Feather keratin-based biopolymer external application material and preparation method thereof
A feather keratin and biopolymer technology is applied to the preparation of feather keratin-based biopolymer external coating materials, the fields of rapid sterilization and anti-inflammatory for acute wounds and external dressing materials, and can solve the problems of restricting gelatin materials, insufficient thermal stability, difficult to control, etc. problems, to avoid wound fluid, eliminate wound odor, good antibacterial properties
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[0046] Example 1
[0047] Dissolve 5 g feather keratin in 80 mL of 2 mol / L sodium hydroxide solution to obtain a feather keratin solution; dissolve 10 g gelatin in 50 mL distilled water, then add to the feather keratin solution, and mix at room temperature with stirring Uniform; then add 0.8 g 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride as the condensing agent, stir for 1 h, then add 0.5 g N-hydroxysuccinimide as the condensation Additives, adjust the pH of the system to 5, stir for 2 h, then add 1.5 g of sorbitol as a plasticizer, continue to stir for 1 h, after the reaction is over, dialyzed with distilled water for 24 h in the dark, then freeze in vacuo Dry to obtain feather keratin grafted gelatin external coating material.
[0048] The water absorption of the external application material reaches 37%, and its swelling rate reaches 440%. The swelling rate in the salt solution reaches 475%, and the amount of salt solution absorbed reaches more than 40%. Water r...
Example Embodiment
[0049] Example 2
[0050] Dissolve 1 g of feather keratin in 20 mL of 0.8 mol / L urea solution to obtain a feather keratin solution; take 4 g of gelatin in 40 mL of distilled water, then add it to the feather keratin solution, and mix well under room temperature stirring; Then add 0.2 g of 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride as condensing agent, after stirring for 1 h, add 0.1 g of N-hydroxysuccinimide as condensation assistant Adjust the pH value of the system to 6, stir for 1.5 h, then add 0.5 g glycerin as a plasticizer, continue to stir for 1 h, after the reaction is over, dialyzed with distilled water for 20 h under dark conditions, vacuum freeze-drying, and feathers Keratin grafted gelatin external application material.
[0051] The appearance and various properties of the external application material are similar to those of Example 1.
Example Embodiment
[0052] Example 3
[0053] Dissolve 10 g of feather keratin in 100 mL of 8 mol / L potassium hydroxide solution to obtain a feather keratin solution, and set aside. Dissolve 50 g of gelatin in 200 mL of distilled water, add the feather keratin solution, mix well under stirring at room temperature, and then add 2 g of 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride as the condensation Mixture, after stirring for 2.5 h, add 1 g of N-hydroxysuccinimide as a condensation aid, adjust the pH of the system to 7, and stir for 3 h, then add 5 g of maltitol as a plasticizer, and continue to stir for 1 h. After the completion, under the dark condition, it was dialyzed with distilled water for 24 hours and then dried to obtain feather keratin grafted gelatin external coating material.
[0054] The appearance and various properties of the external application material are similar to those of Example 1.
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