Method for preparing radix astragali temperature-sensitive gel for treating helicobacter pylori positive gastric ulcers
A technology of Helicobacter pylori and temperature-sensitive gel, which is applied in the directions of non-active ingredient medical preparations, active ingredients-containing medical preparations, pharmaceutical formulas, etc. Treatment requirements and other issues to achieve the effect of prolonging the stagnation time, maintaining drug concentration, and delaying drug release
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example 1
[0017] First weigh 5g of lecithin and add it to a 250mL beaker with 100mL of ethanol, stir for 3min to obtain an ethanol solution of lecithin; weigh 10g of astragalus and add it to a 500mL beaker, put the beaker into a water bath to keep the temperature at 36°C, and add Add 200mL of citrate buffer solution with a pH of 6 into the beaker, and add the lecithin ethanol solution dropwise at 5mL / min into the 500mL beaker while stirring, then put the beaker into an ice-water bath, control the temperature at 0°C, and react 2h, and then use 180w ultrasonic wave for 10min to obtain astragalus ethanolic plastid suspension; add 20g chitosan to the above astragalus ethanolic plastid suspension, control the temperature in the water bath at 65°C, stir for 10min, and then add 30mL Glycerin, 30mL poloxamer, controlled temperature at 65°C, stirred and reacted for 12h, cooled the reaction solution to room temperature naturally to obtain a gel; added 1g of potassium sorbate to the above gel, cont...
example 2
[0020] First weigh 8g of lecithin and add it to a 250mL beaker with 150mL of ethanol, stir for 4min to obtain an ethanol solution of lecithin; weigh 15g of astragalus and add it to a 500mL beaker, put the beaker into a water bath to keep the temperature at 38°C, and add Add 250mL of citrate buffer solution with a pH of 7 into the beaker, add the ethanol solution of lecithin mentioned above dropwise into the 500mL beaker at 6mL / min while stirring, then put the beaker into an ice-water bath, control the temperature at 3°C, and react 2.5h, then use 180w ultrasonic wave for 15min to obtain the astragalus ethanol plastid suspension; add 25g chitosan to the above astragalus ethanol plastid suspension, control the temperature in the water bath at 70°C, stir for 11min, and then add 40mL glycerin, 40mL poloxamer, control the temperature at 70°C, stir and react for 13h, naturally cool the reaction solution to room temperature, and obtain a gel; add 1.5g potassium sorbate to the above ...
example 3
[0023] First weigh 10g of lecithin and add it to a 250mL beaker with 200mL of ethanol, stir for 5min to obtain an ethanol solution of lecithin; weigh 20g of astragalus and add it to a 500mL beaker, put the beaker into a water bath to keep the temperature at 40°C, and add Add 300mL of citrate buffer solution with a pH of 8 into the beaker, and add the ethanol solution of lecithin mentioned above into the 500mL beaker dropwise at 8mL / min while stirring, control the temperature at 5°C in an ice-water bath, react for 3h, and then use a 200w ultrasonic wave to sonicate 20min, to obtain astragalus ethanol plastisome suspension; add 30g chitosan to the above suspension, control the temperature in a water bath at 75°C, stir for 12min, then add 50mL glycerin and 50mL poloxamer to it successively, control the temperature at Stir at 75°C for 14 hours, cool the reaction solution to room temperature naturally to obtain a gel; add 2 g of potassium sorbate to the above gel, control the temper...
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