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A natural-rubber-based hot-melt pressure-sensitive adhesive and a preparing method thereof

A technology of hot-melt pressure-sensitive adhesive and natural rubber, which is applied in adhesives, pharmaceutical formulations, medical preparations with non-active ingredients, etc., and can solve the problems of decreased coating performance, increased cross-linking density of natural rubber, and unfavorable long-term operation of equipment, etc. , to achieve the effect of production efficiency without environmental pollution

Inactive Publication Date: 2016-11-09
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The molecular weight and distribution of natural rubber after mastication are not easy to control, and the later vulcanization process needs to be carried out under very strict vulcanization conditions, and the processing temperature is high. Excessive processing temperature is not conducive to the long-term operation of the equipment, and the high temperature makes some The temperature-sensitive additive becomes active, which will lead to an increase in the cross-linking density of natural rubber and a decrease in coating performance

Method used

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  • A natural-rubber-based hot-melt pressure-sensitive adhesive and a preparing method thereof
  • A natural-rubber-based hot-melt pressure-sensitive adhesive and a preparing method thereof
  • A natural-rubber-based hot-melt pressure-sensitive adhesive and a preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] As a comparison product, the polystyrene-isoprene-styrene (SIS-10) resin with an epoxy degree of 10% was used to prepare an ESIS-based hot-melt pressure-sensitive adhesive. The specific steps are as follows: 2 In an airtight container, the C5 petroleum resin of 85 parts by weight, the mineral oil of 40 parts by weight, the antioxidant tetrakis [β-(3,5-di-tert-butyl-4-hydroxyphenyl) of 1.5 parts by weight ) propionic acid] pentaerythritol ester and 55 parts by weight of polyethylene glycol resin were melt-mixed at 135°C for 15 minutes, then, 100 parts by weight of ESIS-10 was added, melt-mixed at 160°C for 20 minutes, and directly melt-coated , and its adhesion properties are shown in Table 1.

[0037] filled with N 2 In an airtight container, 7 parts by weight of the hydrophilic drug geniposide and 7 parts by weight of propylene glycol were added to the above-mentioned hot-melt pressure-sensitive adhesive, and melted and mixed at a temperature of 110° C. to prepare a d...

Embodiment 2

[0039] filled with N 2In an airtight container, the C5 petroleum resin of 85 parts by weight, the mineral oil of 40 parts by weight, the antioxidant tetrakis [β-(3,5-di-tert-butyl-4-hydroxyphenyl) of 1.5 parts by weight ) propionic acid] pentaerythritol ester and the Polyethylene Glycol resin of 55 parts by weight melted and mixed 15 minutes at 135 ℃, then, added 100 parts by weight ENR30-5g-PS8 (epoxy degree is 30%, grafting number is 5. The molecular weight of the branched chain is 8kg / mol), melted and mixed at 135°C for 20 minutes, and directly melted and coated. The adhesion performance results are shown in Table 1.

[0040] filled with N 2 In an airtight container, 7 parts by weight of the hydrophilic drug geniposide and 7 parts by weight of propylene glycol were added to the above-mentioned hot-melt pressure-sensitive adhesive, and melted and mixed at a temperature of 100 ° C to prepare a drug-containing hot-melt pressure-sensitive adhesive; At a temperature of 100°C, ...

Embodiment 3

[0042] filled with N 2 In an airtight container, the C5 petroleum resin of 85 parts by weight, the mineral oil of 40 parts by weight, the antioxidant tetrakis [β-(3,5-di-tert-butyl-4-hydroxyphenyl) of 1.5 parts by weight ) propionic acid] pentaerythritol ester and the Polyethylene Glycol resin of 55 parts by weight melted and mixed 15 minutes at 135 ℃, then, added 100 parts by weight ENR20-10g-PS5 (epoxy degree is 20%, grafting number is 10, the molecular weight of the branched chain is 5kg / mol), melted and mixed at 135°C for 20 minutes, and directly melt-coated. The results of the adhesion properties are shown in Table 1.

[0043] filled with N 2 In an airtight container, 7 parts by weight of the hydrophilic drug geniposide and 7 parts by weight of propylene glycol were added to the above-mentioned hot-melt pressure-sensitive adhesive, and melted and mixed at a temperature of 100 ° C to prepare a drug-containing hot-melt pressure-sensitive adhesive; At a temperature of 100°...

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Abstract

The invention discloses a natural-rubber-based hot-melt pressure-sensitive adhesive used for a rubber plaster patch and a preparing method thereof, and belongs to the technical field of hot-melt pressure-sensitive adhesives. The hot-melt pressure-sensitive adhesive and the method are characterized in that thermoplastic natural rubber used is a natural rubber graft copolymer, adopts an epoxidized natural rubber short chain after degradation and cutting as a main chain, and adopts thermoplastic polymer molecular chains as branches. The hot-melt pressure-sensitive adhesive comprises the natural rubber graft copolymer, tackifying resin, a plasticizer and an anti-oxidant. Beneficial effects of the hot-melt pressure-sensitive adhesive and the method are that the hot-melt pressure-sensitive adhesive is prepared by utilizing the natural rubber graft copolymer, and an organic solvent is not essential when the hot-melt pressure-sensitive adhesive is used for producing a rubber plaster patch, and therefore solvent volatilization and environment pollution are avoided, and a production efficiency is high.

Description

technical field [0001] The invention belongs to the technical field of hot-melt pressure-sensitive adhesives, and in particular relates to a natural rubber-based hot-melt pressure-sensitive adhesive for rubber plasters and a preparation method thereof. Background technique [0002] As a new type of drug delivery system, the transdermal drug delivery system can make the drug enter the systemic circulation through the skin at a nearly constant rate, and produce systemic or local therapeutic effects. Compared with other drug administration methods, it can avoid the discomfort caused by oral administration and the first-pass effect of the liver, and can overcome the adverse reactions caused by excessive blood drug concentration caused by excessive absorption. The drug administration is flexible, stable, and controllable. It is affected by factors such as pH value in the digestive tract and food. Because of its advantages such as convenient use, medication and drug withdrawal at...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09J151/04C09J157/02C09J11/08C09J11/06A61K9/70A61K47/32
CPCA61K9/7053C08L2205/035C09J11/06C09J11/08C09J151/04C09J157/02C08L57/02C08L71/00C08K5/1345C08L51/04
Inventor 赵忠夫张岩东张春庆周雍森
Owner DALIAN UNIV OF TECH