Degradable composite material and contraceptive ring with the same and preparing method thereof

A composite material and birth control ring technology, which is applied in the field of suitable materials and preparations for birth control rings to prevent intrauterine adhesions, can solve problems such as allergic reactions, uterine cavity tissue coating, inflammation, etc., and achieve easy production and preparation and tissue compatibility Good, the effect of preventing inflammation

Active Publication Date: 2017-02-01
THE SECOND HOSPITAL AFFILIATED TO SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the materials of the birth control ring clinically used in the uterine cavity mainly include metal copper, etc., because the metal copper cannot be degraded, so when the birth control ring made of it is in the uterine cavity for a period of time, after the function of human tissue recovers, it must pass through. Second surgery to remove, because long-term existence in the body often easily causes seroma, foreign body reaction, etc.
The second operation will increase the pain of the patient and the burden of medical expenses. At the same time, if the birth control ring made of this material is too long in the human uterine cavity, it is easy to cover the uterine cavity. Great difficulty, the patient's pain will be greatly increased, the therapeutic effect will be greatly reduced, and it is more likely to cause local allergic reactions or inflammation

Method used

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  • Degradable composite material and contraceptive ring with the same and preparing method thereof
  • Degradable composite material and contraceptive ring with the same and preparing method thereof
  • Degradable composite material and contraceptive ring with the same and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) under the protection of inert gas, the polydioxanone of 60 weight parts, the polycaprolactone of 20 weight parts, the polylactic acid (PLLA) of 20 weight parts, the chitosan of 10 weight parts, 10 parts by weight of starch, 10 parts by weight of polyethylene glycol, 20 parts by weight of polylactic-glycolic acid (PLGA), 10 parts by weight of hydroxyapatite, and 10 parts by weight of magnesium powder are added to the reactor, and the Stirring device to ensure that the materials in the reactor are mixed evenly; the intrinsic viscosity of polylactic acid is 5.

[0031] (2) Turn on the heating device, the heating rate of the first section is 2.5°C / h to 90°C, and the stirring speed is 180rpm; the second section's heating rate is 8°C / h to 120°C, and the stirring speed is 120rpm; the third section The heating rate is 20°C / h to 200°C, and the stirring speed is 80rpm; the fourth constant temperature reaction section, the reaction temperature is 200°C, the reaction time is 12...

Embodiment 2

[0040] (1) under the protection of inert gas, the polydioxanone of 50 weight parts, the polycaprolactone of 30 weight parts, the polylactic acid (PLLA) of 30 weight parts, the chitosan of 20 weight parts, The starch of 15 parts by weight, the polyethylene glycol of 15 parts by weight, the polylactic acid-glycolic acid (PLGA) of 15 parts by weight, the hydroxyapatite of 15 parts by weight, the magnesium powder of 15 parts by weight are added in the reactor, open Stirring device to ensure that the materials in the reactor are mixed evenly; the intrinsic viscosity of polylactic acid is 5.

[0041] (2) Turn on the heating device, the heating rate of the first stage is 5°C / h to 100°C, the stirring speed is 250rpm; the second stage is 10°C / h to 120°C, and the stirring speed is 200rpm; the third stage The heating rate is 20°C / h to 240°C, and the stirring speed is 120rpm; the fourth constant temperature reaction section, the reaction temperature is 240°C, the reaction time is 12h, the...

Embodiment 3

[0050] (1) under the protection of inert gas, the polydioxanone of 30 weight parts, the polycaprolactone of 25 weight parts, the polylactic acid (PLLA) of 25 weight parts, the chitosan of 15 weight parts, 20 parts by weight of starch, 30 parts by weight of polyethylene glycol, 30 parts by weight of polylactic-glycolic acid (PLGA), 15 parts by weight of hydroxyapatite, and 20 parts by weight of magnesium powder are added to the reactor and opened Stirring device to ensure that the materials in the reactor are mixed evenly; the intrinsic viscosity of polylactic acid is 5.

[0051] (2) Turn on the heating device, the heating rate of the first section is 10°C / h to 100°C, and the stirring speed is 250rpm; the second section's heating rate is 15°C / h to 130°C, and the stirring speed is 200rpm; the third section The heating rate is 40°C / h to 260°C, and the stirring speed is 120rpm; the fourth constant temperature reaction section, the reaction temperature is 260°C, the reaction time i...

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PUM

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Abstract

The invention discloses a degradable composite material and a contraceptive ring with the same and a preparing method thereof. The degradable composite material is prepared from poly p-dioxanone, polycaprolactone, polylactic acid, chitosan, starch, polyethylene glycol, polylactic acid-glycolic acid, hydroxyapatite, magnesium powder and the like; the contraceptive ring prepared with the method can be degraded and absorbed in vivo, is good in tissue compatibility, and cannot be taken out through an operation again, and generation of inflammation is effectively prevented. Meanwhile, the contraceptive ring has the enough mechanical strength, and the mechanical requirements required by supporting the uterus cavity can be met. In addition, the contraceptive ring is easy to produce, prepare and mold, and the contraceptive rings with the different shapes can be made.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a degradable contraceptive ring material for preventing intrauterine adhesions and a preparation method thereof. Background technique [0002] In recent years, with the continuous development of endoscopic instruments, minimally invasive endoscopic surgery has also been fully developed. This type of surgery has been widely used in many departments such as thoracic surgery, general surgery, obstetrics and gynecology, and urology. Minimally invasive laparoscopic surgery has the advantages of less trauma, less pain, less bleeding, and shorter hospital stay, so it is not only highly praised by doctors but also recognized by patients. [0003] In recent years, surgical internal fixation of the contraceptive ring has a good effect in the treatment of intrauterine adhesions. At present, the materials of the birth control ring clinically used in the uterine cavity mainly include meta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L67/04C08L5/08C08L3/02C08L71/02C08K3/32C08K3/08A61L31/14A61L31/06A61L31/04A61L31/02
CPCA61L31/022A61L31/028A61L31/042A61L31/06A61L31/14A61L31/148C08K2201/011C08L67/04C08L2201/06C08L2205/025C08L2205/035C08L5/08C08L3/02C08L71/02C08K2003/325C08K3/08
Inventor 朱维培刘利芬
Owner THE SECOND HOSPITAL AFFILIATED TO SUZHOU UNIV
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