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A kind of preparation method of ethyl linolenate soft capsule

A technology of ethyl linolenate and soft capsules, which is applied in the field of preparation of ethyl linolenate soft capsules, can solve the problems of solvent residue, loss of product efficacy, high cost, etc., and achieve the effect of no toxic side effects

Active Publication Date: 2020-01-03
GANSU CHANGQING BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When applied to the purification of linolenic acid, these methods have defects such as complex process, high cost, loss of product efficacy, and potential safety hazards such as solvent residues.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The raw material is fresh linseed oil produced by a cold pressing method, and its α-linolenic acid content is 55 wt%.

[0023] (1) Pretreatment: Mix linseed oil, absolute ethanol and sodium ethylate in a mass ratio of 1:0.5:0.01, put them into a reaction tank, and stir at 60°C under reflux for 3 hours; distill off excess ethanol under reduced pressure; Based on the residual liquid after distillation, add 2wt% fatty acid sucrose ester, freeze and crystallize the crude α-linolenic acid at -10°C for 24 hours, and filter to obtain crude ethyl linolenic acid; adjust the pH with hydrochloric acid value to 6.5; washed with saturated brine, and separated the organic phase; dried in a vacuum desiccator to obtain refined ethyl linolenate.

[0024] (2) Molecular distillation: the refined ethyl linolenic acid can be obtained through four stages of molecular distillation to obtain a content of α-ethyl linolenic acid above 96wt%.

[0025] (3) α-linolenic acid soft capsule is a healt...

Embodiment 2

[0028] The raw material is fresh linseed oil produced by cold pressing method, and its α-linolenic acid content is 52wt%.

[0029] (1) Pretreatment: Mix linseed oil, absolute ethanol and sodium ethylate at a mass ratio of 1:0.55:0.011, put them into a reaction tank, and stir at 60°C under reflux for 3 hours; distill off excess ethanol under reduced pressure; Based on the residual liquid after distillation, add 1.5 wt% fatty acid sucrose ester, freeze and crystallize the crude α-linolenic acid at -10°C for 24 hours, and filter to obtain crude ethyl linolenic acid; The pH value reaches 7; washed with saturated brine, and the organic phase is separated; dried in a vacuum desiccator to obtain refined ethyl linolenate.

[0030] (2) Molecular distillation: the refined ethyl linolenic acid is subjected to four-stage molecular distillation to obtain a content of α-ethyl linolenic acid above 92wt%.

[0031] (3) α-linolenic acid soft capsule is a health food prepared with high content ...

Embodiment 3

[0034] The raw material is fresh linseed oil produced by a cold pressing method, and its alpha-linolenic acid content is 50 wt%.

[0035] (1) Pretreatment: Mix linseed oil, absolute ethanol and sodium ethylate at a mass ratio of 1:0.55:0.009, put them into a reaction tank, and stir at 60°C under reflux for 3 hours; distill off excess ethanol under reduced pressure; Based on the residual liquid after distillation, add 1.5 wt% fatty acid sucrose ester, freeze and crystallize the crude α-linolenic acid at -10°C for 24 hours, and filter to obtain crude ethyl linolenic acid; The pH value reaches 6.0; washing with saturated brine, and separating the organic phase; drying in a vacuum desiccator to obtain refined ethyl linolenate.

[0036] (2) Molecular distillation: the refined ethyl linolenic acid is subjected to four-stage molecular distillation to obtain a content of α-ethyl linolenic acid above 91 wt%.

[0037](3) α-linolenic acid soft capsule is a health food prepared with high...

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PUM

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Abstract

The invention provides a preparing method of ethyl linolenate capsules. The preparing method includes the following steps that 1, linseed oil, absolute ethyl alcohol and sodium ethoxide are mixed by the mass ratio of 1:(0.4-0.6):(0.008-0.012) and then put into a reaction tank, nitrogen is introduced at the temperature of 50-70 DEG C, and then the mixture is stirred in a reflux mode for 2-3 h; excessive ethyl alcohol is removed through reduced pressure distillation; sucrose fatty acid ester of 0.5-2% is added, freezing crystallization is carried out on an alpha-crude linolenic acid product for 10-24 h at the temperature of 0- minus 30 DEG C, the crude ethyl linolenate product is obtained through filtering; the pH value is adjusted to 6-7 with hydrochloric acid, the organic phase is separated through washing of saturated salt water, and the refined ethyl linolenate is obtained through drying; 2, purified ethyl linolenate is obtained through molecular distillation; 3, the purified ethyl linolenate serves as soft capsule content to prepare the ethyl linolenate capsules. High-purity ethyl linolenate is obtained through a series of combined processing, and sucrose fatty acid ester will not enter the final product.

Description

technical field [0001] The invention relates to a preparation method of ethyl linolenate soft capsules. Background technique [0002] α-linolenic acid is a polyunsaturated fatty acid, which is an important component of human brain cells and tissue cells. The human body cannot synthesize α-linolenic acid by itself and relies on diet to obtain it. After it enters the human body, it is catalyzed by enzymes. The conversion into eicosapentaenoic acid and docosahexaenoic acid plays an important role in preventing and curbing the three highs. [0003] The more commonly used methods for separating and purifying mixed fatty acids in the prior art are: (1) according to the difference in the solubility of fatty acids in organic solvents, there is a cryogenic crystallization method; (2) according to the unsaturated degree of unsaturated fatty acids, there is a urea inclusion method (3) According to the difference in the polarity of the fatty acid and the size of the attractive force wi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K31/232C07C67/03C07C67/54C07C69/587A61P29/00A61P7/02A61P3/06A61P9/08A23L33/115A23P10/30
CPCA23V2002/00A61K9/4825A61K31/232C07C67/03C07C67/54C07C69/587A23V2200/30A23V2200/326A23V2200/3262A23V2250/5432A23V2250/6406A23V2300/10
Inventor 谢小琴
Owner GANSU CHANGQING BIOLOGICAL TECH
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