Pharmaceutical composition for treating heart failure with preserved ejection fraction and application of pharmaceutical composition

A heart failure and ejection fraction technology, applied in the field of medicine, can solve the problems of reducing myocardial infarction size and increasing the release of vascular endothelial relaxation factors, and achieve the effect of increasing patient compliance, reducing treatment costs, and reducing drug resistance.

Active Publication Date: 2016-07-13
SHANDONG UNIV QILU HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Mitochondrial acetaldehyde dehydrogenase 2 (ALDH2) is a key enzyme in the process of alcohol metabolism. In recent years, it has been reported that ALDH2 has a protective effect in myocardial ischemic postconditioning. By enhancing the expression of ALDH2, it can effectively reduce the size of myocardial infarction and play a role Myocardial protection (the role of mitochondrial acetaldehyde dehydrogenase 2 in myocardial ischemic postconditioning[J]. Chinese Pharmacology Bulletin, 2010,26(8):

Method used

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  • Pharmaceutical composition for treating heart failure with preserved ejection fraction and application of pharmaceutical composition
  • Pharmaceutical composition for treating heart failure with preserved ejection fraction and application of pharmaceutical composition
  • Pharmaceutical composition for treating heart failure with preserved ejection fraction and application of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0019] Example 1

[0020] 15 healthy Wistar male rats, weighing 200-220 g. After one week of adaptive rearing of the rats, 3 rats were randomly selected as the sham-operated group (the sham-operated group had the surgical silk thread passed through the abdominal aorta after laparotomy, but the abdominal aorta was not ligated), and the remaining 12 rats underwent abdominal surgery as follows: Aortic coarctation surgery to establish an animal model of heart failure with preserved ejection fraction: after skin preparation, rats were anesthetized with 3% sodium pentobarbital at 2.3ml / kg intraperitoneal anesthesia. The abdominal aorta was bluntly dissociated below the branch of the renal artery, the needle of a 9-gauge syringe was placed parallel to the abdominal artery, the abdominal aorta and the needle were ligated together with a 4-gauge surgical silk thread, and then the needle was slowly withdrawn to make the abdominal aorta of the rat The diameter is reduced by 35% to 40%, ...

Example Embodiment

[0028] Embodiment 2

[0029] The method is the same as in Example 1, except that the Alda-1 group is administered with 6 mg / kg of Alda-1 every day; the combination group is administered with 3 mg / kg of Alda-1 and 15 mg / kg of isosorbide mononitrate every day. .

[0030]The left ventricular systolic pressure and left ventricular end-diastolic pressure were detected by hemodynamics. The statistical results are shown in Table 1. Cardiac hypertrophy index was used to measure global cardiac mass index and left ventricular mass index. The statistical results are shown in Table 2.

[0031] It should be noted that, because the rats in the model control group did not take any treatment measures, the symptoms of heart failure gradually aggravated, and all died after 5 days. The Alda-1 group did not significantly improve the symptoms of heart failure in the rats. The heart failure symptoms of the rats in the combination group were significantly improved, and the concomitant symptoms of ...

Example Embodiment

[0039] Embodiment 3

[0040] The method is the same as that in Example 1, except that the Alda-1 group is administered with 90 mg / kg of Alda-1 every day; the combination group is administered with 45 mg / kg of Alda-1 and 15 mg / kg of isosorbide mononitrate. .

[0041] The left ventricular systolic pressure and left ventricular end-diastolic pressure were detected by hemodynamics. The statistical results are shown in Table 1. Cardiac hypertrophy index was used to measure global cardiac mass index and left ventricular mass index. The statistical results are shown in Table 2.

[0042] It should be noted that, because the rats in the model control group did not take any treatment measures, the symptoms of heart failure gradually aggravated, and all died after 10 days. The Alda-1 group did not significantly improve the symptoms of heart failure in the rats. The heart failure symptoms of the rats in the combination group were significantly improved, and the concomitant symptoms of h...

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Abstract

The invention discloses a pharmaceutical composition for treating a heart failure with preserved ejection fraction. The pharmaceutical composition comprises two active components: (1) activity factors of mitochondria acetaldehyde dehydrogenase 2 enzymatic activity; and (2) a nitrate medicine. According to the pharmaceutical composition, left ventricular end diastolic pressure is effectively reduced; the symptom of myocardial hypertrophy of a heart failure patient is improved; the heart failure with preserved ejection fraction is treated; meanwhile, the tolerance of the nitrate medicine when the heart failure with preserved ejection fraction is effectively reduced; and the effective dose of each single medicine is reduced, so that the incidence rate of the side effect of the medicine is relatively low; the treatment cost is also reduced; the benefit/cost ratio of treatment is obviously improved; the compliance of a patient is increased; the living quality is obviously improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a pharmaceutical composition for treating heart failure with preserved ejection fraction and application thereof. Background technique [0002] Chronic heart failure (referred to as heart failure) is a clinical syndrome in which ventricular filling or ejection ability is impaired due to structural or functional abnormalities of the heart. Its main clinical manifestations are dyspnea, fatigue and fluid retention. Chronic heart failure and its acute episodes are the severe and terminal stages of various heart diseases, and are also one of the leading causes of death in heart disease patients. According to whether the left ventricular ejection fraction (LVEF) is normal, heart failure can be divided into heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF). The prevalence and hospitalization rates of HFpEF have increased si...

Claims

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Application Information

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IPC IPC(8): A61K31/36A61K31/34A61P9/04
CPCA61K31/34A61K31/36A61K2300/00
Inventor 边圆
Owner SHANDONG UNIV QILU HOSPITAL
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