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Intravascular ion sensor and preparation method thereof

An ion sensor and blood vessel technology, applied in the field of intravascular ion sensors and its preparation, can solve the problems of lack of anticoagulation, inability to realize simultaneous detection of multiple electrolyte ions, sensor failure, etc., and achieve the effect of advanced detection methods

Active Publication Date: 2016-11-02
薛迎风
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, on the one hand, the existing sensors for electrolyte concentration detection do not have anticoagulant properties and cannot be used in the blood flow environment in living blood vessels. In the blood flow, a layer of thrombus will be formed on the surface of the sensor due to blood coagulation, which will affect the ion-selective membrane. The permeability of the sensor makes the sensor invalid; on the other hand, the existing sensors for electrolyte concentration detection can only be used to detect the concentration of one kind of ion, and it is usually impossible to realize the simultaneous detection of multiple electrolyte ions.

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  • Intravascular ion sensor and preparation method thereof

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Effect test

Embodiment 1

[0050] In this embodiment, the intravascular biosensor, such as figure 1 As shown, including the internal core shaft is 316L, 0.7 mm diameter stainless steel wire 1, the surface of the stainless steel wire has a first layer of noble metal layer 2; the surface of the first layer of noble metal layer 2 has a first layer of ion selective membrane layer 3 and The first insulating layer 4, the first insulating layer 4 is connected end to end with the first layer of ion selective membrane layer 3 and coated on the outer surface of the first layer of noble metal layer 2, the tail of the first layer of ion selective membrane layer 3 is connected with The heads of the first insulating layer 4 are connected; the surface of the first insulating layer 4 has a second layer of noble metal layer 9, and the surface of the second noble metal layer 9 has a second layer of ion-selective membrane layer 10 and a second layer of insulating layer. Layer 11, the second insulating layer 11 is connecte...

Embodiment 2

[0063] The structure of the intravascular ion sensor of this embodiment is the same as that of Embodiment 1, the difference is that the diameter of the stainless steel wire in this embodiment is 0.6mm, and the first layer of noble metal layer, the second layer of noble metal layer, and the third layer of noble metal The thickness of the layer is 500nm; the thickness of the first insulating layer and the second insulating layer is 100μm; the thickness of the third insulating layer is 250μm; the length of the third insulating layer is 10mm; the first ion selective membrane layer, The thickness of the second ion selective membrane layer and the third ion selective membrane layer are both about 100nm, and the length is 6mm; the thickness of the polymer organic material layer is about 5nm. The thickness of the anticoagulant material layer is about 5nm.

[0064] Its preparation method is identical with embodiment 1.

Embodiment 3

[0066] The structure of the intravascular ion sensor of this embodiment is the same as that of Embodiment 1, the difference is that the diameter of the stainless steel wire in this embodiment is 0.75 mm, and the first noble metal layer, the second noble metal layer, and the third noble metal layer The thickness of the layer is 2000nm; the thickness of the first insulating layer and the second insulating layer is 500μm; the thickness of the third insulating layer is 1000μm; the length of the third insulating layer is 12mm; the first ion selective membrane layer, The thickness of the second ion selective membrane layer and the third ion selective membrane layer are both about 2000nm, and the length is 12mm; the thickness of the polymer organic material layer is about 50nm. The thickness of the anticoagulant material layer is about 50nm.

[0067] Its preparation method is identical with embodiment 1.

[0068] It should be noted that the polymeric organic material film layer in the...

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Abstract

The present invention relates to the field of medical instrument technology, more particularly, to an intravascular ion sensor and the preparation method thereof. The sensor comprises a conductive substrate and the surface of the conductive substrate is provided with a layer of precious metal. The surface of the precious metal layer is provided with an ion selection membrane layer, and the surface of the ion selection membrane layer is provided with a high-molecular organic material layer to have the ion selection membrane fixed. The surface of the high-molecular organic material layer is grafted with an anticoagulation material layer. According to the invention, through an ion selection membrane layer fixed by the high-molecular organic material layer evenly sprayed on the surface of the selection membrane layer and the anticoagulation material layer grafted on the surface of the high-molecular organic material layer, the sensor is provided with certain anticoagulation function, enabling it to have an anticoagulation performance after working for 10 to 20 hours in the blood current of a blood tube. And the sensor can be used directly in human blood vessels to detect the concentration of electrolyte without the occurrence of thrombosis occlusion in the effective time and provide a convenient and advanced detection solution to a citrate partial anticoagulation machine and other instruments for the online monitoring of blood components.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to an intravascular ion sensor and a preparation method thereof. Background technique [0002] In the process of clinical disease diagnosis and treatment, it is usually necessary to detect the concentration of electrolytes in the blood, such as calcium ions, potassium ions, pH, etc. At present, there are also some biosensors for detecting electrolytes in tissues or interstitial fluids. For example, the existing calcium ion sensor is an ion-selective electrode, which is a full-body sensor made by compounding a calcium ion-sensitive membrane on its substrate sensor. Solid state pin sensor. The sensor omits the internal reference electrode and the internal filling solution, and the sensor is placed in the solution to be tested as a working electrode, and forms a double-electrode system with an external reference electrode (saturated calomel electrode). When the sensor is used...

Claims

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Application Information

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IPC IPC(8): A61B5/145A61B5/1473
CPCA61B5/14503A61B5/14546A61B5/1473
Inventor 薛迎风
Owner 薛迎风
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