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Bulleyaconitine A liniment, preparation method, and applications thereof

The technology of clathrin and formula, applied in the field of medicine, can solve problems such as difficulty in swallowing of the elderly, inconvenient use of patients, and large dosage, and achieve the effects of reducing systemic side effects, fast onset of action, and fast drug absorption.

Inactive Publication Date: 2017-04-05
KPC PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the oral dosage form has great limitations for the treatment of local inflammation and pain such as local arthritis, such as its slow onset of action, large dosage, and the tablet is difficult for the elderly to swallow, which brings inconvenience to the use of patients
[0006] In addition, at present, there have been research and development of transdermal preparations such as aconitin patch, but because aconitin has a strong stimulating effect, it is easy to cause allergies to users
Therefore, there is no safe and effective external preparation of aconitin for clinical application.

Method used

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  • Bulleyaconitine A liniment, preparation method, and applications thereof
  • Bulleyaconitine A liniment, preparation method, and applications thereof

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preparation example Construction

[0022] The preparation method of aconitin liniment of the present invention comprises the following steps:

[0023] A, the aconitin is ground and sieved for subsequent use;

[0024] B. Add azone and glycerol triacetate in proportion to the propylene glycol successively, and mix to obtain a mixed solvent;

[0025] C. Add the mixed solvent obtained in the step B to the aconitin treated in the step A of the formula ratio, and ultrasonically vibrate to obtain the target aconitin liniment.

[0026] The grinding and sieving described in the A step is to pass through a 60-80 mesh sieve.

[0027] The frequency of the ultrasonic oscillation described in step C is 40KHz, and the time is 5-10min.

[0028] The application of the aconitin liniment of the present invention is the application of the aconitin liniment in the preparation of medicines for treating inflammation and / or pain.

[0029] Described inflammation and / or pain are selected from rheumatism and rheumatoid arthritis, froz...

Embodiment 1

[0031] Example 1 Preparation of Aconitin Liniment 1

[0032] Prescription: Aconitine: 4 g

[0033] Propylene glycol: 220ml

[0034] Azone: 25ml

[0035] Triacetin: 7751 ml

[0036] Preparation:

[0037] 1. Grind through an 80-mesh sieve, weigh 4 g of aconitin, and set aside;

[0038] 2. Measure 220 ml of propylene glycol, put it in a 1000 ml volumetric flask, add 25 ml of azone, and then add glycerol triacetate to the mark, and make a clear compound solvent for later use;

[0039] 3. Add the ground aconitin into another 1000 ml volumetric flask, and gradually add 800 ml of the composite solvent prepared in the above step 2, and dissolve the aconitin under the condition of ultrasonic oscillation, and the solution is clear , after standing, add the above-mentioned mixed solvent to 1000 ml to obtain the Aconitin liniment 1 of the present invention.

Embodiment 2

[0040] Example 2 Preparation of Aconitin Liniment 2

[0041] Prescription: Aconitine: 1 g

[0042] Propylene glycol: 230ml

[0043] Azone: 20 ml

[0044] Triacetin: 749 ml

[0045] Preparation:

[0046] 1. Weigh 1g of aconitin, grind it through an 80-mesh sieve for later use;

[0047] 2. Measure 230ml of propylene glycol, put it in a 1000ml volumetric flask, add 20ml of azone, then add glycerol triacetate to the mark, and make a clear mixed solvent for later use;

[0048] 3. Add the ground aconitin into another 1000ml volumetric flask, and gradually add 800ml of the mixed solvent prepared in the above step 2. Under the condition of ultrasonic oscillation, the aconitin is dissolved, the solution is clear, and placed Add above-mentioned mixed solvent again to 1000ml, obtain the aconitin liniment 2 of the present invention.

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Abstract

The invention discloses a bulleyaconitine A liniment, a preparation method, and an applications thereof. The bulleyaconitine A liniment is composed of, by mass, 0.1-1.0% of bulleyaconitine A, 4-25% of propylene glycol, 0.2-2.5% of azone, and 74-95% of glycerol triacetate. The preparation method includes the steps of: grinding and sieving the bulleyaconitine A for later use; adding the azone and the glycerol triacetate to the propylene glycol according to the ratio in the formula, and uniformly mixing the components to obtain a mixed solvent; adding the mixed solvent to the bulleyaconitine A, and performing ultrasonic vibration to obtain the target product, bulleyaconitine A liniment. The bulleyaconitine A liniment is applied in preparation of drugs for therapy of inflammation and / or pain. The novel bulleyaconitine A liniment is researched through deeply researching studies of the inventor, wherein the optimum-selected solvent composition satisfies the solvent permeation-assisting system, so that the liniment is quick to absorb and has no irritation and allergy on skin.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an aconitin liniment and a preparation method and application thereof. Background technique [0002] Aconitin is a diterpene alkaloid extracted from Aconitum aconitum, a plant of the genus Aconitum, Ranunculaceae in Yunnan. It has strong analgesic effect and anti-inflammatory effect. Its analgesic effect is central, and it has not been found to be addictive. [0003] Aconitin is mainly used for advanced cancer pain, rheumatism and rheumatoid arthritis, frozen shoulder, shoulder and arm pain, stiff neck, osteoarthritis, benign joint pain, waist and limb joint sprains, contusions, lumbar muscle strain and low back pain , sciatica, myofibritis and costochondritis, herpes zoster, cold headache, toothache, etc. [0004] At present, the most commonly used dosage form is the Aconitin Tablets, which can be used to treat rheumatism and rheumatoid arthritis, lumbar muscle st...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/439A61K47/22A61K47/14A61K47/10A61P25/04A61P29/00
Inventor 高永良张伟杨兆祥
Owner KPC PHARM INC
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