Preparation method for hydrocolloid dressing for promoting wound repairing

A technology of wound repair and hydrocolloid, which is applied in medical science, bandages, absorbent pads, etc., can solve the problems of easy fluid leakage and peeling of dressings, small water absorption of dressings, and weak binding force, so as to promote wound healing, The effect of strong initial tack and strong stickiness

Active Publication Date: 2017-01-11
青岛华元精细生物制品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The main technical problem to be solved by the present invention is that the binding force between the hydrocolloid particles and the polymer film in the existing hydrocolloid dressing is not strong, the water absorption of the dressing is small, and the swelling property is poor, which leads to fluid leakage and peeling off of the dressing easily The present invention provides a kind of hydrocolloid dressing that can promote wound repair by mixing hydrophilic material with rubber elastic body to obtain fiber and cotton fiber to obtain wound repair. Add the AFGF freeze-dried powder into the mixture of gelatin and carboxymethyl chitosan to obtain a transparent liquid loaded with AFGF, mix it with the solution of sodium carboxymethyl cellulose, apple pectin, etc. Linking agent, carry out cross-linking reaction at a certain temperature, get the reaction solution and mix it with resin viscous solution to get spinning solution, use wet spinning to get loaded AFGF fiber, and mix it with pure cotton fiber to weave into cloth. The present invention improves the water absorption duration of the dressing and accelerates the gelation by adding apple pectin, and then effectively improves the viscosity and peel strength of the dressing by adding a styrene-isoprene block copolymer, and the present invention will The preparation of hydrocolloids into textile fabrics does not require a film substrate, which solves the problem of weak bonding between hydrocolloids and polymer films, can effectively promote wound recovery, and has broad application prospects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0023] First weigh 20g of gelatin and 10g of carboxymethyl chitosan into a beaker, add 400mL of deionized water and stir mechanically for 1 hour. After stirring evenly, heat up to 35°C. Add 3g of AFGF freeze-dried powder at this temperature and continue to stir and mix. 1h, get the transparent liquid loaded with AFGF; then weigh 20g sodium carboxymethyl cellulose, 5g apple pectin, 5g snail mucus and 10g sodium alginate into 400mL deionized water, stir and mix with the transparent liquid loaded with AFGF After mixing, use an ultrasonic oscillator to ultrasonically oscillate at a power of 220W for 10 minutes, heat to 55°C after oscillating, add 3mL of 1% glutaraldehyde solution and 1mL of 0.1% hydrochloric acid solution at this temperature, and keep the reaction for 3h. After stirring, the reaction solution was obtained; then weighed 100g of styrene-isoprene block copolymer into the reaction kettle, heated to 140°C, stirred until it melted, added 20g of terpene resin after meltin...

example 2

[0026]First weigh 25g of gelatin and 13g of carboxymethyl chitosan into a beaker, add 450mL of deionized water and stir mechanically for 1 hour, stir evenly and then heat up to 36°C, add 4g of AFGF freeze-dried powder at this temperature, and continue to stir and mix 1h, get the transparent liquid loaded with AFGF; then weigh 25g sodium carboxymethyl cellulose, 8g apple pectin, 8g snail mucus and 13g sodium alginate into 450mL deionized water, stir and mix with the transparent liquid loaded with AFGF After mixing, use an ultrasonic oscillator to ultrasonically oscillate at a power of 235W for 13 minutes, heat to 60°C after oscillating, add 4mL of 1% glutaraldehyde solution and 2mL of 0.1% hydrochloric acid solution at this temperature, and keep the reaction for 4h. After stirring, the reaction solution was obtained; then weighed 110g of styrene-isoprene block copolymer into the reaction kettle, heated to 150°C, stirred until it melted, added 30g of terpene resin after melting, ...

example 3

[0029] First weigh 30g of gelatin and 15g of carboxymethyl chitosan into a beaker, add 500mL of deionized water and stir mechanically for 2 hours, stir evenly and then heat up to 37°C, add 5g of AFGF freeze-dried powder at this temperature, and continue to stir and mix 2h, get the transparent liquid loaded with AFGF; then weigh 30g sodium carboxymethyl cellulose, 10g apple pectin, 10g snail mucus and 15g sodium alginate into 500mL deionized water, stir and mix with the transparent liquid loaded with AFGF After mixing, use an ultrasonic oscillator to ultrasonically oscillate at a power of 250W for 15 minutes, heat to 65°C after oscillating, add 5mL of 1% glutaraldehyde solution and 3mL of 0.1% hydrochloric acid solution at this temperature, and keep the reaction for 5h. After stirring, the reaction liquid was obtained; then weighed 120g of styrene-isoprene block copolymer into the reaction kettle, heated to 160°C, stirred until it melted, added 40g of terpene resin after melting...

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Abstract

The invention discloses a preparation method for hydrocolloid dressing for promoting wound repairing, belonging to the technical field of medical dressing preparation. The method comprises the following steps: adding AFGF freeze-dried powder into a mixed solution of gelatin and carboxymethyl chitosan, thereby acquiring an AFGF-loaded transparent fluid; mixing with dissolving fluid of the matters including sodium carboxymethylcellulose, apple pectin, and the like; ultrasonically oscillating and then adding a cross-linking agent; performing cross-linking reaction under a certain temperature, acquiring reaction fluid and then mixing with resin viscous fluid, thereby acquiring a spinning solution; spinning by adopting a wet method, thereby acquiring an AFGF-loaded fiber; mixing with a pure cotton fiber and spinning to form cloth. According to the preparation method, the apple pectin is added, so that the water absorption lasting time of the dressing is increased and the gelling is quickened; styrene-isoprene segmented copolymer is added, so that the dressing viscidity and the peeling strength are effectively improved; hydrocolloid is prepared into weaved cloth and no film substrate is required, so that the problem of weak binding force between hydrocolloid and polymer film is solved and the wound repairing can be effectively promoted; the preparation method has wide application prospect.

Description

technical field [0001] The invention discloses a preparation method of a hydrocolloid dressing for promoting wound repair, and belongs to the technical field of preparation of medical dressings. Background technique [0002] Human skin can not only stabilize the internal environment of the human body, but also prevent the invasion of bacteria and microorganisms. When the skin is injured and the homeostasis of the internal environment is broken, medical dressings, as a medical wound healing material, can provide the necessary protection to the human body and reduce the degree of harm. Before the skin recovers, a good medical dressing can temporarily play a part of the skin covering function and provide favorable conditions for wound healing. [0003] Medical hydrocolloid dressing is a medical material made by mixing hydrocolloid particles with rubber substrate. This material combines the water-absorbing properties of hydrocolloid particles with the adhesive properties of ru...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00A61L15/44A61L15/40A61L15/22
CPCA61L15/225A61L15/40A61L15/44A61L26/0052A61L26/0057A61L26/0066A61L26/008A61L2300/414
Inventor 周丽花徐越薛蕾
Owner 青岛华元精细生物制品有限公司
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