A kind of pantoprazole enteric-coated pellets, pantoprazole enteric-coated sustained-release tablet and preparation method thereof
A pantoprazole enteric and solvent technology, applied in the field of medicine, can solve the problems of no pantoprazole sodium micro-pill tablets being marketed, the acid resistance of the micro-pill tablets cannot reach the standard, and the tablet deformation pressure cannot be tolerated, and the material can be improved. Uneven mixing of layers, high production efficiency and qualified acid resistance
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Embodiment 1
[0099] Drug layer
[0100]
[0101] Isolation layer
[0102]
[0103] Enteric layer
[0104]
[0105] outer coating layer
[0106]
[0107] tablet
[0108]
[0109] Among them, the substances with * are dried and removed during the process.
[0110] Prepare the coating solution for the drug layer, the coating solution for the isolation layer, the coating solution for the enteric layer, and the coating solution for the outer coating layer according to the prescription, and use a multifunctional fluidized bed in the laboratory to coat the drug layer and isolate the blank sugar pills in turn. layer, enteric-coated layer, and outer coating layer to obtain pantoprazole sodium enteric-coated pellets, wherein:
[0111] Based on the weight of the blank sugar pill, the weight gain of the drug-coating layer was 132.5%.
[0112] Based on the weight of the above drug pellets, the coating weight gain of the isolation layer is 25%.
[0113] Based on the weight...
Embodiment 2
[0117] Drug layer
[0118]
[0119] Isolation layer
[0120]
[0121] Enteric layer
[0122]
[0123] outer coating layer
[0124]
[0125] tablet
[0126]
[0127] Among them, the substances with * are dried and removed during the process
[0128] Prepare the coating solution for the drug layer, the coating solution for the isolation layer, the coating solution for the enteric layer, and the coating solution for the outer coating layer according to the place, and use the laboratory multifunctional fluidized bed to coat the blank sugar pills with the drug layer and the isolation layer in sequence. , enteric-coated layer, and outer coating layer to obtain pantoprazole sodium enteric-coated pellets, wherein:
[0129] Based on the weight of the blank sugar pill, the coating weight gain of the drug layer is 90%.
[0130] Based on the weight of the above drug pellets, the weight gain of the isolation layer coating is 15%.
[0131] Based on the weight of...
Embodiment 3
[0135] Drug layer
[0136]
[0137]
[0138] Isolation layer
[0139]
[0140] Enteric layer
[0141]
[0142] outer coating layer
[0143]
[0144] tablet
[0145]
[0146]
[0147] Among them, the substances with * are dried and removed during the process
[0148] Prepare the coating solution for the drug layer, the coating solution for the isolation layer, the coating solution for the enteric layer, and the coating solution for the outer coating layer according to the prescription, and use a multifunctional fluidized bed in the laboratory to coat the drug layer and isolate the blank sugar pills in turn. layer, enteric-coated layer, and outer coating layer to obtain pantoprazole sodium enteric-coated pellets, wherein:
[0149] Based on the weight of the blank sugar pill, the weight gain of the drug-coating layer was 182.5%.
[0150] Based on the weight of the above drug pellets, the coating weight gain of the isolation layer is 30%.
[01...
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