assembly pH response type silicon dioxide nano-container and preparation thereof, and application of silicon dioxide nano-container in composite silane film

PendingCN113444364AHas a self-healing effectInhibition of Corrosion ExpansionAnti-corrosive paintsMeth-Silicic acid
The invention relates to a layer-by-layer self-assembly pH response type silicon dioxide nano-container and preparation thereof, and application of the silicon dioxide nano-container in a composite silane film. A preparation method of the nano-container comprises the following steps: mixing hexadecyl trimethyl ammonium bromide, deionized water, ethyl alcohol, tetraethoxysilane and ammonia water, conducting centrifuging to obtain a solid phase, and performing calcination to obtain hollow silicon dioxide nanoparticles; mixing dispersed powder with a benzotriazole solution, and carrying out repeated vacuumizing by using a vacuum pump to obtain a particle loaded with a corrosion inhibitor; and depositing a polyelectrolyte shell on the outer layer of the obtained particle in an LbL mode to obtain the layer-by-layer self-assembly pH response type silicon dioxide nano-container. An obtained sample is added into a BTSE / KH-560 mixed silane solution for application. The prepared composite silane film has a potential self-healing effect, and compared with a traditional metal anti-corrosion agent, the composite silane film is low in toxicity, small in pollution in the production process and friendly to environment.
Owner:SHANGHAI INST OF TECH

Methionine-intercalated magnalium hydrotalcite nanocontainer and preparation method thereof

The invention provides a methionine-intercalated magnalium hydrotalcite nanocontainer and a preparation method thereof. The preparation method comprises the following steps: mixing Mg(NO3)2.6H2O and Al(NO3)3.9H2O according to a molar ratio of (2-3):1 to form a solution A; dissolving NaOH to form a solution B; mixing methionine and the Mg(NO3)2.6H2O according to a molar ratio of (2-3):5 to form a solution C; dropwise adding the solution A into the solution C, and adjusting the pH by using the solution B to keep the initial pH values of a mixed solution and the solution C constant, wherein the temperature is 30-35 DEG C; after completion of dropwise addition, continuing stirring the mixed solution for 30 minutes; heating the mixed solution to 60 DEG C, standing for aging for 5-8 hours, thencentrifuging an obtained suspension, repeatedly washing by using deionized water till a neutral state, and finally drying an obtained solid product at 60 DEG C for 25-30 hours. By the preparation method, the preparation process is simple, the cost is low, the operability is strong, the production cycle is short, and an inhibitor contained in the prepared nanocontainer is environmentally friendly,can be controllably released and has excellent repairing performance; the nanocontainer has a good prospect in the field of metal anticorrosion.
Owner:HARBIN ENG UNIV

Polymer-polymer composite nanoassemblies and applications thereof

The invention provides novel nanoscale delivery vehicles and composite nanoassemblies built from distinct nanoassembly units (e.g., block copolymer micelles and nanogels) with stoichiometric control. These intelligent composite nanoassemblies independently retain the key features of the nanoassembly units and greatly expand the potential functional features attainable based on the surface functionalization. The invention provides a novel approach to constructing nano-vehicles with controllable morphology based on combination of cooperative releasing mechanisms (e.g., redox sensitive nanogels and pH sensitive micelles). Two kinds of guests can be seperately and stably encapsulated in the composite nanocontainers, and then released sequentially under the stimulation of pH change and reduced glutathione.
Owner:UNIV OF MASSACHUSETTS

Dendronized alcoxyl ether polymer, modified gold nano microspheres thereof and preparation method thereof

The invention relates to dendronized alcoxyl ether polymer, modified gold nano microspheres thereof and a preparation method thereof. The gold nano microspheres are prepared by enabling the dendronized alcoxyl ether polymer with trithioester at the terminal to act with the surfaces of gold nanoparticles to form gold-sulfur bonds. The temperature-sensitive dendronized gold nano microspheres have the advantages of nanoscale and good monodispersity, a single microsphere can show temperature sensitive behaviors like quick dewatering collapse along with temperature rise, size of the microspheres becomes small, and the process is reversible. The surfaces of the temperature-sensitive dendronized gold nano microspheres contain large-size dendronized alcoxyl ether polymer, so that the microspheres have high capacity of loading micromolecular compounds and good biocompatibility, thereby having potential application value in the fields of biomedical materials, intelligent photoelectric materials and nano containers.
Owner:SHANGHAI UNIV

