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Taurine preparation method

A technology of taurine and taurine, which is applied in the preparation of sulfonic acid, preparation of sulfonate, chemical instruments and methods, etc., can solve the problem of increased labor intensity of sulfate solid waste, limitation of one-time extraction rate, and failure of normal production. and other problems, to achieve the effect of being beneficial to large-scale industrial production, improving the utilization rate of raw materials and product yield, and avoiding the generation of solid waste salt sodium sulfate

Active Publication Date: 2016-10-12
QIANGJIANG YONGAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Sulfuric acid and alkali will eventually be converted into sodium sulfate. With long-term accumulation, sodium sulfate will take away part of the taurine, resulting in material loss; at the same time, sodium sulfate will always exist in the mother liquor, so that when the crude taurine is centrifuged, the crude product Residual sulfate in the medium will easily cause the product sulfate to exceed the standard, and the sulfate in the mother liquor will easily block the cooler, heater, synthesis tower and high-pressure pipeline under the synthesis conditions of high temperature and high pressure, resulting in the failure of normal production ; At the same time, a large amount of sulfate solid waste increases labor intensity and is not easy to handle
② Due to the presence of sodium sulfate after neutralization, the extraction rate at one time is limited, so in the subsequent extraction process, taurine (H 2 NCH 2 CH 2 SO 3 H) After multiple extractions, a large amount of waste mother liquor will be produced, which not only causes waste of raw materials, low yield, but also pollutes the environment. At the same time, the concentration of mother liquor needs to consume a large amount of steam, which makes the energy consumption higher
③A large amount of solid waste sodium sulfate is produced, causing great pressure on environmental protection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Take 500 mL of sodium taurine aqueous solution with a mass percentage of 46% in a reaction flask, slowly add isethionic acid under stirring at room temperature until the pH is 5.5 to stop, lower the system temperature to 15°C and filter to obtain 216 g of crude taurine , the filtrate was moved into the reaction bottle, and then this filtrate was supplemented with 1710g of ammonia water with a concentration of 26.5%, heated to 250°C in a high-pressure reactor, and the pressure was 10MPa, reacted for 1 hour, cooled and discharged, evaporated to catch ammonia, and obtained 697g taurine Sodium acid solution. The taurine content was determined by HPLC, and the sodium isethionate content was determined by ion chromatography; the results are shown in Table 1, and the percentages in the table are all mass percentages.

[0044] Table 1

[0045]

Embodiment 2

[0047] Take 500 mL of the sodium taurine solution obtained in Example 1 in a reaction flask, slowly add isethionic acid to stop at pH 7.5 under stirring at room temperature, lower the temperature of the system to 15° C. and filter to obtain 229 g of crude taurine, and the filtrate Move it into the reaction bottle, then add 1700g of ammonia water with a concentration of 25.8% to the filtrate, heat it to 253°C in a high-pressure reactor, and the pressure is 10.5MPa, react for 1 hour, cool down and discharge, evaporate to catch ammonia, and get 615g of taurine sodium solution. The taurine content was determined by HPLC, and the sodium isethionate content was determined by ion chromatography; the results are shown in Table 2, and the percentages in the table are all mass percentages.

[0048] Table 2

[0049]

Embodiment 3

[0051] Take 500 mL of sodium taurine solution with a mass percentage of 46% in a reaction flask, slowly add isethionic acid under stirring at room temperature until the pH is 8.5 to stop, lower the temperature of the system to 15° C. and filter to obtain 223 g of crude taurine. The filtrate was moved into a reaction bottle, and then 1690 g of ammonia water with a concentration of 26.0% was added to the filtrate, heated to 256 ° C in a high-pressure reactor, and the pressure was 10.5 MPa, and reacted for 1 hour, cooled and discharged, and evaporated to catch ammonia to obtain 580 g of taurine Sodium acid solution. The taurine content was determined by HPLC, and the sodium isethionate content was determined by ion chromatography; the results are shown in Table 3, and the percentages in the table are all mass percentages.

[0052] table 3

[0053]

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Abstract

The invention provides a taurine preparation method which is characterized by comprising the following steps: (a) mixing isethionic acid with a taurine salt solution until the pH value of the system reaches 5.0-9.5; (b) separating the liquid phase and solid phase in the system, wherein the obtained solid phase is a crude product of taurine, and the obtained liquid phase is an isethionate solution; and (c) adding ammonia water into the obtained liquid phase for reacting to obtain an isethionate-containing solution. In the taurine preparation method, the problem caused by adjusting pH with sulfuric acid in traditional technology is avoided; by circularly utilizing the cation radical in isethionate and without introducing new raw material or reagent, the use of dangerous chemical raw materials is reduced, the production technology is greatly simplified, the utilization rate of raw materials and the product yield are increased, and the production cost is remarkably reduced.

Description

technical field [0001] The application relates to a method for preparing taurine, which belongs to the field of drug synthesis. Background technique [0002] Taurine is a non-protein amino acid. As a drug, it has the effects of anti-inflammatory, antipyretic, analgesic, anti-convulsant and lowering blood pressure. It has a good effect on infant brain development, nerve conduction, visual function improvement and calcium absorption. . Taurine has a series of unique functions on the cardiovascular system, can enhance physical fitness and relieve fatigue, so taurine is gradually widely used in medical, food and health care and other fields. [0003] Taurine can be prepared by biological extraction and chemical synthesis. The former is rarely used due to the influence of raw materials and cost; at present, ethanolamine esterification method and ethylene oxide method are mainly used in industrial production. Compared with ethanolamine esterification method, ethylene oxide metho...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C303/02C07C309/14
CPCC07C303/02C07C309/14C07C303/44C07C303/22C07C303/32C07C309/08
Inventor 陈勇方锡权李少波蒋小军
Owner QIANGJIANG YONGAN PHARMA
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