Preparing method of elastic degradable biomedical material

A technology for biomedical materials and degradable polymers, applied in the field of biomedical material preparation, can solve the problems of large elastic deformation, poor controllability of degradation rate, limited application, poor strength and extensibility, affecting wound healing and tissue repair, etc. The effect of controllable degradation rate, good breaking strength and elasticity

Inactive Publication Date: 2017-01-11
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] International patent WO2006 / 100895 discloses a medical film composed of lactide and caprolactone copolymer, which has good flexibility and strength, but the degradation rate of the material itself is relatively slow, and it takes 6 months for complete absorption, which may affect the wound Healing and tissue repair function
The publication number is CN104650369A Chinese patent application discloses a method for preparing a gelatin nanofiber membrane. The gelatin nanofiber membrane has good degradation performance and can be completely degraded within 40 days, but its strength and stretchability are poor
The publication number is CN105396181A. The Chinese patent application discloses a preparation method of a degradable stent medical film. The medical film is made of polylactic acid polymer material through electrospinning. Due to the limited elasticity of the material itself, the medical film cannot withstand Large elastic deformation and poor controllability of degradation rate limit its application in biomedical materials

Method used

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  • Preparing method of elastic degradable biomedical material
  • Preparing method of elastic degradable biomedical material
  • Preparing method of elastic degradable biomedical material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A method for preparing an elastic degradable biomedical material, the specific steps are:

[0029] (1) Synthesis of POC (poly-1,8-octanediol-citrate) elastomer by melt condensation polymerization of 1,8-octanediol and citric acid: 1,8-octanediol and citric acid molar Weigh it at a ratio of 1:1, put it into a three-necked round bottom flask, and stir it in an oil bath under normal pressure and a temperature of 160-165°C for 15 minutes to make the reaction monomer 1,8-octanediol and citric acid Melt completely, and then drop the temperature to 140-145°C for 40-60 minutes to melt and polycondense until the magnetic stirring is difficult (close to the gel point) to obtain POC, and then dissolve the POC in 50ml of absolute ethanol and deionize Precipitate in water (remove unreacted monomer by dissolving), then collect POC and vacuum freeze-dry for 24 hours to obtain purified POC.

[0030] (2) Weigh 0.36g POC and 0.54g PLA (POC / PLA: 40 / 60) with ME104E Mettler-Torley electron...

Embodiment 2

[0035] A method for preparing an elastic degradable biomedical material, the specific steps are:

[0036] (1) is the same as step (1) in Example 1.

[0037] (2) Weigh 0.225g POC and 0.675g PLA (POC / PLA: 25 / 75) with ME104E Mettler-Torley electronic balance, mix and dissolve in 10ml of hexafluoroisopropanol solvent, make it fully stirred until Dissolve completely, obtain the POC / PLA mixed spinning solution that the total concentration of POC and PLA is 9% (g / ml);

[0038] (3) Use electrospinning equipment for electrospinning, such as figure 1As shown, the electrospinning equipment includes a syringe 1 (plastic syringe) with a capacity of 10ml, a high-voltage power supply 5 and a receiving device 6. The bottom end of the syringe 1 is provided with a 21G flat needle 3, and the flat needle 3 is located on the receiving device. Above the device 6, the positive pole of the high voltage power supply 5 is connected to the flat needle 3, and the negative pole is grounded. The voltage ...

Embodiment 3

[0042] A method for preparing an elastic degradable biomedical material, the specific steps are:

[0043] (1) is the same as step (1) in Example 1.

[0044] (2) Weigh 0.09g POC and 0.81g PLA (POC / PLA: 10 / 90) with ME104E Mettler-Torley electronic balance, mix and dissolve them in 10ml of hexafluoroisopropanol solvent, and stir them thoroughly until Dissolve completely, obtain the POC / PLA mixed spinning solution that the total concentration of POC and PLA is 9% (g / ml);

[0045] (3) Use electrospinning equipment for electrospinning, such as figure 1 As shown, the electrospinning equipment includes a syringe 1 (plastic syringe) with a capacity of 10ml, a high-voltage power supply 5 and a receiving device 6. The bottom end of the syringe 1 is provided with a 21G flat needle 3, and the flat needle 3 is located on the receiving device. Above the device 6, the positive pole of the high voltage power supply 5 is connected to the flat needle 3, and the negative pole is grounded. The v...

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Abstract

The invention provides a preparing method of an elastic degradable biomedical material. The method is characterized by comprising the steps of synthesizing POC elastomer through melt phase polycondensation of octamethylene glycol and citric acid, mixing POC elastomer and biological degradable polymer, and dissolving in solvent to obtain spinning solution, conducting electrostatic spinning with an electrostatic spinning device, and preparing the elastic degradable biomedical material. The elastic degradable biomedical material has the advantages of no toxicity, controllable degradation rate, good breaking strength, elasticity and the like.

Description

technical field [0001] The invention belongs to the field of preparation of biomedical materials, in particular to a preparation method of elastic degradable biomedical materials. Background technique [0002] Tissue engineering is an emerging science that applies the principles of cell biology and engineering to research and develop biological substitutes that can repair and improve damaged tissue functions. The emergence and development of tissue engineering provides a new and effective method for tissue defect repair and tissue regeneration. Tissue cells, scaffolds and growth factors are the three major elements of tissue engineering, and scaffold materials play a central role in tissue engineering. [0003] The methods for preparing nanofibrous scaffolds include self-assembly, phase separation, and electrospinning. Among them, the electrospinning technology has high specific surface area and porosity due to the high specific surface area and porosity of the spun nanofib...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/26A61L27/58C08G63/12D01F8/14
CPCA61L27/26A61L27/58A61L2400/16C08G63/12D01F8/14C08L67/04C08L5/08
Inventor 王新厚邹方东
Owner DONGHUA UNIV
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