Nano container filler with multiple self-repairing and anti-corrosion functions and application of nano container filler

The invention discloses a nano container filler with multiple self-repairing and anti-corrosion functions, and a preparation method of the nano container filler mainly comprises the following two steps: firstly, preparing a hollow polyaniline capsule: adding vanadium pentoxide into deionized water, dropwise adding an aniline monomer and sulfuric acid, uniformly stirring and mixing in an ice bath, then adding an oxidizing agent, reacting in the ice bath, and obtaining a product C; dispersing the product C in a H2SO4 solution, carrying out stirring reaction at 90 DEG C for 24 hours, and carrying out centrifugal separation and drying to obtain the hollow polyaniline capsule; and secondly, preparing the nano container filler: combining the graphite-phase carbon nitride and the hollow polyaniline capsule to form a three-dimensional nano carrier, loading a BTA corrosion inhibitor on the nano carrier, and then coating the surface with a polydopamine layer to obtain the nano container filler which can be universally used in water-based paint. The waterborne epoxy coating and the nano container filler are selected to be compounded to form the coating. The composite coating has passivation and inhibition multiple self-repairing properties and high penetration resistance, and has a good metal protection effect.
Owner:SOUTHWEST PETROLEUM UNIV +1

Metal-based self-repairing coating as well as preparation method and application thereof

The invention provides a metal-based self-repairing coating as well as a preparation method and application thereof, and belongs to the field of electrodeposition micro-nano composite coatings and self-repairing. The metal-based self-repairing coating is composed of a metal coating and a nano container doped in the metal coating, the nano container takes a mesoporous material as a carrier, corrosion inhibitor molecules are supported inside the nano container, and a pH response material is modified on the surface of the nano container. The method comprises the following steps that firstly, a corrosion inhibitor is supported in the nano container, then surface hole sealing treatment is performed on the nano container containing the corrosion inhibitor by adopting a solution with the pH response, then the nano container is further modified through a cationic surface modification solution to enable the surface to have the certain positive charge, finally, a metal electrodeposition solutionis prepared, the nano container which contains the corrosion inhibitor and is provided with the pH response is added into the electrodeposition solution, co-deposition is realized under the action ofcurrent, and the metal coating with a self-repairing function is prepared. According to the metal-based self-repairing coating as well as the preparation method and application thereof, the protective life of the metal coating can be effectively prolonged, and a new idea is provided for preparing the novel metal composite coating.
Owner:725TH RES INST OF CHINA SHIPBUILDING INDAL CORP

Mesoporous carbon based nanocontainer coatings for corrosion protection of metal structures

A mesoporous carbon container comprising an embedded organic corrosion inhibitor and having an organic polymeric coating is described. Further described are a coating comprising such a container and a method for producing such a container.
Owner:KHALIFA UNIV OF SCI & TECH

Method of boron nitride nanoparticle fabrication for antitumor drug delivery

This invention relates to the technical field of nanomedical technologies, namely to the fabrication of nanocarriers of drugs for antitumor chemotherapy. The technical effects of the invention consistof increasing the efficiency of antitumor chemotherapy by increasing the activity of the cell absorption of nanocontainers loaded with an antitumor drug, avoiding of the nanocontainer toxicity for cells due to the use of dispersed boron nitride nanoparticles of 50-300 nm in diameter with a well-developed outer surface. The technical effects are achieved as follows. The method of boron nitride nanoparticles fabrication for antitumor drug delivery to tumor cells includes synthesis of spherical boron nitride nanoparticles of 50-300 nm in diameter with a well-developed outer surface by chemical vapor deposition using ammonia reaction gas, argon transport gas and powder mixture composed of amorphous boron and oxidizing reactants. Chemical deposition is carried out under the following conditions: 1000<=T<=1430, and 1.2<= Xi<=8, wherein T is the temperature of the powder mixture, the Xi is the ratio of the specific flows FAr / FNH3, the FAr is the specific flow of the transport gas and the FNH3 is the specific flow of the reactant gas. The ultrasonic treatment of BN nanoparticles agglomeration is realized followed by saturation of nanoparticles with antitumor drug by sorption and washing in distilled water.
Owner:FEDERALNOE GOSUDARSTVENNOE AVTONOMNOE OBRAZOVATELNOE UCHREZHDENIE VYSSHEGO OBRAZOVANIYA NATSIONALNYJ ISSLEDOVATELSKIJ TEKHNOLOGICHESKIJ UNIV MISIS

