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A kind of dental bacteriostatic restorative material based on hydroxyapatite and preparation method thereof

A technology of hydroxyapatite and repair material, which is applied in the fields of hydroxy compound active ingredients, medical science, prosthesis, etc. Good bacteria and biocompatibility

Active Publication Date: 2019-03-08
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these materials have their own shortcomings in material compatibility and long-term antibacterial effect.

Method used

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  • A kind of dental bacteriostatic restorative material based on hydroxyapatite and preparation method thereof
  • A kind of dental bacteriostatic restorative material based on hydroxyapatite and preparation method thereof
  • A kind of dental bacteriostatic restorative material based on hydroxyapatite and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] (1) Weigh 7.6g of triethyl phosphate and add it to 20mL of absolute ethanol, slowly drop 2.5mL of distilled water into the diluent at a rate of 10 drops / min, and stir vigorously for 24 hours to gradually hydrolyze the triethyl phosphate. Weigh 23.6g of calcium nitrate and dissolve it in ethanol solution to prepare a 2mol / L solution, and stir vigorously to completely dissolve the calcium nitrate. Then mix and stir the calcium nitrate ethanol solution and the hydrolyzed triethyl phosphate for 4 hours, and age for 40 hours. After melting and pressing at a high temperature of 1700°C, a flat sheet, that is, a hydroxyapatite matrix, is obtained.

[0039] (2) Weigh 0.3 g of polyethylene glycol (PEG) (polymerization degree: 50) and add it to 25 mL of ethanol solution in which 0.36 mg of capsaicin is dissolved, shake for 30-60 min, and take out the PEG after the capsaicin is saturated and adsorbed.

[0040] (3) Disperse the above 0.3 g capsaicin-adsorbed PEG into 10 mL of ethan...

Embodiment 2

[0043] (1) is exactly the same as step (1) in embodiment 1.

[0044](2) Weigh 1 g of PEGO (octadecylamine polyoxyethylene ether) and add it to 50 mL of ethanol solution in which 10 mg of capsaicin is dissolved. After shaking for 30-60 min, take out the PEGO after the capsaicin is saturated and adsorbed.

[0045] (3) Dissolve the above 0.5g of PEGO with capsaicin absorbed into 15mL of PDMS-PVMS copolymer (polydimethylsiloxane, polymethylvinyl) with a mass fraction of 10% (copolymer mass is about 1.47g) Block copolymer of siloxane, the degree of polymerization of each block is 25 and 75 respectively) in ethanol solution.

[0046] (4) Apply the mixed solution in (3) to 5 g of hydroxyapatite obtained in (1) by spraying. Put it into a vacuum drying oven with a temperature of 120°C to remove the solvent to obtain a new tooth antibacterial restorative material.

[0047] The structural formula of the above-mentioned PEG derivative PEGO is shown in formula 2:

[0048]

[0049] Fo...

Embodiment 3

[0051] (1) is exactly the same as step (1) in embodiment 1.

[0052] (2) Weigh 0.2 g of sf-PPTA (the structural formula is shown in Formula 3) and add it to 20 mL of ethanol solution in which 5 mg of capsaicin is dissolved. After shaking for 30-60 min, take out the sf-PPTA after saturated adsorption of capsaicin.

[0053] (3) Dissolve the above 0.2 g of sf-PPTA with capsaicin adsorbed into 10 mL of PS-b-(PDMS-r-PVMS) (polystyrene, polydimethylene) with a mass fraction of 8% (mass about 0.784 g) In the ethanol solution of polysiloxane and polymethylvinylsiloxane triblock copolymers, the degrees of polymerization of the three blocks are 20, 70, and 30, respectively. The synthesis steps are that styrene monomer initiates polymerization to form poly Styrene block, followed by addition of hexamethylcyclotrisiloxane monomer to initiate polymerization to form polydimethylsiloxane block, followed by addition of 1,3,5-trivinyl-1,3,5-trimethyl Cyclotrisiloxane monomer initiates polymer...

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Abstract

The invention relates to a hydroxyapatite-based bacteriostatic repair material used in the department of dentistry and a preparation method thereof. The hydroxyapatite-based bacteriostatic repair material comprises hydroxyapatite, polysiloxane or polystyrene-polysiloxane copolymer loaded on the hydroxyapatite and polyethylene glycol or a polymer with a PEG structure, wherein the polysiloxane or polystyrene-polysiloxane copolymer accounts for 5%-30% by mass of the hydroxyapatite, and the PEG or the polymer with the PEG structure accounts for 5%-35% by mass of the hydroxyapatite. The repair material for tooth growth has high mechanical strength, good biocompatibility and good antibacterial properties.

Description

technical field [0001] The invention belongs to the technical field of dental restorative materials, in particular to a hydroxyapatite-based dental antibacterial restorative material and a preparation method thereof, which can better inhibit the growth of oral bacteria. Background technique [0002] The oral cavity is an environment full of various microorganisms. Whenever the human body eats, the bacteria that enter the mouth along with the food will chemically react with the sugar in the food to produce acidic substances that corrode the teeth. In the past, the protective layer on the surface of the tooth will be destroyed by these substances, forming a relatively fragile plaque, and if it continues to deteriorate, it will form a cavity, that is, tooth decay. Tooth decay can lead to tooth decay and loss in severe cases. Therefore, it is very necessary to seek to grow and restore antibacterial tooth materials with similar tooth materials in the alveolar of missing teeth o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/045A61K31/695A61L27/12A61L27/14A61L27/18A61L27/50A61L27/54
CPCA61L27/12A61L27/14A61L27/18A61L27/50A61L27/54A61L2300/404A61L2430/12C08L83/04C08L87/00C08L71/02C08L51/08
Inventor 董丽杰陈卓陈顺陆志伟张扬赵广辉
Owner WUHAN UNIV OF TECH