A menthol-camphor eutectic nanoemulsion in situ gel preparation
An in-situ gel, eutectic technology, applied in the directions of drug combination, aerosol delivery, emulsion delivery, etc., can solve the problem of transmucosal absorption of menthol and camphor, no oil phase nanoemulsion preparation in situ coagulation. Glue, affecting the stability of active ingredients or preparations, etc., to achieve good mucosal penetration promotion function, conducive to absorption through nasal mucosa, and improve the effect of drug absorption
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Embodiment 1
[0050] Weigh 2.00 g eutectic product as the oil phase, add 4.00 g Tween-80 and 2.00 g glycerin and mix well; gradually add 20 mL water into the above mixture and mix well to make a nanoemulsion; add 0.50 g deacetylated Add cold gelatin to 50 mL of deionized water, and then add 0.20 g of sodium alginate to make a gel solution; add nanoemulsion to the gel solution, mix well, and add water to 100 mL. The measured nanoemulsion in the above system is recorded as sample 1, and the specific parameters are shown in Table 1.
Embodiment 2
[0052] Weigh 1.00 g of eutectic product as the oil phase, add 5.00 g of polyethylene glycol octylphenyl ether and 5.00 g of propylene glycol and mix well; gradually add 20 mL of water into the above mixture and mix well to make a nanoemulsion; Add 22 g of poloxamer 407 to 50 mL of deionized water, and then add 0.10 g of sodium carboxymethylcellulose to make a gel solution; add the nanoemulsion to the gel solution, mix well, add water to 100 mL have to. The measured nanoemulsion in the above system is recorded as sample 2, and the specific parameters are shown in Table 1.
Embodiment 3
[0054] Weigh 4.00 g of eutectic product as the oil phase, add 5.00 g of polyoxyethylene castor oil and 5.00 g of polyethylene glycol 400 and mix well; gradually add 20 mL of water into the above mixture, and mix well to make a nanoemulsion; Add 0.4g of Carbomer 974 to 50 mL of deionized water, and then add 0.10 g of sodium carboxymethylcellulose; add the nanoemulsion to the gel solution, mix well, add water to 100 mL, and obtain. The measured nanoemulsion in the above system is recorded as sample 3, and the specific parameters are shown in Table 1.
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