Preparation method of inorganic oxide pigment and filler loaded with composite corrosion inhibitor

The invention discloses a preparation method of an inorganic oxide pigment and filler loaded with a composite corrosion inhibitor, and belongs to the technical field of preparation of anticorrosive pigments and fillers. The inorganic oxide pigment and filler loaded with the composite corrosion inhibitor comprises a component A and a component B, wherein the component A is a composite corrosion inhibitor and comprises organic nitrogen azoles (such as diazoles, triazoles, tetrazoles and derivatives thereof), amine phosphate (ethanolamine phosphate, triethanolamine phosphate and the like) and inorganic trivalent cerium and phosphate compounds. The azole compounds have a good corrosion inhibition effect on nonferrous metals such as copper, aluminum, magnesium and alloys thereof, and the compounds such as amine phosphate and phosphate have a good corrosion inhibition effect on iron-based materials such as carbon steel and alloy steel; and the trivalent cerium compounds are used for promoting passivation of the base material. The problems that an existing inorganic pigment filler is poor in compatibility with an organic coating and has no self-repairing effect, and a micro-nano container is complex in preparation process, high in cost and the like are solved.
Owner:BEIJING UNIV OF CHEM TECH

Method of boron nitride nanoparticle fabrication for antitumor drug delivery

This invention relates to nanomedical technologies, namely to the fabrication of nanocarriers of drugs for antitumor chemotherapy. The technical result of the invention consists of increasing the efficiency of antitumor chemotherapy by increasing the activity of the cell absorption of nanocontainers loaded with an antitumor drug, avoiding of the nanocontainer toxicity for cells due to the use of dispersed boron nitride nanoparticles of 50-300 nm in diameter with a well-developed outer surface. The method of boron nitride nanoparticles fabrication for antitumor drug delivery to tumor cells includes synthesis of spherical boron nitride nanoparticles of 50-300 nm in diameter with a well-developed outer surface by chemical vapor deposition using ammonia reaction gas, argon transport gas and powder mixture composed of amorphous boron and oxidizing reactants.
Owner:NATIONAL RESEARCH TECHNOLOGICAL UNIVERSITY

Targeted liposomal delivery of cgmp analogues

ActiveUS20180085311A1Efficient deliveryPrevent unnecessary systemic exposureOrganic active ingredientsNanotechNanocontainerDisease
The invention relates to means and methods of targeted drug delivery of therapeutic agent to and across the blood-ocular barrier. In particular, the invention relates to cyclic guanosine-3′,5 ‘-monophosphate analogues as therapeutic agent for treating retinal diseases. The cGMPSs targeted to the blood-ocular barrier by glutathione-based ligands that facilitate the specific binding to and enhanced internalization by glutathione transporters present on the blood-ocular barrier. The glutathione-based ligands are conjugated to nanocontainers such as liposomes encapsulating the cGMPSs.
Owner:MIRECA MEDICINES GMBH

Corrosion inhibitor-loaded pH response type silicon dioxide nano-container composite silane film and preparation and application thereof

The invention relates to a corrosion inhibitor-loaded pH response type silicon dioxide nano-container composite silane film and preparation and application thereof.The preparation method comprises the following steps: firstly, mixing hexadecyl trimethyl ammonium bromide, deionized water, ethyl alcohol, tetraethoxysilane and ammonia water to obtain silicon dioxide nano-particles; treating the particles by using polyoxyethylene lauryl ether, zirconium butoxide, polyvinylpyrrolidone and sodium hydroxide to obtain nanoparticles with modified surfaces; mixing the dispersed powder with a 2-mercaptobenzothiazole solution, and repeatedly vacuumizing by using a vacuum pump to obtain particles loaded with the corrosion inhibitor; and adding the obtained product into a mixed solution of BTSE and KH-560 to obtain the corrosion inhibitor-loaded pH response type silicon dioxide nano-container composite silane film. Compared with a single silane film, the hybrid film with a nano-container shows higher long-term corrosion resistance and can be applied to corrosion protection of various metals.
Owner:SHANGHAI INST OF TECH
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