Synthetic method of prothioconazole midbody 1-chloro-1-acetyl cyclopropane
A technology of prothioconazole and a synthetic method is applied in the new industrial synthesis field of 1-chloro-1-acetylcyclopropane, can solve the problems of high cost, high price of sodium ethoxide and butyrolactone, and achieves low cost, The effect of high reaction yield and cheap and easy-to-obtain raw materials
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[0038] 1. Production process:
[0039] 1. Synthesis of intermediate compound (2):
[0040] Add compound (1) (223.5g, 1.72 mol) and acetone (1100 ml) into a three-neck round bottom flask, add solid sodium iodide (12.9g, 0.086 mol), 1,2-dichloroethane (681g, 8.88 mol) and anhydrous potassium carbonate (285g, 2.06mol), the temperature was raised to 55°C under the protection of nitrogen, and the stirring was maintained for 24 hours in a slightly boiling reflux state. The gas phase detection reaction showed that the conversion rate of compound (1) was greater than 96%, and the solvent acetone was concentrated and recovered. and dichloroethane, the residue was extracted with tert-butyl methyl ether, filtered, the solid was washed, the filtrate was washed with brine, dried and concentrated, and distilled under high vacuum to obtain 265g of compound (2), the gas phase purity was greater than 97%, and the yield was 80% %.
[0041] 2. Synthesis of intermediate compound (3):
[0042] ...
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