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Foaming agent with itching-relieving and inflammation-diminishing effects and preparation method of foaming agent

A foaming agent and technology of efficacy, applied in the field of foaming agent and its preparation, can solve the problems of incomplete absorption, skin discomfort, unsustainable effect, etc., and achieve the effects of enhancing the use effect, enhancing the cooling effect and the soft product

Active Publication Date: 2016-07-20
GUANGDONG HONGSHANHU PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because aerosol medicine can directly go to the action site or absorption site, it has very obvious quick-acting effect and localization effect, and is widely used due to the advantages of convenient use, but aerosol also has disadvantages, such as incomplete absorption and large variability, can be Cause local discomfort and irritation of the skin, and the liquid flows during use, the drug is easy to lose, and the effect is difficult to last, etc.
[0011] At present, foams are used in gynecological medicines, antipruritics, cosmetics and other fields, and there are relevant literature reports at home and abroad, but raw materials such as peppermint, camphor, aloe, eucalyptus oil and eugenol are used to prepare foams with antipruritic and anti-inflammatory effects. Agents have not been reported at home and abroad

Method used

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  • Foaming agent with itching-relieving and inflammation-diminishing effects and preparation method of foaming agent
  • Foaming agent with itching-relieving and inflammation-diminishing effects and preparation method of foaming agent
  • Foaming agent with itching-relieving and inflammation-diminishing effects and preparation method of foaming agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Embodiment 1: the selection of co-emulsifier

[0062] 1.1 Experimental method: Sodium lauryl sulfate, Tween-80, polyoxyl (40) stearate, triethanolamine, polyoxyethylene cetyl ether, alkyl glucoside, sorbitan lauric acid Equal amounts of the esters were weighed, and the Ross-Miles method was used, and the foam height change within 30 minutes after foaming was used as the evaluation index of foam stability. At the same time, since the formula of the foam agent matrix is ​​similar, the matrix formula of this patent is used as the matrix, and different surfactants are added to it, mixed evenly, poured into the aluminum tube, added with the same amount of propellant, and packaged. A sample size of 50 people was selected to conduct sensory tests on the foam softness and skin irritation of foams prepared with different surfactants.

[0063] 1.2 Ross-Miles determination of foam performance: At 40°C±0.5°C, 200mL sample solution flows down from a pore with a height of 900mm and ...

Embodiment 2

[0076] Embodiment 2: antipruritic effect experiment

[0077]1. Experimental method: get 50 guinea pigs, be divided into 5 groups at random: blank control group, positive control group (for Mentholatum Peppermint Ointment, dosage is 5ml / kg) and foam agent high, middle and low dosage groups of the present invention (dose respectively 10, 5, 2.5ml / kg), 10 rats in each group. Guinea pigs were depilated with 8% barium sulfide on their backs, and 24 hours later, the corresponding test drugs were administered percutaneously, and the blank control group was given corresponding blank matrix, once a day, for 5 consecutive days. 60 minutes after the last administration, scratch the shaved area with coarse sandpaper to make it red, with an area of ​​about 1cm×1cm, and add 0.01% histamine phosphate solution 0.05ml dropwise on the wound surface, and then Every 3min with 0.02%, 0.03%, 0.04%.. the concentration is increasing, each time 0.05ml per drop, until the guinea pig turns back to lick...

Embodiment 3

[0085] Embodiment 3: anti-inflammatory effect experiment

[0086] 1.1 Experimental method: Take 50 male mice and randomly divide them into 5 groups, namely blank control group (with the same dose of blank matrix), high, medium and low dose groups (with doses of 10, 5, 2.5ml / kg respectively ), positive control group (aspirin 100mg / kg). Each group was smeared on the abdomen of the mice respectively for 5 consecutive days, and the weight of the mice was recorded every day. One hour after the last administration, the two sides of the right auricles of the mice in each group were evenly smeared with xylene (0.05ml each). After 4 hours, the mice were sacrificed by dislocation of the cervical vertebrae. The ear pieces were removed from the same part of both ears, weighed with an electronic analytical balance, and the swelling value was obtained by subtracting the weight of the left ear piece from the weight of the right ear piece.

[0087] 2. Experimental results

[0088] 2.1 Inhi...

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Abstract

The invention discloses a foaming agent with itching-relieving and inflammation-diminishing effects and a preparation method of the foaming agent. The foaming agent comprises the following components in percentage by mass: 1-10% of natural menthol, 0.05-3% of natural camphor, 1-20% of tetrafluoroethane, 0.5-3% of aloe juice, 0.2-3% of eucalyptus oil, 0.2-3% of eugenol, 0.2-8% of a co-emulsifier, 8-15% of absolute ethyl alcohol, 15-30% of polyhydric alcohols, 0.1-5% of foam support components, 1-5% of glyceryl stearate and the balance of water. The foaming agent disclosed by the invention can be relatively well applied to skin inflammation, itching relieving, mosquito bite treatment and the like, and compared with a similar product, the foaming agent has the advantages of rapid absorption, rapid effect taking, good effect and the like, and is high in medicine release speed, high in bioavailability, free of skin irritation and convenient to carry and use.

Description

technical field [0001] The invention relates to a preparation method of a foam agent for human body with antipruritic and anti-inflammatory effects, and more particularly discloses a foam agent containing mint, camphor and the like and a preparation method thereof. Background technique [0002] The foaming agent refers to the ability to reduce the surface tension of the liquid and produce a large number of uniform and stable foams. The foaming agent can make its aqueous solution produce a large amount of foam when mechanical force is introduced into the air. Foam has the advantages of local treatment, deep administration, better spreading effect, prolonging the action time of the product on the lesion site, and increasing the bioavailability of active substances. [0003] The essence of the foaming agent is its surface activity. Surface activity is at the heart of foaming. There are many surfactants currently used for foaming, such as anionic surfactants, cationic surfacta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/886A61K36/896A61K9/12A61P17/04A61P29/00A61K31/085A61K31/045A61K31/125
CPCA61K9/0014A61K9/12A61K31/045A61K31/085A61K31/125A61K36/61A61K36/886A61K36/896A61K47/14A61K47/26A61K47/34A61K2300/00
Inventor 王高华李鹏飞张严源吴龙昊
Owner GUANGDONG HONGSHANHU PHARM CO LTD
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