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Method for preparing slow-release antibacterial dressing

A slow-release, bacterial cellulose technology, used in medical science, absorbent pads, bandages, etc., can solve the problem of short duration of antibacterial, achieve the effect of simple operation, shorten the wound healing period, and promote wound healing

Inactive Publication Date: 2016-10-12
GUANGDONG TAIBAO MEDICAL SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Quaternary phosphonium salts have high-efficiency, broad-spectrum, and bactericidal effects, but as an organic small molecule antibacterial agent, the biggest shortcoming in the application process of quaternary phosphonium salts is that the antibacterial duration is short

Method used

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  • Method for preparing slow-release antibacterial dressing
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Examples

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Effect test

Embodiment 1

[0037] A preparation method of slow-release antibacterial dressing, the specific steps of the preparation method are as follows:

[0038](1) Treat bacterial cellulose with low-temperature plasma first, and then conduct plasma treatment in an air atmosphere. The voltage of the plasma is 140V, the vacuum degree is 150Pa, and the treatment time is 1min at room temperature; 2g is weighed and treated with low-temperature plasma. Dissolve bacterial cellulose in 100mL of 60wt% isopropanol solution by weight, add 10g of dodecyltriphenylphosphonium chloride solution with 5.0wt% by weight, stir at 40°C for 12h, then cool, and use Washing with acetone, and finally washing repeatedly with distilled water, drying at 70°C to obtain quaternary phosphonium salt / bacterial cellulose;

[0039] (2) Weigh 2g of quaternary ammonium chitosan, dissolve it in 100mL of distilled water, and prepare a quaternary ammonium chitosan solution, then add 0.2g of calcium chloride, stir evenly, and then add 0.5g...

Embodiment 2

[0044] A preparation method of slow-release antibacterial dressing, the specific steps of the preparation method are as follows:

[0045] (1) Treat bacterial cellulose with low-temperature plasma first, and then conduct plasma treatment in an air atmosphere. The voltage of the plasma is 140V, the vacuum degree is 150Pa, and the treatment time is 1min at room temperature; 2g is weighed and treated with low-temperature plasma. Dissolve bacterial cellulose in 100mL of 60wt% isopropanol solution by weight, add 10g of dodecyltriphenylphosphonium chloride solution with 5.0wt% by weight, stir at 40°C for 12h, then cool, and use Washing with acetone, and finally washing repeatedly with distilled water, drying at 70°C to obtain quaternary phosphonium salt / bacterial cellulose;

[0046] (2) Weigh 2g of quaternary ammonium chitosan, dissolve it in 100mL of distilled water, and prepare a quaternary ammonium chitosan solution, then add 0.2g of calcium chloride, stir evenly, and then add 0.5...

Embodiment 3

[0051] A preparation method of slow-release antibacterial dressing, the specific steps of the preparation method are as follows:

[0052] (1) Treat bacterial cellulose with low-temperature plasma first, and then conduct plasma treatment in an air atmosphere. The voltage of the plasma is 140V, the vacuum degree is 150Pa, and the treatment time is 1min at room temperature; 2g is weighed and treated with low-temperature plasma. Dissolve bacterial cellulose in 100mL of 65wt% isopropanol solution by weight, add 8.3g of tetradecyltriphenylphosphonium chloride solution with 6.0wt% by weight, stir at 40°C for 12h, then cool, first Washing with acetone, and finally washing repeatedly with distilled water, drying at 70°C to obtain quaternary phosphonium salt / bacterial cellulose;

[0053] (2) Weigh 2g of quaternary ammonium chitosan, dissolve it in 100mL of distilled water, and prepare a quaternary ammonium chitosan solution, then add 0.2g of calcium chloride, stir evenly, and then add 0...

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Abstract

The invention belongs to the field of medical dressings, and discloses a method for preparing a slow-release antibacterial dressing. The method comprises the following steps: loading a phosphonium salt on bacterial cellulose, and wrapping the bacterial cellulose loaded with the phosphonium salt, and functional assistant materials by quaternary ammonium salt chitosan and alginate after multi-crosslinking. The slow-release antibacterial dressing has a dual slow-release antibacterial function, is capable of killing and inhibiting bacteria for a long time, and has multiple effects of moisture preservation, ventilation, wound percolate absorption, rapid hemostasis, wound healing promotion and the like.

Description

technical field [0001] The invention relates to the field of medical dressings, in particular to a preparation method of a slow-release antibacterial dressing. Background technique [0002] Traditional dressings have low delivery efficiency, need to be replaced frequently, and are irritating to the skin. In recent years, a large number of basic research on drug sustained release and clinical treatment have verified the superior performance of sustained-release materials in drug release applications. In order to improve the therapeutic effect, reduce adverse reactions and replacement times, and meet the requirements of high efficiency, long-term effect, and low toxic and side effects, sustained-release dressings can be used. Sustained-release dressing is to combine active drug molecules with polymer carriers (or compound, encapsulate), and then inject them into biologically active bodies through diffusion, penetration and other control methods, and then release active drug m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/18A61L15/20A61L15/28A61L15/42A61L15/44A61L15/46
CPCA61L15/28A61L15/18A61L15/20A61L15/42A61L15/44A61L15/46A61L2300/102A61L2300/208A61L2300/404A61L2300/414A61L2300/418C08L5/04C08L5/08C08L1/02
Inventor 卢亢庄壮辉韦加娜唐汉颖
Owner GUANGDONG TAIBAO MEDICAL SCI TECH
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