Method for preparing mesoporous hydroxyapatite through combining microwave and gaseous diffusion

A technology of mesoporous hydroxyapatite and hydroxyapatite, which is applied in the field of materials science, can solve the problems of increasing process complexity and production cost, polluting the purity of mesoporous hydroxyapatite, environmental pollution, etc., and achieves product appearance. Controllable, environmentally friendly and low-cost effects

Active Publication Date: 2017-02-15
CHANGZHOU UNIV
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

However, the raw materials used in the template method or emulsification method may have certain toxicity, and their residues will pollute the purity of mesoporous hydroxyapatite, and may cause particle agglomeration during high-temperature calcination.
These all increase the complexity and production cost of the process, and may cause environmental pollution

Method used

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  • Method for preparing mesoporous hydroxyapatite through combining microwave and gaseous diffusion
  • Method for preparing mesoporous hydroxyapatite through combining microwave and gaseous diffusion
  • Method for preparing mesoporous hydroxyapatite through combining microwave and gaseous diffusion

Examples

Experimental program
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Effect test

Embodiment 1

[0029] Using 0.147 g of calcium chloride as the calcium source and 0.142 g of disodium hydrogen phosphate as the phosphorus source, prepare a 200 mL reaction solution with a calcium-to-phosphorus ratio of 1, and use dilute hydrochloric acid to adjust the pH to 4. A cup of 200 mL of concentrated ammonia water diluted five times was placed in the microwave reaction device at the same time as the source of ammonia gas. Use 300W microwave to heat for 5 minutes. After the reaction, the product was collected by filtration, washed with water, and air-dried at 60 °C to obtain a hydroxyapatite with a mesoporous structure ( figure 1 ).

Embodiment 2

[0031] 0.147 g of calcium chloride was used as the calcium source, and 0.071 g of disodium hydrogen phosphate was used as the phosphorus source to prepare a 200-mL reaction solution with a calcium-to-phosphorus ratio of 2, and dilute hydrochloric acid was used to adjust the pH to 4.5. During the microwave reaction process, ammonia gas is directly introduced into the microwave reaction device. Use 400W microwave to heat for 4 minutes. After the reaction, the product was collected by filtration, washed with water, and air-dried at 80°C to obtain a hydroxyapatite with a mesoporous structure ( figure 2 ).

Embodiment 3

[0033] Using 0.086 g calcium gluconate as the calcium source and 0.016 g sodium dihydrogen phosphate as the phosphorus source, prepare a 100 mL reaction solution with a calcium to phosphorus ratio of 1.5, and use dilute nitric acid to adjust the pH to 4. A cup of 200 mL of concentrated ammonia water diluted ten times was placed in the microwave reaction device at the same time as the source of ammonia gas. Use 300W microwave to heat for 6 minutes, filter and collect the product after the reaction, wash with water, and air-dry at 60 °C to obtain hydroxyapatite with a mesoporous structure ( image 3 ).

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Abstract

The invention relates to a method for preparing mesoporous hydroxyapatite nanoparticles through combining microwave and gaseous diffusion. The method comprises the following steps: firstly, adding soluble calcium salt and soluble phosphate into water to form a mixed solution, and adjusting the pH of the mixed solution to be acidic with an acid; then transferring the acidic solution into a microwave reactor, carrying out microwave heating, diffusing ammonia gas to the reaction solution in the heating process, and then participating in a reaction; and finally, collecting a precipitate, namely the hydroxyapatite nanoparticles with a mesoporous structure. The method is green and economical, the used raw materials are all common chemical raw materials, and emulsifiers or template agents are not needed to be added during synthesis of the mesoporous hydroxylapatite nanoparticles. The obtained mesoporous hydroxylapatite nanoparticles have relatively high specific surface area, and can be used as an ideal adsorption material.

Description

technical field [0001] The invention belongs to the field of materials science, and more particularly, the invention relates to a novel method for preparing mesoporous hydroxyapatite nanoparticles by combining microwave and gas-phase diffusion. Background technique [0002] Hydroxyapatite (Hydroxyapatite, referred to as HA), its chemical formula is Ca 10 (PO 4 ) 6 (OH) 2 , is the main inorganic component of bones and teeth in vertebrates. It has good biocompatibility, bioactivity and osteoconductive properties. After it is implanted into the body, the hydroxyapatite will be gradually absorbed by the body tissue, chemically combined with the human bone tissue, and finally partially or completely absorbed and replaced by the body tissue. Therefore, hydroxyapatite is an ideal bioceramic material, which is widely used in tissue engineering, bone defect filling, drug delivery, gene transfection, blood purification and other fields. In addition, since calcium ions in hydroxy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32B82Y40/00
CPCC01B25/32C01P2004/04C01P2004/64C01P2006/12C01P2006/16
Inventor 周欢侯赛赛杨蒙蒙邓林红
Owner CHANGZHOU UNIV
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