Comprehensive extraction and utilization production technology for propolis

A technology of comprehensive extraction and production process, which is applied in the field of production process of comprehensive extraction and utilization of propolis, can solve the problems such as the reduction of the extraction rate of propolis extract, and achieve the effect of low equipment requirements, simple steps, and simplified preparation steps

Active Publication Date: 2017-04-05
NANJING XIYUAN BIOPHARML SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the process of supercritical CO2 fluid extraction, extraction pressure and temperature, separation pressure and temperature, fluid flow and extraction time, type and amount of entrainer are important factors that affect the extraction rate and biological ac

Method used

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  • Comprehensive extraction and utilization production technology for propolis
  • Comprehensive extraction and utilization production technology for propolis
  • Comprehensive extraction and utilization production technology for propolis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1 Preparation of propolis net glue

[0044] A preparation process of propolis net glue includes the following steps:

[0045] 1) Pretreatment: Collect 165kg of Brazilian green propolis gel and perform pre-cooling treatment, the pre-cooling temperature is -10 ℃, the pre-cooling time is 12 hours, and then pulverize to obtain propolis particles;

[0046] 2) Mixing: Mix the pretreated propolis particles and rice husk in a weight ratio of 1:4 to obtain a mixture;

[0047] 3) Non-critical fluid extraction: add n-butane to the mixture for extraction in the extraction tank, the extraction pressure is 6MPa, the temperature is 40°C, and the stirring speed is 30rpm; stand for 60min to obtain the n-butane extract;

[0048] 4) Solid-liquid separation: the n-butane extract is transferred to the evaporation tank for evaporation, and the propolis net glue and rice husk with propolis net glue are left in the extraction tank;

[0049] 5) Screening: Sieve the net propolis and the rice husk w...

Embodiment 4

[0062] Example 4 Preparation of freeze-dried propolis powder

[0063] 1) Soaking: The rice husk with propolis gel obtained in step 5) of Example 1 was added with 95% food grade ethanol at a solid-to-liquid ratio of 1:5 while stirring, soaking for 12 hours at a stirring speed of 40 rpm to obtain a solid Liquid mixture

[0064] 2) Solid-liquid separation: The solid-liquid mixture is sieved with an 80-mesh sieve, the rice husks are removed and collected, and the supernatant is left in the extraction tank and allowed to stand for 4-6 hours. The supernatant is heated to obtain a semi-fluid leaching 75kg of paste and recovery of food grade ethanol at the same time; heating temperature is 50℃; pressure in extraction tank is -0.1MPa;

[0065] 3) Freeze-drying: vacuum freeze-drying the semi-fluid extract to obtain freeze-dried propolis powder particles, which are divided into three stages: pre-cooling treatment, freezing treatment, and heating treatment; the pre-cooling temperature is -18°C,...

Embodiment 5

[0067] Example 5 Preparation of propolis lyophilized powder

[0068] 1) Soaking: The rice husk with propolis gel obtained in step 5) of Example 2 was added with 95% food grade ethanol at a solid-to-liquid ratio of 1:8 while stirring, soaking for 16 hours, and stirring at 30 rpm to obtain a solid Liquid mixture

[0069] 2) Solid-liquid separation: The solid-liquid mixture is sieved with an 80-mesh sieve, the rice husks are removed and collected, and the supernatant is left in the extraction tank and allowed to stand for 4-6 hours. The supernatant is heated to obtain a semi-fluid leaching 69kg of paste and recovery of edible ethanol at the same time; heating temperature is 55℃; pressure in extraction tank is -0.9MPa.

[0070] 3) Freeze-drying: vacuum freeze-drying the semi-fluid extract to obtain freeze-dried propolis powder particles, which are divided into three stages: pre-cooling treatment, freezing treatment, and heating treatment; the pre-cooling temperature is -20°C, overnight ...

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Abstract

The invention discloses a comprehensive extraction and utilization production technology for propolis. The method comprises the following steps: 1) pretreatment; 2) mixing; 3) non critical fluid extraction; 4) removal of n-butane through ultimate vacuum; 5) addition of a weak solution for mixing; 6) removal of n-butane through ultimate vacuum; 7) de-waxing; and 8) solid-liquid separation. The invention employs an extraction technology by taking low-temperature non critical fluid n-butane as a solvent, Brazilian A-grade propolis is taken as a raw material, and the propolis particles can be prepared by steps of selection, refrigeration at the temperature of -10 DEG C, crushing, blending with rice husk, extraction by employing non-critical fluid, screening, freeze drying, crushing and package, and propolis premix liquid is prepared by the steps of desolvation through ultimate vacuum, addition of a diluents, de-waxing, filtering and package. propolis yield is 30-35%, the general flavone content is 22-25%, the general flavone content in propolis freeze-drying powder is 22-25%, and the lead content is 0.48-0.50 mg/kg.

Description

Technical field [0001] The invention belongs to the technical field of health food production and processing, and specifically relates to a production process for comprehensive extraction and utilization of propolis. Background technique [0002] Propolis is the resinous substance secreted by the young buds and callus of poplar, willow and other plants by the worker bees of honeybees and the secretions of their own digestive glands and wax glands (such as beeswax and various digestive enzymes) A viscous natural mixture formed after mixing. Propolis is an effective substance used by bees to maintain the health of the entire colony. A colony of 50,000 to 60,000 bees can only produce 100 to 150g of propolis a year, so it is known as "purple gold." Propolis is mostly blue-brown, yellow-brown or dark brown, and is a solid sticky substance. It tastes bitter, irritating, burns with resin aroma, is viscous and plastic at 35-45°C, soluble in viscous fluid at 65°C, dissolves at 100°C, an...

Claims

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Application Information

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IPC IPC(8): A23L21/20A23L33/10A61K35/644A61K8/98A61K8/92A61Q19/08A61P39/06A61P35/00A61P29/00A61P37/02B01D11/02
CPCA61K8/927A61K8/988A61K35/644A61Q19/08B01D11/02
Inventor 刘勇业马青青韩汀
Owner NANJING XIYUAN BIOPHARML SCI & TECH
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