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An oil-water biphasic collagen dressing especially suitable for dry skin

A collagen and water-phase technology, applied in skin care preparations, cosmetic preparations, bandages, etc., can solve the problems of collagen transdermal absorption speed, etc. The effect of improving the skin absorption rate

Active Publication Date: 2019-05-31
SHAANXI GIANT BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, the studies so far have only focused on the transdermal absorption rate of collagen, but not on the transdermal absorption rate of collagen.

Method used

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  • An oil-water biphasic collagen dressing especially suitable for dry skin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Embodiment 1. Oil-water biphasic collagen dressing (0.05% complete macromolecular collagen, oil phase: water phase 1: 1.5)

[0059] Element:

[0060] ①Oil phase: Cetyl PEG / PPG-10 / 1 polydimethylsiloxane 4.0% (emulsifier), caprylic / capric triglyceride 13.0%, C12-15 alcohol benzoate 13.0%, poly Dimethicone 8.0%, Bentonite 0.6% (macromolecular polymer), Hydrogenated Castor Oil 0.5%, Tocopheryl Acetate 0.8%, Propylparaben 0.1%

[0061] ②Water phase: complete macromolecular collagen (0.05%), glycerin 5.0%, butanediol 3.0%, sodium chloride 0.8%, methylparaben 0.2%, so that the total amount is 100% water.

[0062] Process operation:

[0063] ①Use 0.05mol / L acetic acid to pre-dissolve the complete macromolecular collagen, and after complete dissolution, use 0.01mol / L sodium hydroxide solution to adjust its pH to 5.0-6.0, and adjust the volume to make the final concentration of the mother liquor 1%;

[0064] ②Mix the methylparaben and butanediol and heat until completely dis...

Embodiment 2

[0067] Example 2. Oil-water biphasic collagen dressing (0.1% human-like collagen, oil phase: water phase 1:1.4) Element:

[0068] ①Oil phase: Cetyl PEG / PPG-10 / 1 polydimethylsiloxane 5.7% (emulsifier), caprylic / capric triglyceride 13.0%, C12-15 alcohol benzoate 13.0%, poly Dimethicone 8.0%, Bentonite 0.6% (macromolecular polymer), Hydrogenated Castor Oil 0.5%, Tocopheryl Acetate 0.8%, Propylparaben 0.1%

[0069] ②Water phase: human-like collagen (0.1%), glycerin 5.0%, butanediol 3.0%, sodium chloride 0.8%, methylparaben 0.2%, making the total amount 100% water.

[0070] Process operation:

[0071] ① Mix methylparaben and butanediol and heat until completely dissolved, then add the rest of the water phase components, stir evenly, heat in a water bath to 80-85°C, and set aside;

[0072] ②Weigh the oil phase components, heat in a water bath to 80-85°C, and homogenize at 4000rpm for 2-3min until uniform. The heated water phase is then slowly added to the oil phase while stirri...

Embodiment 3

[0074] Embodiment 3. Oil-water biphasic collagen dressing (0.5% gelatin, oil phase: water phase 1:1.3)

[0075] Element:

[0076] ① Oil phase: cetyl PEG / PPG-10 / 1 polydimethylsiloxane 7.5% (emulsifier), caprylic / capric triglyceride 13.0%, C12-15 alcohol benzoate 13.0%, poly Dimethicone 8.0%, Bentonite 0.6% (macromolecular polymer), Hydrogenated Castor Oil 0.5%, Tocopheryl Acetate 0.8%, Propylparaben 0.1%

[0077] ②Water phase: gelatin (0.5%), glycerin 5.0%, butanediol 3.0%, sodium chloride 0.8%, methylparaben 0.2%, so that the total amount is 100% water.

[0078] Process operation:

[0079] ① Mix methylparaben and butanediol and heat until completely dissolved, then add the rest of the water phase components, stir evenly, heat in a water bath to 80-85°C, and set aside;

[0080] ②Weigh the oil phase components, heat in a water bath to 80-85°C, and homogenize at 4000rpm for 2-3min until uniform. The heated water phase is then slowly added to the oil phase while stirring con...

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Abstract

The invention relates to the field of medical / cosmetic apparatus, in particular to a collagen dressing which is capable of promoting rapid transdermal absorption of collagen. The collagen dressing disclosed by the invention consists of an oil-phase carrier, aqueous-phase drops distributed in the oil-phase carrier and collagen distributed in the aqueous-phase drops. The collagen dressing, which is capable of promoting the rapid transdermal absorption of the collagen, is more suitable for medical / cosmetic use, and the collagen dressing is applicable to medical or medical cosmetic fields.

Description

technical field [0001] The invention relates to a collagen dressing, in particular to an oil-water two-phase collagen dressing, and belongs to the field of cosmetic / medical equipment. Background technique [0002] Collagen, also known as collagen, is an important protein component of connective tissue that supports and protects the body. It is also the most abundant structural protein in many vertebrates and invertebrates. It provides mechanical strength to bones, tendons, cartilage and skin. Collagen is one of the most abundant proteins in mammals, accounting for about 20%-30% of the total protein in the body, and mainly exists in skin, bones, tendons, soft tissues, etc. Among them, about 70%-80% of the skin extracellular matrix is ​​collagen. Collagen has good biocompatibility, so it can be used in medical or cosmetic fields. [0003] From the perspective of biological activity, it is desirable to use as complete and large molecular weight collagen molecules as possible ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/32A61L15/34A61L15/20A61L15/26A61K8/65A61K8/92A61K8/891A61Q19/00
Inventor 范代娣马晓轩严建亚
Owner SHAANXI GIANT BIOTECHNOLOGY CO LTD