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Temperature-sensitive self-repairing hydrogel and preparation method and application thereof

A self-healing and temperature-sensitive technology, which is applied in the field of temperature-sensitive self-healing hydrogel and its preparation, can solve the problems that temperature-sensitive hydrogel cannot achieve self-healing, etc., so as to prolong the service life, broad application prospects, good stability effect

Active Publication Date: 2016-08-17
HANDAN WARREN MORE TECHNICAL DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a thermosensitive self-healing hydrogel to solve the problem that the existing thermosensitive hydrogel cannot realize self-healing

Method used

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  • Temperature-sensitive self-repairing hydrogel and preparation method and application thereof
  • Temperature-sensitive self-repairing hydrogel and preparation method and application thereof
  • Temperature-sensitive self-repairing hydrogel and preparation method and application thereof

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preparation example Construction

[0046] The embodiment of the present invention also discloses a method for preparing a temperature-sensitive self-healing hydrogel, including the following steps:

[0047] a, copolymerization, 100 parts by weight of isopropylacrylamide and 5 to 400 parts (preferably 5 to 100 parts) of acrylate compounds are dissolved in a solvent, and free radical copolymerization (preferably living free radical polymerization) ), the reaction temperature is 30-120°C (preferably 60-100°C), the reaction time is 2-24h, preferably (12-24h), after the polymerization is completed, a precipitant is added to the reaction solution, and the residual monomer is removed by precipitation. (N-isopropylacrylamide)-acrylate copolymer was obtained. Among them, the acrylate compound is methyl acrylate, methyl methacrylate, ethyl acrylate, ethyl methacrylate, butyl acrylate, butyl methacrylate, hydroxyethyl acrylate or hydroxyethyl methacrylate One or more, preferably acrylate; the solvent used is N,N-dimethyl...

Embodiment 1

[0051] Copolymerization: 10g NIPAM, 1g methyl acrylate, 5mg azobisisobutyronitrile (AIBN) and 50mg DDMAT chain transfer agent (i.e. dodecyl trithiocarbonate) were dissolved in 15mL dioxane, and Add it into a 50mL reaction flask, remove the oxygen in the system, and raise the temperature to 60°C under magnetic stirring to carry out reversible addition-fragmentation chain transfer radical polymerization. The reaction time is 24h. After the reaction, cool the reaction system, and use petroleum ether Precipitate twice, remove unreacted monomer, and vacuum dry to obtain white powder, which is NIPAM-methyl acrylate copolymer. Calculate the monomer conversion rate and average molecular weight by weighing. The repeating unit NIPAM and repeating unit methyl acrylate in the copolymer The mass ratio is about 10:1.

[0052] Hydrazinolysis: Dissolve 5g of the above copolymer in a mixed solvent of 5mL ethanol and 10mL hydrazine hydrate, raise the temperature to 80°C, and perform hydrazinoly...

Embodiment 2

[0060] Copolymerization: 10g NIPAM, 40g methyl acrylate, 5mg azobisisobutyronitrile (AIBN) and 50mg CPDB chain transfer agent (i.e. cyanoisopropyl dithiobenzoate) were dissolved in 50mL dioxane, and Add it into a 100mL reaction bottle, remove the oxygen in the system, and raise the temperature to 60°C under magnetic stirring to perform reversible addition-fragmentation chain transfer radical polymerization. The reaction time is 24h. After the reaction is completed, cool the reaction system and use petroleum The ether was precipitated twice to remove unreacted monomers, and vacuum dried to obtain a light yellow powder, which was NIPAM-methyl acrylate copolymer. The monomer conversion rate and average molecular weight were calculated by weighing, and the mass ratio of the two repeating units in the polymer was about It is 1:4.

[0061] Hydrazinolysis: Dissolve 5g of the above-mentioned copolymer in 10mL of methanol, then add 10mL of hydrazine hydrate, heat up to 80°C, hydrazinol...

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Abstract

The invention provides temperature-sensitive self-repairing hydrogel and a preparation method and application thereof. The temperature-sensitive self-repairing hydrogel is formed by means of reaction of (N-isopropylacrylamide)-acrylhydrazine copolymer and a compound containing multiple carbonyl groups in an aqueous solution under the action of a catalyst, wherein the catalyst is a weak acid catalyst or an aniline catalyst, the (N-isopropylacrylamide)-acrylhydrazine copolymer comprises repetitive units A and repetitive units B, and the repetitive units A account for 20%-95% of the total mass of the copolymer. The hydrogel has temperature sensitivity and self repairability simultaneously and is good in stability, drug sustained release at different temperatures can be achieved, the hydrogel can achieve self repairing when subjected to damage, the self-repairing process is similar to that of a life body, and the hydrogel has very wide application prospects in biological medicine related fields such as artificial organs and biological indication and drug controlled release. Please see the formula in the description.

Description

technical field [0001] The invention relates to a hydrogel and its preparation method and application, in particular to a temperature-sensitive self-repairing hydrogel and its preparation method and application. Background technique [0002] Hydrogel is a gel with water as the dispersion medium. It is a polymer network system with soft properties, can maintain a certain shape, and can absorb a large amount of water. Hydrogel is to introduce some hydrophobic groups and hydrophilic residues into the water-soluble polymer with network cross-linked structure. The hydrophilic residues combine with water molecules to connect the water molecules inside the network, while the hydrophobic residues Cross-linked polymer that swells with water. [0003] Thermosensitive hydrogel is a kind of smart hydrogel that can reversibly respond to changes in environmental temperature. Poly(N-isopropylacrylamide) (PNIPAM) hydrogel is a widely used thermosensitive hydrogel. gel, the hydrogel underg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L33/24C08L33/08C08F220/54C08F220/14C08F220/18C08F8/32
CPCC08F8/32C08F220/18C08F220/54C08J3/075C08F2800/20C08F2810/20C08J2333/24C08J2333/08C08F220/1804C08F220/281
Inventor 秦江雷常瑞雪安恒李旭
Owner HANDAN WARREN MORE TECHNICAL DEV CO LTD
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