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Feather keratin-based biopolymer external application material and preparation method thereof

A feather keratin and biopolymer technology is applied to the preparation of feather keratin-based biopolymer external coating materials, the fields of rapid sterilization and anti-inflammatory for acute wounds and external dressing materials, and can solve the problems of restricting gelatin materials, insufficient thermal stability, difficult to control, etc. problems, to avoid wound fluid, eliminate wound odor, good antibacterial properties

Active Publication Date: 2016-08-24
大有药业扬州有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, through biological and clinical applications in recent years, it has been found that gelatin has many shortcomings as a biological material, such as low mechanical strength, fast biodegradation rate, difficult control, insufficient thermal stability, easy denaturation, etc., which seriously restrict the actual use of gelatin materials. application

Method used

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  • Feather keratin-based biopolymer external application material and preparation method thereof
  • Feather keratin-based biopolymer external application material and preparation method thereof
  • Feather keratin-based biopolymer external application material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Dissolve 5 g of feather keratin in 80 mL of 2 mol / L sodium hydroxide solution to obtain a feather keratin solution; dissolve 10 g of gelatin in 50 mL of distilled water, then add it to the feather keratin solution, and mix under stirring at room temperature Uniform; then add 0.8 g of 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride as a condensation agent, stir for 1 h, then add 0.5 g of N-hydroxysuccinimide as a condensation agent Auxiliary, adjust the pH value of the system to 5, stir for 2 h, then add 1.5 g sorbitol as a plasticizer, continue stirring for 1 h, after the reaction is completed, dialyze with distilled water for 24 h under dark conditions, then vacuum freeze After drying, the feather keratin grafted gelatin external dressing material is obtained.

[0048] The water absorption of the external application material reaches 37%, and its swelling rate reaches 440%. The swelling rate in saline solution reaches 475%, and the amount of saline solution...

Embodiment 2

[0050] Dissolve 1 g of feather keratin in 20 mL of 0.8 mol / L urea solution to obtain a feather keratin solution; dissolve 4 g of gelatin in 40 mL of distilled water, then add it to the feather keratin solution, and mix well under stirring at room temperature; Add 0.2 g of 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride as a condensation agent, stir for 1 h, then add 0.1 g of N-hydroxysuccinimide as a condensation aid , adjusted the pH value of the system to 6, stirred for 1.5 h, then added 0.5 g glycerol as a plasticizer, and continued to stir for 1 h. After the reaction was completed, it was dialyzed with distilled water for 20 h under dark conditions, and vacuum freeze-dried to obtain feathers. Keratin grafted gelatin external dressing material.

[0051] The appearance and properties of the external coating material are similar to Example 1.

Embodiment 3

[0053] Dissolve 10 g of feather keratin in 100 mL of 8 mol / L potassium hydroxide solution to obtain a feather keratin solution for use. Dissolve 50 g of gelatin in 200 mL of distilled water, add feather keratin solution, mix well under stirring at room temperature, then add 2 g of 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride as a condensation After stirring for 2.5 h, add 1 g of N-hydroxysuccinimide as a condensation aid, adjust the pH value of the system to 7, stir for 3 h, then add 5 g of maltitol as a plasticizer, continue stirring for 1 h, and react After the end, under the condition of avoiding light, dialyze with distilled water for 24 h, and then dry to obtain feather keratin grafted gelatin external coating material.

[0054] The appearance and properties of the external coating material are similar to Example 1.

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Abstract

The invention provides preparation of a feather keratin-based biopolymer external application material. The preparation method comprises the steps that feather keratin is dissolved into dispersion liquid to prepare a feather keratin solution; gelatin is dissolved into distilled water and then added into the feather keratin solution, and the solutions are mixed to be uniform under stirring at room temperature; a condensing agent is added, stirring is conducted, then a condensing auxiliary is added, the pH value of the system is regulated to be 5-7, and stirring is continuously conducted; a plasticizer is added, and reacting under stirring is conducted for a certain time; after reacting is finished, dialyzing is conducted with distilled water for 18-36 h under the dark condition, freeze drying is conducted, and then the biopolymer external application material is obtained. The biopolymer external application material is a spongy solid material, and a microporous sheet structure is arranged in the material; the good flexibility, adsorptivity, water-retaining property and vapor permeability are achieved. Antibacterial property and external releasing research shows that the material has the good bacteriostatic property and the quick releasing effect on micromolecular model drugs and is expected to be applied to the biomedicine field by serving as a quick sterilizing and inflammation diminishing external application material for acute wounds.

Description

technical field [0001] The invention belongs to the field of biotechnology, and relates to a preparation method of a feather keratin-based biopolymer external application material, which is mainly used as a drug carrier for rapid sterilization and anti-inflammation of acute wounds and external application materials. Background technique [0002] my country is extremely rich in feather keratin resources, and the development of large-scale poultry farming has produced a large amount of feather waste, of which only a small part is utilized, and most of the feather waste is only disposed of by landfill or incineration. This not only causes a waste of feather keratin resources, but also causes local environmental pollution, and does not conform to the concept of sustainable development and circular economy. [0003] Keratin is a kind of hard protein, which contains more cystine, so there are many disulfide bridges (-S-S-) in its protein chain, so keratin has stable chemical prope...

Claims

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Application Information

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IPC IPC(8): A61L15/32A61L15/42
CPCA61L15/32A61L15/42A61L15/425A61L2400/04C08L89/04C08L89/06
Inventor 王荣民李涛何玉凤钱文珍王建凤
Owner 大有药业扬州有限公司
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