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Applications of ozonized oil in treatment of nerve injuries

A technique for ozonating oil and nerve damage, applied in the field of medicine, can solve problems such as unclear specific mechanism and difficulty in ensuring the effective concentration of gas entering the body

Inactive Publication Date: 2017-01-25
侯建生
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The function of ozone gas may be realized through the following three ways: (1), ozone generates substances similar to active oxygen through biochemical reactions in the body (hydroxyl radical OH - , superoxide anion O 2 - etc.), extensively affects the redox system of the body; (2), ozone can cause the aggregation of endothelial progenitor cells and promote the generation of nitric oxide (NO), which can relax blood vessels; (3), ozone can induce bone marrow stem cells to At the site of vascular injury, it promotes the repair and reconstruction of damaged blood vessels, but the specific mechanism is still unclear
[0003] There are many defects in the above route of administration: contact with too many substances along the way, it is difficult to ensure the effective concentration of gas entering the body
However, the form of enteric-coated capsules made of ozonated oil enters the body through direct oral administration to produce efficacy, and there is no report yet

Method used

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  • Applications of ozonized oil in treatment of nerve injuries
  • Applications of ozonized oil in treatment of nerve injuries

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1 Preparation of ozonated olive oil enteric-coated capsules

[0017] 1. Preparation of ozone gas. The invention adopts medical oxygen to prepare ozone gas through an ozone generator.

[0018] It is selected from the DRO3-A ozone machine (power≦55W) designed and produced by Xi'an Derun Biotechnology Co., Ltd.

[0019] 2. The whole process of preparing ozonated oil and ozonated oil enteric-coated capsules must be carried out at 20-25°C to ensure that the ozonated oil does not undergo pyrolysis.

[0020] 3. Put 3kg of olive oil into the reactor; 3 / h flow rate was added, and the total reaction time was 20 hours. After the reaction is over, the residual gas is inactivated.

[0021] 4. The obtained ozonated olive oil has a concentration of 40 mg / L and can be stored stably for ten months at 25°C.

[0022] 5. Preparation of ozonated olive oil enteric-coated capsules.

[0023] (1) Preparation of capsule material: Weigh water, gelatin, glycerin and glutinous rice f...

Embodiment 2

[0026] Preparation of enteric-coated capsules of embodiment 2 ozonated olive oil, soybean oil and peanut oil mixed oil

[0027] 1. Preparation of ozone gas. The invention adopts medical oxygen to prepare ozone gas through an ozone generator.

[0028] It is selected from the DRO3-A ozone machine (power≦55W) designed and produced by Xi'an Derun Biotechnology Co., Ltd.

[0029] 2. The whole process of preparing ozonated oil and ozonated oil enteric-coated capsules must be carried out at 20-25°C to ensure that the ozonated oil does not undergo pyrolysis.

[0030] 3. Put 1kg of olive oil, 1kg of soybean oil and 1kg of peanut oil into the reaction kettle; 3 / h flow rate was added, and the total reaction time was 20 hours. After the reaction is over, the residual gas is inactivated.

[0031] 4. The concentration of the obtained ozonated mixed oil is 40mg / L, and it can be stored stably for ten months at 25°C.

[0032] 5. Preparation of ozonated mixed oil enteric-coated capsules. ...

Embodiment 3

[0035] Capsules were made at room temperature at 22°C, the rubber thickness was 0.7mm, and the capacity was 0.25mL. The soft capsules were cooled in a tumbler for 8 hours, taken out of the cage, and dried to obtain ozonated mixed oil enteric-coated capsules, which were stored at 4°C in the dark for later use. . Example 3 Preparation of ozonated olive oil enteric-coated capsules containing surfactant

[0036] 1. Preparation of ozone gas. The invention adopts medical oxygen to prepare ozone gas through an ozone generator.

[0037] It is selected from the DRO3-A ozone machine (power≦55W) designed and produced by Xi'an Derun Biotechnology Co., Ltd.

[0038] 2. The whole process of preparing ozonated oil and ozonated oil enteric-coated capsules must be carried out at 20-25°C to ensure that the ozonated oil does not undergo pyrolysis.

[0039] 3. Put 3kg of olive oil into the reaction kettle, slowly add 20mL of sorbitan monooleate polyoxyethylene ether (Tween 80), mix well, and use...

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Abstract

The present invention relates to the application in nerve injury and drug combination with the drug for treating nerve injury, administered through the oral route and administered by intraperitoneal injection, enema, gavage, intravenous injection, subcutaneous injection, intramuscular injection and suppository It can effectively prevent and treat various nerve injuries, mainly including optic nerve, spinal nerve injury, oculomotor nerve injury and other cranial nerve injuries.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the use of ozonated oil in the treatment of nerve damage and the combined use of medicines for treating nerve damage. Background technique [0002] Velio Bocci in the book "Ozone Therapy" outlines the use of low doses of ozone gas to perform many beneficial functions without side effects, namely ozone therapy (see "Oxygen-Ozone Therapy" by Velio Bocci, Peking University Medical Press , 2004). Ozone therapy can be achieved through a variety of routes of administration, and produce different effects for different diseases. Ozonated oil is used externally as an antibacterial agent, deodorant and in the treatment of skin diseases such as bedsores and ulcers. Therefore, ozone is known to have oxidizing and antibacterial effects. The ozonated oil was directly administered into the stomach for the treatment of gastritis caused by Helicobacter pylori. Intramuscular or su...

Claims

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Application Information

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IPC IPC(8): A61K33/00A61K9/66A61K47/44A61P25/00A61P27/02A61P19/08
CPCA61K33/00A61K9/0019A61K9/0053A61K9/4808A61K9/4816A61K9/4858A61K47/44
Inventor 李新平侯建生
Owner 侯建生
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